Chemical Glycobiology

Chemical Glycobiology

Synthesis, Manipulation and Applications of Glycans

1st Edition - September 18, 2017

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  • Editor: Barbara Imperiali
  • Hardcover ISBN: 9780128114698
  • eBook ISBN: 9780128114704

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Description

Chemical Glycobiology, Volume 597, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume, the first on chemical glycobiology, contains comprehensive chapters on the Discovery of New Glycosidases from Metagenomic Libraries, Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme, A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases, Directed evolution of glycopeptides using mRNA display, Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars, and Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates. Readers will find the latest information on this developing area of research, as reported by leaders in the field.

Key Features

  • Presents an updated volume in this regular series
  • Covers research on chemical glycobiology

Readership

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of Contents

  • 1. Discovery of New Glycosidases from Metagenomic Libraries
    Stephen George Withers, Zach Armstrong and Peter Rahfeld
    2. Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme
    David Kwan
    3. A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases
    Matt DeLisa
    4. Directed evolution of glycopeptides using mRNA display
    Isaac Krauss
    5. Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars
    Barbara Imperiali and Cristina Zamora
    6. Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates
    Michel Gilbert, Ian Schoenhofen and Martin Young
    7. Syntheses of fluorescent gangliosides for the studies of raft domains
    Makoto Kiso
    8. Profiling of Sugar Nucleotides
    Rob Field
    9. Chemoenzymatic glycan remodeling of natural and recombinant glycoproteins
    Lai-Xi Wang
    10. Glycoengineered Outer Membrane Vesicles as a platform for vaccine development
    Mario Feldman
    11. Identification and Design of Synthetic B Cell Epitopes for Carbohydrate-based Vaccines
    Peter Seeberger and Felix Broecker
    12. Strategies in the Design and Use of Synthetic ‘Internal Glycan’ Vaccines
    Ben Davis
    13. Evaluation of Virus Like Particle Based Tumor-Associated Carbohydrate Immunogen in a Mouse Tumor Model
    Xuefei Huang, Xuanjun Wu and Suttipun Sungsuwan

Product details

  • No. of pages: 430
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: September 18, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128114698
  • eBook ISBN: 9780128114704

About the Serial Volume Editor

Barbara Imperiali

Barbara Imperiali is Professor of Biology and Chemistry at MIT, USA

Affiliations and Expertise

MIT, Cambridge, MA, USA

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