Chemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions.

Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail.

Alpha-Aminophosphonic acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanephosphonates are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonates are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA

Key Features

* provides ideas for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds) * reviews structure, spectra and biological activity of H-phosphonates and their derivatives * examines new areas of application of phosphorus-containing compounds


For Professors, researchers, students and practitioners working in the fields of organophosphorus Chemistry, Organic Chemistry, Polymer Chemistry, Pharmacy, Production of polymers with reduced flammability, Production of agrochemicals, Medicinal Chemistry

Table of Contents

Chapter 1. Methods for preparation and physical properties of H-phosphonates 1.1. From phosphorus trichloride and alcohols
1.2. From H-phosphonic acid
1.3. From white phosphorus and alcohols
1.4. Others
1.5. Physical properties
1.6. Thermal stability

Chapter 2. Structure and spectral characteristics of H-phosphonates 2.1. Electronic structure of phosphorus atom
2.2. Nature of the chemical bonds in phosphoryl group
2.3. Molecular structure of dimethyl H-phosphonate
2.4. Tautomerization of dialkyl H-phosphonates
2.5. Spectral characteristics

Chapter 3. Reactivity of H-phosphonates 3.1. Acidity of H-phosphonate diesters
3.2. Disproportionation
3.3. Reduction
3.4. Hydrolysis
3.5. Acidolysis
3.6. Substitution reactions at the phosphorus atom

Chapter 4. Important classes of compounds 4.1. Aminophosphonic acids
4.2. Bisphosphonates
4.3. Nucleoside H-phosphonates
4.4. Epoxyalkylphosphonates
4.5. Poly(alkylene H-phosphonate)s
4.6. Metal salts of dialkyl H-phosphonates
4.7. Complexes of dialkyl H-phosphonates

Chapter 5. Application of H–phosphonates and their derivatives 5.1. Physiologically-active substances
5.2. Polymer additives
5.3. Degrading and alkylating agents of polymers
5.4. Heat, light and UV stabilizers
5.5. Catalysts
5.6. Corr


No. of pages:
© 2006
Elsevier Science
Print ISBN:
Electronic ISBN:

About the author

Kolio D. Troev

Affiliations and Expertise

Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria