Chitosan in Biomedical Applications

Chitosan in Biomedical Applications

1st Edition - December 1, 2021

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  • Editors: Md Saquib Hasnain, Sarwar Beg, Amit Nayak
  • Paperback ISBN: 9780128210581
  • eBook ISBN: 9780128212448

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Description

Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of chitosan in biomedical applications and healthcare fields. Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of chitosan in biomedical applications. The book explores key topics, such as molecular weight, degree of deacetylation, and molecular geometry, along with an emphasis on recent advances in the field written by academic, industry, and clinical researchers. Chitosan in Biomedical Applications will be of interest to those in biomedical fields including the biomaterials and tissue engineering community investigating and developing biomaterials for biomedical applications, particularly graduate students, young faculty and others exploring chitosan-based materials.

Key Features

  • Provides methodology for the design, development and selection of chitosan in biomedical applications for particular therapeutic applications
  • Includes illustrations demonstrating the mechanism of biological interaction of chitosan
  • Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan

Readership

Postgraduate students, postdoctoral research fellows, biomedical scientists including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in biomedical sciences and process development of natural polymer for biomedical applications

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter 1. Chitosan: a versatile biopolymer
  • 1. Introduction
  • 2. Chitosan
  • 3. Biomedical application of chitosan
  • 4. Conclusion
  • Chapter 2. Antimicrobial uses of chitosan
  • 1. Introduction
  • 2. Chemistry of chitin and chitosan
  • 3. Chitosan and its derivatives as antibacterial agents
  • 4. Chitosan and its derivatives as antifungal agents
  • 5. Chitosan and its derivatives as antiviral agents
  • 6. Effects of degree of deacetylation and molecular weight on antimicrobial action of chitosan
  • 7. Conclusions
  • Chapter 3. Microscale and nanoscale chitosan-based particles for biomedical use
  • 1. Introduction
  • 2. Microscale biomedical approaches
  • 3. Nanoscale biomedical approaches
  • Chapter 4. Biomedical applications of electrospun chitosan nanofibers
  • 1. Introduction
  • 2. General properties of chitosan
  • 3. Extraction of chitosan
  • 4. Electrospun nanofibers: fundamental process, parameters, and challenges
  • 5. Biomedical applications of electrospun chitosan nanofibers
  • 6. Conclusion and future perspectives
  • Chapter 5. Chitosan nanocomposites for biomedical applications
  • 1. Introduction
  • 2. Chitosan
  • 3. Chitosan nanocomposites in drug delivery
  • 4. Chitosan nanocomposites in gene delivery
  • 5. Chitosan nanocomposites in tissue engineering
  • 6. Chitosan nanocomposites in wound healing
  • 7. Antimicrobial chitosan nanocomposites
  • 8. Chitosan nanocomposites in bioimaging
  • 9. Conclusion
  • Chapter 6. Uses of chitosan in drug delivery
  • 1. Introduction
  • 2. Chitosan extraction
  • 3. Properties of chitosan and its implications in drug delivery application
  • 4. Drug delivery applications
  • 5. Conclusion
  • Chapter 7. Tumor targeting strategies by chitosan-based nanocarriers
  • 1. Introduction
  • 2. Chitosan
  • 3. Factors affecting the efficacy of chitosan-based nanocarriers
  • 4. Anticancer drug delivery using chitosan-based nanocarriers
  • 5. Chitosan-based nanocarriers for passive targeting to tumors
  • 6. Chitosan-based nanocarriers for active targeting of tumors
  • 7. Chitosan-based stimuli-responsive nanocarrier systems for targeting
  • 8. Conclusion
  • Chapter 8. Environmental stimuli-sensitive chitosan nanocarriers in therapeutics
  • 1. Introduction
  • 2. Temperature-sensitive drug delivery system
  • 3. pH-sensitive drug delivery system
  • 4. Ultrasound-sensitive drug delivery system
  • 5. Redox-sensitive drug delivery system
  • 6. Photo-sensitive drug delivery system
  • 7. Magnetic field-sensitive drug delivery system
  • 8. Conclusion
  • Chapter 9. Protein and peptide delivery by chitosan systems
  • 1. Introduction
  • 2. Salient features of chitosan for delivery of protein and peptides
  • 3. N-Trimethyl chitosan
  • 4. Chitosan and its derivative-based carrier systems for protein and peptide delivery
  • 5. Conclusions and perspective
  • Conflict of interest
  • Chapter 10. Gene and growth factor delivery by chitosan systems
  • 1. Introduction
  • 2. Gene delivery
  • 3. Growth factor delivery
  • 4. Chitosan systems for growth factor delivery
  • Chapter 11. Mucosal vaccination through chitosan-based delivery systems
  • 1. Mucosal vaccination
  • 2. Chitosan as a smart polymer
  • 3. Conclusions
  • Chapter 12. Enzyme immobilization using chitosan systems
  • 1. Introduction
  • 2. Immobilization methods
  • 3. Chitosan configurations
  • 4. Horseradish peroxidase
  • 5. Glucose oxidase
  • 6. β-Galactosidase
  • 7. Conclusions
  • Abbreviations and Acronyms
  • Chapter 13. Applications of chitosan in orthopedics and dentistry
  • 1. Introduction
  • 2. Structure and properties of chitosan
  • 3. Human skeleton
  • 4. Orthopedics challenges and solutions
  • 5. Grafting
  • 6. Tissue engineering
  • 7. Three-dimensional bio-printing
  • 8. Orthopedic and dental applications of chitosan
  • 9. Conclusion
  • Chapter 14. Chitosan-based scaffolds in tissue engineering and regenerative medicine
  • 1. Introduction
  • 2. Chitosan
  • 3. Applications of chitosan-based scaffolds for bone regeneration
  • 4. Applications of chitosan-based scaffolds for cartilage regeneration
  • 5. Applications of chitosan-based scaffolds for dermal tissue regeneration
  • 6. Applications of chitosan-based scaffolds for nerve tissue regeneration
  • 7. Applications of chitosan-based scaffolds for vascular tissue regeneration
  • 8. Applications of chitosan-based scaffolds for corneal tissue regeneration
  • 9. Applications of chitosan-based scaffolds in regeneration of hepatic tissue
  • 10. Applications of chitosan-based scaffolds for cardiac tissue regeneration
  • 11. Conclusion
  • Chapter 15. Coating of chitosan onto bone implants
  • 1. Introduction
  • 2. Chitosan coating
  • 3. Factors affecting chitosan properties for use as bioactive coating
  • 4. Methods of chitosan coating on titanium for bone implants
  • 5. Other coatings based on chitosan
  • 6. Bioactivity of chitosan-coated titanium implants
  • 7. Future scopes and challenges
  • 8. Conclusions
  • Chapter 16. Bioimaging applications of chitosan-based systems
  • 1. Introduction
  • 2. Chitosan properties
  • 3. Application of chitosan in bioimaging techniques
  • 4. Conclusions
  • Index

