Chitosan in Drug Delivery

Chitosan in Drug Delivery

1st Edition - October 25, 2021

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  • Editors: Md Saquib Hasnain, Sarwar Beg, Amit Kumar Nayak
  • eBook ISBN: 9780128193372
  • Paperback ISBN: 9780128193365

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Description

Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery.

Key Features

  • Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications
  • Includes illustrations demonstrating the mechanism of biological interaction of chitosan
  • Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan

Readership

Postgraduate students, postdoctoral research fellows, academicians, pharmaceutical scientists including industrial pharmacists & analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development of natural polymer containing drug delivery

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • Preface
  • Chapter 1. Chitosan: source, chemistry, and properties
  • Abstract
  • 1.1 Introduction
  • 1.2 Sources of chitosan
  • 1.3 Chemistry of chitosan
  • 1.4 Properties of chitosan
  • 1.5 Conclusion
  • References
  • Chapter 2. Chitosan-based systems for oral drug delivery applications
  • Abstract
  • 2.1 Introduction
  • 2.2 Chitosan-based oral delivery systems
  • 2.3 Conclusion and future prospective
  • References
  • Chapter 3. Chitosan-based nanoparticles in drug delivery
  • Abstract
  • 3.1 Introduction
  • 3.2 Chitosan as drug delivery biopolymer
  • 3.3 Factors affecting the efficacy of chitosan-based nanoparticles
  • 3.4 Applications of chitosan-based nanoparticles for drug delivery
  • 3.5 Conclusions and future prospects
  • References
  • Chapter 4. Role of chitosan in transdermal drug delivery
  • Abstract
  • 4.1 Introduction
  • 4.2 Chitosan-based transdermal drug delivery systems
  • 4.3 Conclusion
  • References
  • Chapter 5. Chitosan in colon-targeted drug delivery
  • Abstract
  • 5.1 Introduction
  • 5.2 Mechanism of action of chitosan on colonic mucosa
  • 5.3 Chitosan as colon-specific drug carrier biopolymeric material
  • 5.4 Conclusion
  • References
  • Chapter 6. Chitosan as a biomaterial for implantable drug delivery
  • Abstract
  • 6.1 Introduction
  • 6.2 Implantable drug delivery system
  • 6.3 Nontypical implantable drug delivery system
  • 6.4 Chitosan: as a biomaterial
  • 6.5 Conclusion
  • Acknowledgment
  • Conflict of Interest
  • References
  • Chapter 7. Chitosan-based drug delivery systems in cancer therapeutics
  • Abstract
  • 7.1 Introduction
  • 7.2 Sources and isolation of chitosan
  • 7.3 Chemical structure and properties of chitosan
  • 7.4 Chitosan: as a polymer in anticancer treatment
  • 7.5 Different chemical derivatives of chitosan having anticancer activities
  • 7.6 Targeting of nanotherapeutics
  • 7.7 Conclusion
  • References
  • Chapter 8. In situ gelling systems of chitosan for potential drug delivery applications
  • Abstract
  • 8.1 Introduction
  • 8.2 Various chitosan-mediated in situ gel systems
  • 8.3 Conclusion and future scope
  • References
  • Chapter 9. Chitosan as mucoadhesive polymer in drug delivery
  • Abstract
  • 9.1 Introduction
  • 9.2 Mucoadhesion
  • 9.3 Chitosan as polymeric excipients
  • 9.4 Chitosan and its derivatives as mucoadhesive agents
  • 9.5 Conclusion
  • References
  • Chapter 10. Thiolated chitosan as an improved bioadhesive polymer in drug delivery
  • Abstract
  • 10.1 Introduction
  • 10.2 Synthesis of thiolated chitosan
  • 10.3 Thiolated chitosan derivatives
  • 10.4 Properties of thiolated chitosan
  • 10.5 Applications of thiolated chitosan
  • 10.6 Conclusion and future perspective
  • References
  • Chapter 11. Cross-linking of chitosan in drug delivery
  • Abstract
  • 11.1 Introduction
  • 11.2 General properties of chitosan
  • 11.3 The limitations of native chitosan as a carrier in drug delivery system
  • 11.4 Cross-linking of chitosan
  • 11.5 Conclusion
  • References
  • Chapter 12. Graft copolymers of chitosan in drug delivery applications
  • Abstract
  • 12.1 Introduction
  • 12.2 Chitosan: structure and chemistry
  • 12.3 Rational for graft copolymerizations of chitosan
  • 12.4 Various graft copolymers of chitosan in drug delivery
  • 12.5 Conclusions
  • References
  • Chapter 13. Carboxymethyl chitosan in advanced drug-delivery applications
  • Abstract
  • 13.1 Introduction
  • 13.2 Applications of carboxymethyl chitosan and its derivatives
  • 13.3 Conclusions and future prospects
  • References
  • Chapter 14. Chitosan-based hydrogels in drug delivery
  • Abstract
  • 14.1 Introduction
  • 14.2 Chitosan as biopolymer
  • 14.3 Preparation of chitosan-based hydrogels
  • 14.4 Drug delivery applications of chitosan hydrogels
  • 14.5 Conclusion
  • References
  • Chapter 15. Chitosan as a responsive biopolymer in drug delivery
  • Abstract
  • 15.1 Introduction
  • 15.2 Responsive polymers
  • 15.3 Chitosan
  • 15.4 Chitosan-based responsive carrier systems for drug delivery
  • 15.5 Conclusion
  • References
  • Chapter 16. Chitosan-based nanobiocomposites in drug delivery
  • Abstract
  • 16.1 Introduction
  • 16.2 Nanobiocomposites
  • 16.3 Chitosan
  • 16.4 Chitosan-based nanobiocomposites
  • 16.5 Conclusion
  • References
  • Chapter 17. Chitosan for delivery of biomolecules
  • Abstract
  • 17.1 Introduction
  • 17.2 Chitosan
  • 17.3 Biomolecules
  • 17.4 Biological activity of chitosan
  • 17.5 Functions of chitosan
  • 17.6 Delivery of proteins and peptides using chitosan system
  • 17.7 Delivery of vaccines using chitosan system
  • 17.8 Delivery of siRNA using chitosan system
  • 17.9 Delivery of growth factors using chitosan system
  • 17.10 Conclusion
  • Acknowledgment
  • Conflict of interest
  • References
  • Chapter 18. Novel chitosan-based strategies for insulin nanoencapsulation
  • Abstract
  • 18.1 Introduction
  • 18.2 Macromolecular self-assembly
  • 18.3 Nanoparticles design
  • 18.4 Encapsulation via nanospray drying
  • 18.5 Conclusion
  • Acknowledgment
  • References
  • Chapter 19. Chemically modified chitosan for biomolecule delivery
  • Abstract
  • 19.1 Conclusion
  • 19.2 Future perspective
  • Acknowledgments
  • References
  • Index

