Foreword
Preface
1. Introduction
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2. Nature of Genetic Material
I. Genes and DNA
II. Chemical Composition and Structure
III. Replication and Gene Expression
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3. Mode of Action and Types of Mutations Induced by Chemicals
I. Substitution by Base Analogs
II. Chemical Alterations of DNA and Its Constituent Nucleotides
III. Compounds That Physically Bind to DNA
IV. Depolymerization of DNA
V. Somatic Mutations and Carcinogenesis
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4. Repair of Genetic Damage
I. Variation among Species
II. Types of Reparable Damage and Mechanism of Repair
III. Methods for Studying Repair in Mammalian Cells
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5. Test System for the Detection and Scoring of Mutants
I. DNA Transformation
II. Bacteriophage
III. Bacterial Test Systems
IV. Ascomycete
V. Drosophila
VI. Cytological Examination of Chromosomes
VII. Mammalian Test Systems
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6. Tabular Summaries of Chemical Mutagens
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7. Alkylating Agents I (Aziridines, Mustards, Nitrosamines, and Related Derivatives)
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8. Alkylating Agents II (Epoxides, Aldehydes, Lactones, AIkyI Sulfates, Alkane Sulfonic Esters, and Related Derivatives)
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9. Drugs, Food Additives, Pesticides, and Miscellaneous Mutagens
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