Chemistry for Toxicity Testing - 1st Edition - ISBN: 9780250405473, 9781483191829

Chemistry for Toxicity Testing

1st Edition

Editors: C.W. Jameson Douglas B. Walters
eBook ISBN: 9781483191829
Imprint: Butterworth-Heinemann
Published Date: 28th August 1984
Page Count: 246
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Description

Chemistry for Toxicity Testing presents the chemical requirements for external toxicity studies. This book is organized into four parts encompassing 18 chapters that discuss the basic chemistry considerations for toxicity testing program. It also describes the structure-activity prediction of the carcinogenicity of chemicals and the development of methods for mixing chemicals in rodent feed. Some of the topics covered in the book are the formulations of insoluble and immiscible test agents in liquid medium for toxicity testing; problems of testing commercial-grade chemicals; analysis of dosed feed samples; determination of chemical and vehicle mixtures stability; and the toxicity of inhaled chemicals. Other parts explore the methods for generation of test atmosphere and the monitoring of vapor concentration in test atmosphere. An evaluation of dosage analysis data from a problem-solving point of view is provided. The discussion then shifts to the effects of good laboratory practices on chemistry requirements for toxicity testing. The final part is devoted to the monitoring of aerosol chemicals inhalation in chambers.
The book can provide useful information to chemists, toxicologists, students, and researchers.

Table of Contents


Contents

The Editors

The Contributors

Preface

I. General Chemistry Considerations

1. Analytical Chemistry Requirements for Toxicity Testing of Environmental Chemicals

3. Problems of Testing Commercial-Grade Chemicals

4. Chemical/ Vehicle Mixing and Analysis Problems at a Bioassay Laboratory

II. Dosage Mixing and Analysis

5. Methods Development for Mixing Chemicals in Rodent Feed

6. Formulations of Insoluble and Immiscible Test Agents in Liquid Vehicles for Toxicity Testing

7. Analysis of Dosed Feed Samples

8. Stability Determinations for Chemical/ Vehicle Mixtures

III. Chemical Inhalation Studies

9. Inhalation Toxicology: An Overview

10. Methods for Generation of Test Atmospheres

11. Monitoring Vapor Concentrations in Test Atmospheres

12. Chemical Monitoring of Aerosols in Inhalation Chambers

13. Detection of Degradation Products in Inhalation Test Atmospheres and Analysis in Combustion Products Toxicology

14. Analytical Monitoring for Both Intentional and Unintentional

Test Chemical Release during the Conduct of Inhalation Toxicity Studies

IV. Chemistry Data Evaluation

15. Data Evaluation and Management

16. Evaluation of Dosage Analysis Data from a Problem-Solving Point of View

17. Management of a Repository for Chemicals Used in Coded Toxicity Testing

18. Effects of Good Laboratory Practices on Chemistry Requirements for Toxicity Testing

Index

Details

No. of pages:
246
Language:
English
Copyright:
© Butterworth-Heinemann 1984
Published:
Imprint:
Butterworth-Heinemann
eBook ISBN:
9781483191829

About the Editor

C.W. Jameson

Douglas B. Walters