Product details

  • No. of pages: 556
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 25, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128193372
  • Paperback ISBN: 9780128193365

About the Editors

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and Expertise

Professor, Department of Pharmacy, Palamau Institute of Pharmacy, Jharkhand, India

Sarwar Beg

Sarwar Beg is Assistant Professor at Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Prior to joining Jamia Hamdard, Dr. Sarwar was worked with Jubilant Generics Limited, Noida, as Research Scientist and was responsible for QbD implementation in formulation and analytical development of generic products. He has over a decade of experience in the field of pharmaceutics, especially in the systematic development and characterization of novel and nanostructured drug delivery systems employing Quality by Design (QbD), Design of Experiments (DoE) and multivariate statistical approaches. Besides, Dr. Sarwar has good knowledge in applying various other advanced computational tools like drug release kinetic modeling, pharmacokinetic modeling and in vitro/in vivo correlation (IVIVC) approaches for efficient development of drug products. Dr. Beg has participated and presented his research work at several conferences in USA, Canada, China, India, Bangladesh, and has earned several “Best Paper” awards.

Affiliations and Expertise

Assistant Professor, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak is currently working as a Professor at Seemanta Institute of Pharmaceutical Sciences, Odisha, India. He earned his Ph.D. in Pharmaceutical Sciences from IFTM University, India. He worked as Senior Research Associate at IIT, Kanpur in a CSIR sponsored project. Dr. Nayak has over 13 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems made of natural biopolymers. He has authored over 130 research and review articles in various high impact peer-reviewed journals and 135 book chapters in various international books. In addition, he has authored 2 books and edited 17 books published by International publisher(s). He has received University Foundation Day Research Award-2019 by Biju Patnaik University of Technology, Odisha. He serves as a reviewer for several reputed journals and is a life member of Association of Pharmaceutical Teachers of India (APTI).

Affiliations and Expertise

Professor, Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Odisha, India

Ratings and Reviews

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  • Tabish M. Sun Oct 31 2021

    Chitosan in Drug Delivery

    Chitosan in Drug Delivery is an excellent book for drug delivery scientific researchers.