Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs

Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs

The Peptides Analysis, Synthesis, Biology, Vol. 8

1st Edition - January 6, 1987

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  • Editors: Sidney Udenfriend, Johannes Meienhofer, Clark W. Smith
  • eBook ISBN: 9781483218014

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Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The book discusses the anatomy, physiology, and clinical disorders of the neurohypophysis; the biosynthesis of neurohypophyseal peptides; and the structure-activity relationships of neurohypophyseal peptides, with an emphasis on the role of conformational features. The text also describes conformational studies of neurohypophyseal hormones by physical chemical techniques; the central nervous system effects of neurohypophyseal peptides; and the effects of neurohypophyseal hormones on the kidney. The effects of neurohypophyseal hormones on the cardiovascular systems are also considered. Chemists, neurobiologists, and people involved in the study of neurohypophyseal hormones will find the book invaluable.

Table of Contents

  • Preface IX

    Chapter 1 Clinical Disorders of the Neurohypophysis

    I Anatomy

    II Synaptic Input

    III Physiology

    IV Pathophysiologic Mechanisms

    V Hypofunction of the Neurohypophysis: Diabetes Insipidus

    VI Hyperfunction of the Posterior Pituitary—Syndrome of Inappropriate Secretion of Antidiuretic Hormone


    Chapter 2 The Other Neurohypophyseal Peptides

    I Introduction

    II Opioid Peptides

    III Hypothalamic Releasing and Release-Inhibiting Factors

    IV Gastrointestinal Peptides

    V Other Peptides

    VI Physiological Significance of Other Neurohypophyseal Peptides


    Chapter 3 Biochemistry and Biology of Vasopressin, Oxytocin, and Their Corresponding Neurophysins

    I Introduction

    II Structural Aspects—Polyproteins

    III Vasopressin and Oxytocin—Functional Aspects

    IV Gene Structure

    V Comparison of the Bovine and Rat Genes

    VI Transcriptional Control

    VII Precursor Structure

    VIII Processing and Modifications

    IX Genetic Defect—Diabetes Insipidus

    X Expression in Peripheral Tissues

    XI Perspectives


    Chapter 4 Structure-Activity Relationships of Neurohypophyseal Peptides

    I. Introduction

    II. Naturally Occurring Neurohypophyseal Hormones—An Overview

    III. Structure-Activity Relationships of Oxytocin Agonists

    IV. Structure-Activity Relationships of Antagonist Analogs of the Neurohypophyseal Hormones That Competitively Block the Actions of the Native Hormone at Receptors for Oxytocin

    V. Structure-Activity Relationships of Vasopressin Agonists

    VI. Antagonist Analogs of the Neurohypophyseal Hormones That Competitively Block the Action(s) of the Native Hormones at Receptors for Vasopressin

    VII. Concluding Remarks


    Chapter 5 The Conformation of Neurohypophyseal Hormones

    I Introduction

    II Theories Relating Conformation to Activity

    III Conformational Assignments

    IV Energy-Based Molecular Modelling

    V Summary and Conclusions

    Chapter 6 Central Nervous System Effects of Neurohypophyseal Peptides

    I Introduction

    II Animal Studies

    III Human Studies—Neurohypophyseal Peptides and Memory

    IV Neurohypophyseal Peptides and Drug Tolerance and Dependence

    V Effects of Oxytocin in the CNS

    VI CNS Effects of Neurohypophyseal Peptides Not Related to Learning or Memory

    VII Possible Sites and Mechanisms of Action of Neurohypophyseal Peptides in the CNS

    VIII Conclusions


    Chapter 7 Renal Effects and Hormonal Interaction with the Neurohypophyseal Hormone, Vasopressin

    I Introduction

    II Nephron Sites of AVP Action

    III Cellular Action of Hydroosmotic Action of AVP

    IV Modulating Factors of AVP Action

    V Interactions of Other Hormones and AVP

    VI Role of AVP in Pathophysiological States

    VII Effect of AVP on Chloride and Other Electrolyte Transport

    VIII Effect of AVP on Renal Hemodynamics

    IX Effect of AVP on Renin Secretion

    X Other Renal Effects and Metabolism

    XI AVP Antagonists


    Chapter 8 Cardiovascular Effects of Neurotiypophyseal Peptides

    I Effects on Cells

    II Local Effects on Regional Vascular Tissues

    III Integrated Hemodynamic Effects

    IV Effects of Vasopressin on Neural Control of Circulation

    V Agonists and Antagonists Used to Study Cardiovascular Effects

    VI Summary



Product details

  • No. of pages: 382
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: January 6, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9781483218014

About the Editors

Sidney Udenfriend

Johannes Meienhofer

Clark W. Smith

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