Chemotherapy of Bacterial Infections

Chemotherapy of Bacterial Infections

1st Edition - January 1, 1964

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  • Editors: R. J. Schnitzer, Frank Hawking
  • eBook ISBN: 9781483273099

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Experimental Chemotherapy, Volume II: Chemotherapy of Bacterial Infections: Part I is devoted to the history, development, and progress of experimental chemotherapy of bacterial infections. The subject matter has been arranged according to particular groups of compounds, and in a few instances according to specific diseases. The emphasis of Volume II is placed on synthetic compounds. The literature is covered up to the latter part of 1963. It is hoped that this volume will be found useful by investigators and teachers concerned with experimental work on new substances and by physicians and veterinarians who use them. The book opens with a discussion of chemotherapy with antibacterial dyestuffs. This is followed by separate chapters on the mode of action of antibacterial substances such as sulfonamides, penicillins, and other antibiotics; the main lines on which research into antibacterial drugs has developed; and drug resistance for chemotherapy. Subsequent chapters deal with antibacterial chemotherapy with sulfonamides, the experimental pharmacology and toxicology of sulfonamides, the use of nitrofurans as chemotherapeutic agents, and antibacterial agents of limited action. The final chapters discuss experimental chemotherapy of tuberculosis and leprosy.

Table of Contents

  • Contributors


    Contents Of Volume I

    Contents Of Volume III

    Contents Of Volume IV

    1. Chemotherapy with Antibacterial Dyestuffs

    I. Early History of Antibacterial Chemotherapy

    II. Antibacterial Action of Acridine Dyestuffs

    III. Other Dyestuffs


    2. The Mode of Action of Some Antibacterial Substances

    I. Introduction

    II. Structure and Function in Bacterial and Mammalian Cells

    III. The Action of Sulfonamides

    IV. The Action of the Penicillins

    V. Other Antibiotics Which Affect Cell Wall Synthesis


    3. Strategy and Tactics in Antibacterial Chemotherapy

    I. Introduction: The Problem of Specificity

    II. The Different Levels of Chemotherapy

    III. Some Specific Examples of the Relation of Structure to Function in Antibacterial Drugs

    IV. Conclusions


    4. Microbial Resistance to Harsh and Destructive Environmental Conditions

    I. Introduction

    II. Historical Considerations: Trends in Research on Resistance to Therapeutically Useful and Useless Substances and Conditions

    III. Heat-Resistant and Thermophilic Bacteria

    IV. Organisms Growing in High Sugar and Salt Concentrations

    V. Radiation Resistance

    VI. Resistance to Acid and Alkaline Conditions

    VII. Resistance to Heavy Metals

    VIII. Resistance to Certain Enzyme Inhibitors

    IX. Resistance to Surf ace-Active Agents and Lytic Enzymes

    X. Resistance to Certain Other Disinfectants and Preservatives

    XI. Some Special Cases

    XII. Concluding Remarks


    5. Antibacterial Chemotherapy with Sulfonamides

    Part 1: Historical Survey

    I. Introduction

    II. Development of Sulfonamides

    Part 2: Sulfonamide Action In Vitro

    I. Methods

    II. Bacteristatic Effect of Newer Sulfonamides

    III. Discussion of the In Vitro Tests with Sulfonamides

    Part 3: Sulfonamide Action In Vivo

    I. Experimental Procedures

    II. Results of in Vivo Experiments

    III. Correlation of in Vitro and in Vivo Experiments

    IV. Concluding Remarks


    6. Experimental Pharmacology and Toxicology of Sulfonamides

    I. Introduction

    II. Pharmacology

    III. Synergists, Potentiators, and Antagonists Including Combinations with Other Drugs

    IV. Toxicology


    7. The Nitrofurans—Chemotherapeutic Properties

    I. Introduction

    II. Synthesis

    III. Properties of the Nitrofurans

    IV. Summary


    8. Antibacterial Agents of Limited Action

    I. Introduction

    II. Compounds with Predominantly Local Activity

    III. Compounds with Systemic Activity


    9. Experimental Chemotherapy of Tuberculosis and Other Mycobacterial Infections

    I. Introduction

    II. Basic Biologic Principles

    III. Techniques for Detection and Measurement of Chemotherapeutic Activity

    IV. Chemotherapeutic Effect of Active Compounds

    V. Other Mycobacterial Infections

    VI. Conclusion


    10. Experimental Chemotherapy of Leprosy

    I. Human Leprosy (Hansen's Disease)

    II. Mycobacterium Leprae (Hansen's Bacillus)

    III. Murine Leprosy

    IV. Screening Procedures with Mycobacterium Lepraemurium

    V. Chemotherapeutic Activity of Antileprosy Agents


    Author Index

    Subject Index

Product details

  • No. of pages: 632
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483273099

About the Editors

R. J. Schnitzer

Frank Hawking

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