Cholesterol Metabolism in Aging and Disease

Cholesterol Metabolism in Aging and Disease

1st Edition - November 1, 2022

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  • Author: Mark Mc Auley
  • Paperback ISBN: 9780128227923

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Cholesterol Metabolism in Aging and Disease provides in-depth coverage on the mechanistic intersection between the aging process and cholesterol metabolism. The book covers the discovery of cholesterol, its biochemistry, and how it came to have such a prominent role in aging and disease. Important areas such as cholesterol biosynthesis and cellular cholesterol homeostasis are described in detail. Technological advancements in computational modeling are also discussed to help improve our understanding of cholesterol metabolism so that new therapeutic avenues are opened to help treat age-related diseases associated with the dysregulation of this key system. This is a must have reference for students and researchers interested in, or working in, various aspects of aging. In addition, it is ideal for clinician researchers and gerontologists.

Key Features

  • Offers detailed, yet accessible descriptions of the biochemistry of cholesterol metabolism and the changes that take place as we age
  • Emphasizes the mechanistic changes to cholesterol metabolism which take place with age
  • Discusses the importance of cholesterol metabolism and how disruptions to it underpin age-related diseases


Graduate and PhD students as well as researchers interested or working in various aspects of aging, clinical researchers and medical professionals in biogerontology and geriatrics

Table of Contents

  • 1. Introduction
    2. The role of Cholesterol in the Body
    3. The Cholesterol Biosynthesis Pathway
    4. Maintaining intracellular Cholesterol Homeostasis
    5. The regulation of whole body Cholesterol Metabolism
    6. How does aging impact Cholesterol Metabolism?
    7. Cholesterol metabolism and Cardiovascular Disease
    8. Cholesterol Metabolism and Cancer
    9. Cholesterol Metabolism and Alzheimer’s Disease
    10. Cholesterol Metabolism in the Oldest old
    11. How Diet and Alcohol influences Cholesterol Metabolism
    12. Computational Models of Cholesterol metabolism

Product details

  • No. of pages: 240
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: November 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128227923

About the Author

Mark Mc Auley

Mark Mc Auley, PhD, is senior lecturer in chemical engineering at the University of Chester. He completed his PhD entitled “Systems Modelling of Human Ageing” under the tutelage of Professor Tom Kirkwood, CBE, an internationally acclaimed ageing researcher and Professor Darren Wilkinson an internationally renowned researcher in statistics. His teaching centers on applied biochemistry, biotechnology, molecular biology and bioinformatics. Mark has over 15 years’ experience of applying computing to challenges in bioscience. He uses computational modelling to help improve our understanding of complex biochemical pathways and research centers primarily on the ageing process. He has published over 30 peer-reviewed articles in the area of health, aging and nutrition.

Affiliations and Expertise

Senior Lecturer, University of Chester, UK

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