Chiral Analysis

Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained.

• Broad coverage - spectroscopic and separation methods covered in a single volume
• Up-to-date and detailed review of the various techniques available and/or under development in this field
• Contributions from leading experts in the field

Scientific professionals in the pharmaceutical industry, analytical chemists, technical libraries associated with the pharmaceutical industry, and university libraries

Part I Chapter 1. A History of Chirality (S. Mauskopf).

Chapter 2: Chiral Asymmetry in Nature (D. Kondepudi).
Chapter 3. Physical Properties and Enantiomeric Composition (Chong-Hui Gu, D.J.W. Grant).
Chapter 4. Emerging High-Throughput Screening Methods for Asymmetric Induction (M.G. Finn).

Part II Chapter 5. Analysis of Chiral Chromatographic Separations by Molecular Modeling (K.B. Lipkowitz).
Chapter 6. Gas chromatographic enantioseparation of chiral pollutants – Techniques and Results (W. Vetter, K. Bester).
Chapter 7. HPLC Resolution Using Polysaccharide Derivatives as CSPs (Chiyo Yamamoto, Yoshio Okamoto).
Chapter 8. Chiral Separations by Capillary Electrophoresis (A.M. Stalcup).
Chapter 9. Chiral Separations in Microfluidic Devices (D. Belder).

Part III Chapter 10. Instrumental Aspects of Chiroptical Detection (K.W. Busch et al.).
Chapter 11. Micro-Scale Polarimetry (D.J. Bornhop, S. Dotson).
Chapter 12. Chiral Analysis by Regression Modeling of Spectral Data (K.W. Busch, M.A. Busch).
Chapter 13. Electronic Circular Dichroism for Chiral Analysis (J. Gawronski, P. Skowronek).
Chapter 14. Determination of Molecular Stereochemistry using Optical Rotatory Dispersion, Vibrational Circular Dichroism and Vibrational Raman Optical Activity (P.L. Polavarapu).
Chapter 15. Vibrational Optical Activity in Chiral Analysis (L.A. Nafie, R.K. Dukor).
Chapter 16. Raman Optical Activity (E.W. Blanch et al.).
Chapter 17 Mass Spectral Methods of Chiral Analysis (B.L. Young et al.).
Chapter 18 Novel Chiral Derivatizing Agents Powerful for Enantioresolution and Determination of Absolute Stereochemistry by X-Ray Crystallographic and 1H NMR Anisotropy Methods (Nobuyuki Harada et al.).