Cholinergic–Monoaminergic Interactions in the Brain

Cholinergic–Monoaminergic Interactions in the Brain

1st Edition - January 1, 1978

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  • Editor: Larry Butcher
  • eBook ISBN: 9780323151344

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Cholinergic-Monoaminergic Interactions in the Brain investigates dynamic synaptic mechanisms in the brain and their links to various behaviors and related functional processes. More specifically, it explores neurochemical interactions by focusing on the relationship between cholinergic and monoaminergic mechanisms in the central nervous system. It also presents morphologic data to highlight the importance of structure in understanding function, particularly, that of the neostriatum and the role of acetylcholine and neurochemicals. Organized into six sections comprised of 18 chapters, this volume begins with an overview of various models of cholinergic-monoaminergic and other chemical interactions, based in part on interactive processes that are believed to operate in the peripheral nervous system. The next chapters focus on experimental observations on electrophysiologic and neurochemical interactions in the brain and the functional correlates of such interactions. The discussion then turns to the neurohistochemical and neurobiochemical aspects of cholinergic-monoaminergic interactions, the effects on neostriatal acetylcholine levels, and the synthesis of the cortico-neostriatal and thalamo-neostriatal pathways. The reader is also introduced to the effects of lesion in the globus pallidus, the electrophysiology of interactions, the effects of drugs thought to preferentially affect monoaminergic or related neurotransmission mechanisms on acetylcholine in the brain, and whether dopamine is excitatory or inhibitory upon neostriatal neurons. Finally, the book assesses the significance of central cholinergic-monoaminergic interactions for functional processes, both normal and pathologic. This book is a valuable resource for neuroscientists, pharmacologists, histochemists, behavioral biologists, psychobiologists, and psychologists.

Table of Contents

  • List of Contributors


    Part 1 Introduction

    Chemical Communication Processes Involving Neurons: Vocabulary and Syntax

    Part 2 Neurohistochemical and Neurobiochemical Aspects of Cholinergic-Monoaminergic Interactions

    Acetylcholinesterase in Rat Nigro-Neostriatal Neurons: Experimental Verification and Evidence for Cholinergic-Dopaminergic Interactions in the Substantia Nigra and Caudate-Putamen Complex

    Morphological Aspects of Dopaminergic-Cholinergic Neuronal Connections in the Rodent Striatum

    Acetylcholine Levels and Synthesis in the Neostriatum after Lesions in the Cerebral Cortex, Thalamus, and Globus Pallidus

    Part 3 Electrophysiologic Aspects of Interactions in the Brain

    Neurophysiologic Regulation of the Basal Ganglia

    Caudato-Thalamic Pathway Interactions

    Physiologic and Morphologic Characteristics of the Caudate Spiny Neuron

    Part 4 Neuropharmacology Aspects of Cholinergic-Monoaminergic Interactions

    Action of Dopamine in the Caudate Nucleus

    Nigro-Striatal Relations and the Mechanisms of Action of Amphetamine

    Studies of Cholinergic-Monoaminergic Interactions in Rat Brain

    The Transsynaptic Regulation of Acetylcholine Metabolism in Nuclei of Rat Brain: Pharmacologic Implications

    Effects of Dopaminergic and Serotonergic Agonists and Antagonists on Acetylcholine Levels and Synthesis in the Neostriatum

    Part 5 Behavioral and Related Functional Correlates of Cholinergic-Monoaminergic Interactions

    Cholinergic-Monoaminergic Interactions during Ontogenesis

    The Role of Central Monoamine and Acetylcholine Systems in Sleep-Wakefulness States: Mediation or Modulation?

    Neurotransmitter Regulation of Stress Responses: Relationship to Seizure induction

    The Substantia Nigra and Neostriatum: Substrates for Memory Consolidation

    Part 6 Clinical Correlates of Cholinergic-Monoaminergic Interactions

    Cholinergic-Monoaminergic Interactions Within the Striatum: Implications for Choreiform Disorders

    Observations Concerning Neurotransmitter Interaction in Schizophrenia


Product details

  • No. of pages: 416
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323151344

About the Editor

Larry Butcher

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