Description

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area.

Key Features

* Comprehensively reviews all aspects of heparin and heparan sulfate research * Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work * Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Readership

Chemists, biochemists, medical doctors, researchers, students and practitioners

Table of Contents

1. Structure and Active Domains of Heparin (B. Casu).
2. Structure and Function of Cell Associated and Pericellular Heparan Sulfate Proteoglycans (S.G. Velleman and C. Liu).
3. Methods for Structural Analysis of Heparin and Heparan Sulfate (I. Capila et al.).
4. Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate (C. Noti, P.H. Seeberger).
5. Biochemical and Pharmacological Rationale for Synthetic Heparin Polysaccharides (J.M. Walenga et al.).
6. Seperation and Sequencing of Heparin and Heparan Sulfate Saccharides (M.A. Skidmore, J.E. Turnbull).
7. Biosynthesis of Heparin and Heparan Sulfate (Shuji Mizumoto et al.).
8. Remodeling of Heparan Sulfate by Extracellular Endosulfatases (Xinbin Ai et al.).
9. Heparan Sulfate Degradation by Heparanases (K.J. Bame).
10. Lysosomal Degradation of Heparin and Heparan Sulfate (P.J. Meikle et al.).
11. Heparin Regulation of the Complement System (Haining Yu et al.).
12. Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins (T. Rudd et al.).
13. Heparin Activation of Serpins (J.A. Huntington).
14. Role of Heparin in Fibroblast Signalling (N.J. Harmer).
15. Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction (A.I. de Agostini

Details

No. of pages:
792
Language:
English
Copyright:
© 2005
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080529059
Print ISBN:
9780080448596
Print ISBN:
9780444559395

About the editors

Hari Garg

Affiliations and Expertise

Faculty of Medicine, Harvard Medical School, Boston, MA, USA

Robert Linhardt

Affiliations and Expertise

Rensselaer Polytechnic Institute, Troy, New York, USA

Charles Hales

Affiliations and Expertise

Pulmonary and Critical Care unit, Harvard Medical School Massachusetts General Hospital, Boston, USA

Reviews

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area.