Chemistry, Biochemistry, and Pathology

1st Edition - January 1, 1958

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  • Editor: Robert P. Cook
  • eBook ISBN: 9781483271651

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Cholesterol: Chemistry, Biochemistry, and Pathology focuses on the properties, characteristics, compositions, and reactions of cholesterol. The selection first offers information on the history of cholesterol, including occurrence of cholesterol, early chemistry, related compounds, and analytical methods. The text then surveys the chemistry of cholesterol; methods of isolation and estimation of sterols; and distribution of sterols in organisms and in tissues. Discussions focus on quantitative determination of sterols, isolation procedures, distribution in animal tissues, sterols in plants, and sterol content of foodstuffs. The publication ponders on the physiology of the circulating cholesterol and lipoproteins and the biosynthesis of cholesterol. The manuscript then takes a look at the metabolism of cholesterol and other sterols in animal organisms; conversion of cholesterol to steroid hormones; microscopical localization of cholesterol in cells and tissues; and pathological manifestations of abnormal cholesterol metabolism. The selection is a valuable reference for readers interested in the properties and reactions of cholesterol.

Table of Contents

  • Preface

    List Of Contributors

    1. Historical Introduction

    I. The Discovery and Occurrence of Cholesterol

    II. Early Chemistry

    III. Related Compounds

    IV. Analytical Methods

    V. Metabolism


    2. Chemistry

    I. Introduction

    II. Nomenclature

    III. Table of Natural Sterols

    IV. Occurrence and Large-Scale Isolation of Cholesterol

    V. The Structure of Cholesterol

    VI. Reactions of Cholesterol

    VII. Physico-Chemical Measurements on Steroids

    VIII. Digitonide Formation

    IX. Color Reactions of Steroids

    X. Tables of Physical Constants of Cholesterol Derivatives


    3. Methods of Isolation and Estimation of Sterols

    I. Introduction

    II. Isolation Procedures

    III. Quantitative Determination of Sterols

    IV. Physical Methods

    V. Sterols in Parts of the Cell and in Plants

    VI. Summary and Conclusions


    4. Distribution of Sterols in Organisms and in Tissues

    I. Introduction

    II. Whole Organisms

    III. Distribution in Animal Tissues

    IV. Sterols in Plants

    V. The Sterol Content of Foodstuffs

    VI. Conclusions


    5. The Physiology of the Circulating Cholesterol and Lipoproteins

    I. The Distribution of Cholesterol between the Formed Elements of the Blood and the Blood Plasma

    II. The Physical State of the Plasma Cholesterol

    III. Species Differences

    IV. Race

    V. The Effect of Diet

    VI. Plasma Cholesterol in Man

    VII. Conclusions


    6. Biosynthesis of Cholesterol

    I. Introduction

    II. Pathways in Cholesterol Biosynthesis

    III. Sites of Sterol Biosynthesis in Animal Tissues

    IV. Sterol Biosynthesis in Yeast and Other Organisms

    V. The Labeling of Sterols


    7. The Metabolism of Cholesterol and Other Sterols in the Animal Organism

    I. Introduction

    II. Absorption of Sterols from the Intestine (R.P.C.)

    III. Esterification of Cholesterol (R.G.G.)

    IV. Cholesterol Metabolism in the Liver (R.G.G.)

    V. Metabolism of Cholesterol in Extrahepatic Tissues ( R.G.G.)

    VI. Factors Influencing Cholesterol Biosynthesis, Turnover, and Distribution in Tissues (R.G.G.)

    VII. The Excretory Pathways (R.P.C.)

    VIII. The Metabolism of Other Sterols (R.P.C.)

    IX. Summary


    8. Conversion of Cholesterol to Steroid Hormones

    I. Introduction

    II. Historical Reflections

    III. Corticoids

    IV. Androgens

    V. Estrogens

    VI. The Problem of Alternative Pathways Involved in Steroid Hormone Biosynthesis

    VII. Concluding Remarks


    9. Microscopical Localization of Cholesterol in Cells and Tissues

    I. Introduction

    II. Histological Demonstration of Cholesterol

    III. Distribution of Cholesterol in Cells, Organs and Tissues

    IV. Some Suggested Structural Functions of Cholesterol


    10. Pathological Manifestations of Abnormal Cholesterol Metabolism

    I. Introduction

    II. Normal Cholesterol Levels in Serum

    III. Hypercholesteremia

    IV. Hypocholesteremia

    V. Diseases Characterized by Cholesterol Deposition

    VI. Cholesterol and Cancer



    11. Treatment of Disorders of Cholesterol Metabolism

    I. Diet

    II. ß-Sitosterol

    III. Nicotinic Acid

    IV. Exercise

    V. Reduction of Abnormal Arterial Pressure Levels

    VI. Endocrine Therapy

    VII. Anti-biosynthetic Compounds

    VIII. Primary Hyperlipemias

    IX. Secondary Hyperlipemias


    12. Evolutionary Aspects of the Sterols

    I. Introduction

    II. Sterols of Animals

    III. Conclusions


    13. The Sterol Requirements of Insects and of Protozoa

    I. Insects

    II. Protozoa


    14. The Microbial Metabolism of Steroids

    I. Introduction

    II. Oxidation of Nuclear Positions in the Steroid Molecule

    III. Degradation of Steroids

    IV. Biosynthesis in Yeasts and Fungi


    15. Some Relations of Cholesterol to Other Lipids

    I. Introduction

    II. Interrelations with Other Lipids

    III. Results from Balance Experiments

    IV. The D Vitamins

    V. General Conclusions


    Appendix of Practical Methods

    I. General

    II. Extraction Procedures

    III. Colorimetric Determinations

    IV. Chromatography

    V. Estimation of Serum Lipoproteins by Zone Electrophoresis and Estimation of Cholesterol

    Author Index

    Subject Index

Product details

  • No. of pages: 554
  • Language: English
  • Copyright: © Academic Press 1958
  • Published: January 1, 1958
  • Imprint: Academic Press
  • eBook ISBN: 9781483271651

About the Editor

Robert P. Cook

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