Chemokine Receptors - 1st Edition - ISBN: 9780121821890, 9780080884004

Chemokine Receptors, Volume 288

1st Edition

Serial Volume Editors: Richard Horuk
Editor-in-Chiefs: John Abelson Melvin Simon
eBook ISBN: 9780080884004
Hardcover ISBN: 9780121821890
Imprint: Academic Press
Published Date: 6th October 1997
Page Count: 426


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Table of Contents

Chemokine Receptors:

A. Richmond, S. Mueller, J.R. White, and W. Schraw, C-X-C Chemokine Receptor Desensitization Mediated through Ligand-Enhanced Receptor Phosphorylation on Serine Residues.

A. Chuntharapai and K.J. Kim, Generation of Monoclonal Antibodies to Chemokine Receptors.

M. Halks-Miller, J. Hesselgesser, I.J. Miko, and R. Horuk, Chemokine Receptors in Developing Human Brain.

Z-X. Wang, Y-H. Cen, H-H. Guo, J-G. Du, and S.C. Peiper, Expression of Chemokine Receptors in Insect Cells Using Baculovirus Vectors.

S.C. Peiper, Z-H.i Lu, T-Y. Zhang, and Z-X. Wang, Chimeric Chemokine Receptors for Analysis of Structure-Function Relationships.

F.S. Monteclaro, H. Arai, and I.F. Charo, Molecular Approaches to Identifying Ligand Binding and Signaling Domains of C-C Chemokine Receptors.

S. Pitchford, M. Hirst, H.G. Wada, S.D.H. Chan, V.E. Timmermans, and G.M.K. Humphries, Characterization of Functional Activity of Chemokine Receptors Using Cytosensor Microphysiometer. .

P.M. Murphy, Calcium Flux Assay of Chemokine Receptor Expression in Xenopus Oocytes.

J.Rucker, B.J. Doranz, A.L. Edinger, D. Long, J.F. Berson, and R.W. Doms, Cell-Cell Fusion Assay to Study Role of Chemokine Receptors in Human Immunodeficiency Virus Type 1 Entry.

G.L. Bennett and R. Horuk, Iodination of Chemokines for Use in Receptor Binding Analysis.

V. Fingar, H-H. Guo, Z-H. Lu, and S.C. Peiper, Expression of Chemokine Receptors by Endothelial Cells: Detection by Intravital Microscopy Using Chemokine-Coated Fluorescent Microspheres.

Chemokine in Disease:

V.C. Broaddus and C.A. Hebert, Neutralization of Interleukin-8 in in Vivo Models of Lung and Pleural Injury.

A.R. Glabinski, M. Tani, V.K. Tuohy, and R.M. Ransohoff, Murine Experimental Autoimmune Encephalomyelitis: A Model of Immune-Mediated Inflammation and Multiple Sclerosis.

D.A Arenberg, P.J. Polverini, S.L. Kunkel, A. Shanafelt, and R. Strieter, In Vitro and in Vivo Systems to Assess Role of C-X-C Chemokines in Regulation of Angiogenesis.

T.J. Standiford, S.L. Kunkel, and R.M. Strieter, Role of Chemokines in Antibacterial Host Defense.

D.A. Griffiths-Johnson, P.D. Collins, P.J. Jose, and T.J. Williams, Animal Models of Asthma: Role of Chemokines.

J.M. Schrider, Identification and Structural Characterization of Chemokines in Lesional Skin Material of Patients with Inflammatory Skin Disease.

Signal Transduction and Chemokines:

S.R. McColl and P. Naccache, Calcium Mobilization Assays.

S.K. Beckner, G-Protein Activation by Chemokines.

R. Horuk, Adenylate Cyclase Assays to Measure Chemokine Receptor Function.

K.B. Bacon, Analysis of Signal Transduction Following Lymphocyte Activation by Chemokines.

K.B. Bacon, Calcium Mobilization and Phosphoinositide Turnover as Measure of Chemokine Receptor Function in Lymphocytes. Author Index. Subject Index.


Chemokines are major mediators of immune cells and are involved in a wide range of proinflammatory human diseases, including rheumatoid arthritis, multiple sclerosis, and organ transplant rejection. It has recently been discovered that their receptors are involved in HIV infection. The characterization of these molecules and their receptors is thus of primary importance in understanding a number of human diseases and infections. This volume and its companion Volume 287 Chemokines provide comprehensive experimental protocols used in this field of research.

Key Features

@introbul:Key Features @bul:* Chemokine receptors

  • Chemokines in disease
  • Signal transduction of chemokines


Biochemists, molecular biologists, immunologists, cell biologists, pharmacologists, and biomedical researchers.


No. of pages:
© Academic Press 1997
Academic Press
eBook ISBN:
Hardcover ISBN:


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About the Serial Volume Editors

Richard Horuk Serial Volume Editor

Affiliations and Expertise

Berlex Biosciences, Richmond, California, U.S.A.

About the Editor-in-Chiefs

John Abelson Editor-in-Chief

Affiliations and Expertise

California Institute of Technology, Division of Biology, Pasadena, U.S.A.

Melvin Simon Editor-in-Chief

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA