Chemistry and Biological Activities of Bacterial Surface Amphiphiles

Chemistry and Biological Activities of Bacterial Surface Amphiphiles

1st Edition - January 1, 1981

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  • Editor: Gerald Shockman
  • eBook ISBN: 9780323151986

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Chemistry and Biological Activities of Bacterial Surface Amphiphiles is a collection of papers presented at a workshop entitled Chemistry and Biological Activities of Bacterial Surface Amphiphiles, held in New Orleans, Louisiana, January 12, 1981. The goals of the workshop were to review the state of knowledge of bacterial amphiphiles; to consider and possibly standardize approaches to testing for biological activities of amphiphiles; to set guidelines for criteria of purity of amphiphile preparations used in biological testing; to determine major future avenues in amphiphile research; and to foster future cooperative research in the field. The book is organized into eight parts. Part I contains papers on the chemical composition and biological properties of bacterial amphiphiles. Part II presents studies on the extraction and purification of amphiphiles. The papers in Part III focus on the detection and quantitation of bacterial amphiphiles. Part IV presents studies on the physical properties of bacterial amphiphiles. The contributions in Parts V and VI deal with the biosynthesis of amphiphiles and the role of amphiphiles in the producing organisms, respectively. Part VII examines interactions of bacterial amphiphiles with mammalian systems. Part VIII presents the final plenary session to the workshop, which reviewed areas of discussion that followed the formal presentations.

Table of Contents

  • Contributors


    1. Introduction to the Chemical and Biological Properties of Bacterial Amphiphiles

    Chemical Composition and Properties of Amphiphiles

    Extraction and Purification of Amphiphiles

    Cellular Localization, Excretion, and Physiological Roles of Lipoteichoic Acid in Gram-Positive Bacteria

    Chemistry and Biology of Lipopolysaccharides and Lipid A

    2. Extraction and Purification of Amphiphiles

    A Model System for the Purification of Amphiphiles: The Preparation of Lipoteichoic Acid Using Liposomes

    Hydrophobic Interaction Chromatography: A Method for Purification of Streptococcus mutans BHT Lipoteichoic Acid

    Heterogeneity of Lipoteichoic Acid of Streptococcus sanguis

    Aggregation of Staphylococcal Lipoteichoic Acid

    Criteria of Purity

    3. Detection and Quantification of Bacterial Amphiphiles

    Serological Methods

    Quantitative Immunoelectrophoresis Techniques in Studies of Identification, Purification, and Distribution of Membrane Lipomannan

    Fatty Acid Esters of Streptococcal Cell Wall Polysaccharides as Amphiphiles

    4. Physical Properties of Bacterial Amphiphiles

    Physical Principles and Modes of Interaction of Membrane Lipids and Amphiphiles

    Determination of Molecular Structure of Amphiphiles Using NMR Spectroscopy

    5. Biosynthesis of Amphiphiles

    Synthesis of Teichoic Acids

    Biosynthesis of D-Alanyl-Lipoteichoic Acid in Lactobacillus casei

    Biosynthesis of the Membrane Lipoteichoic Acid of Streptococcus faecium (S. faecalis ATCC 9790)

    Alanine Ester Substitution and Its Effect on the Biological Properties of Lipoteichoic Acids

    On the Participation of Lipoteichoic Acid in the Biosynthesis of Wall Teichoic Acids

    Glycerophosphoglycolipids Presumptive Biosynthetic Precursors of Lipoteichoic Acids

    6. Role of Amphiphiles in the Producing Organisms

    Effect of Growth Conditions on Lipoteichoic Acid Production

    Release of Lipoteichoic Acid by Group A Streptococci

    Depletion of Lipoteichoic Acid from Intact Cells of Streptococcus faecium

    Cellular LTA Content during Growth and Division in Streptococcus faecium (ATCC 9790)

    Lipoteichoic Acid Content and Tolerance of Staphylococci to Cell Wall Antibiotics

    Streptolysin S Carrier Activity of Lipoteichoic Acid

    7. Interaction of Bacterial Amphiphiles with Mammalian Systems

    Inflammatory Properties of an Oral Bacterial Lipopolysaccharide and Human Dental Plaque

    Interaction of Amphiphiles with Macrophages and Eucaryotic Enzyme Systems

    Complement Activation by a Streptococcal LTA

    The Interaction of Lipoteichoic Acid with Streptococcal Proteins, Serum Albumin, and Animal Cell Membranes

    Induction of Murine Lymphocytes and Macrophages by Components of Bacterial Cell Walls and Membranes

    In Vitro Studies of Adhesion of Streptococcus sanguis to Salivary Pellicles

    The Role of Lipoteichoic Acid in the Adherence and Colonization of Oral Streptococci

    Possible Role of Lipoteichoic Acids in the Pathogenicity of Dental Plaque

    8. Plenary Discussion


Product details

  • No. of pages: 404
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 1, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323151986

About the Editor

Gerald Shockman

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