Product details

  • No. of pages: 424
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: December 1, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128210581
  • eBook ISBN: 9780128212448

About the Editors

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and Expertise

Professor, Department of Pharmacy, Palamau Institute of Pharmacy, Jharkhand, India

Sarwar Beg

Sarwar Beg is Assistant Professor at Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Prior to joining Jamia Hamdard, Dr. Sarwar was worked with Jubilant Generics Limited, Noida, as Research Scientist and was responsible for QbD implementation in formulation and analytical development of generic products. He has over a decade of experience in the field of pharmaceutics, especially in the systematic development and characterization of novel and nanostructured drug delivery systems employing Quality by Design (QbD), Design of Experiments (DoE) and multivariate statistical approaches. Besides, Dr. Sarwar has good knowledge in applying various other advanced computational tools like drug release kinetic modeling, pharmacokinetic modeling and in vitro/in vivo correlation (IVIVC) approaches for efficient development of drug products. Dr. Beg has participated and presented his research work at several conferences in USA, Canada, China, India, Bangladesh, and has earned several “Best Paper” awards.

Affiliations and Expertise

Assistant Professor, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Amit Nayak

Dr. Amit Kumar Nayak is currently working as a Professor at Seemanta Institute of Pharmaceutical Sciences, Odisha, India. He earned his Ph.D. in Pharmaceutical Sciences from IFTM University, India. He worked as Senior Research Associate at IIT, Kanpur in a CSIR sponsored project. Dr. Nayak has over 13 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems made of natural biopolymers. He has authored over 130 research and review articles in various high impact peer-reviewed journals and 135 book chapters in various international books. In addition, he has authored 2 books and edited 17 books published by International publisher(s). He has received University Foundation Day Research Award-2019 by Biju Patnaik University of Technology, Odisha. He serves as a reviewer for several reputed journals and is a life member of Association of Pharmaceutical Teachers of India (APTI).

Affiliations and Expertise

Professor, Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Odisha, India

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