Chemical Approaches to Brain Function

1st Edition - January 1, 1973
Editor: S Ehrenpreis
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 8 2 0 - 6

Neurosciences Research, Volume 5: Chemical Approaches to Brain Function is an eight-chapter text that discusses the advances in the techniques used to examine the development,… Read more

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Neurosciences Research, Volume 5: Chemical Approaches to Brain Function is an eight-chapter text that discusses the advances in the techniques used to examine the development, control, and function of neurotransmitters in the central nervous system. The opening chapter deals with the use of organ culture to investigate the processes of axonal growth of adrenergic neurons, the control of synthesis of norepinephrine, and its release on new axonal sprouts. These topics are followed by a presentation of the development of adrenergic neurons in the central nervous system. The next three chapters consider the function of central adrenergic neurons; the use of 6-hydroxydopamine and catecholamine fluorescence; and the effects of L-dopa on protein synthesis. The discussion then shifts to the catecholamines in the central nervous system to aggressive behavior and the amino acids as neurotransmitters. The concluding chapter focuses on the cholinergic transmission in describing some neurophysiological and neurochemical correlates of behavior. Neuroscientists and neuroresearchers will find this book invaluable.

List of Contributors

Preface

Contents of Previous Volumes

Sympathetic Ganglia in Organ Culture

I. Introduction

II. Development of the Peripheral Nervous System and the Role of Nerve Growth Factor ( NGF )

III. Organ Culture of Adult Sympathetic Ganglia

IV. Regulation of Enzyme Levels in Sympathetic Ganglia

V. Conclusion

References

The Development of Catecholaminergic Neurons of the Central Nervous System

I. Introduction

II. Histogenesis of the Catecholaminergic Neurons

III. Endogenous Dopamine and Norepinephrine

IV. Enzymes Involved in the Biosynthesis and Inactivation of Catecholamines

V. Uptake and Storage Mechanisms for Catecholamines

VI. Functional Aspects of Developing Catecholaminergic Neurons

VII. Summary

References

Studies on the Function of Central Noradrenergic Neurons

I. Introduction

II. Localizing Norepinephrine-Containing Central Synapses

III. Effects of Norepinephrine on Central Neurons

IV. Actions of Norepinephrine on Defined Postsynaptic Neurons

V. The Noradrenergic Synaptic Projection to Cerebellar Purkinje Cells

VI. Discharge Patterns of Norepinephrine-Containing Neurons in Unrestrained, Unanesthetized Cats

VII. Conclusions

References

Selective Lesions of Central Catecholamine Pathways: Application in Functional Studies

I. Introduction

II. Materials and Methods

III. Principal Organization of the Monoamine Pathways

IV. Selective Lesions of the Monoamine Pathways on the Basis of Their Anatomy

V. Stereotaxic Lesions with 6-Hydroxydopamine

VI. Interpretation of Lesion Studies

VII. Functional Studies on the Nigrostriatal DA System after 6-Hydroxydopamine Lesions

VIII. Conclusions

References

Effects of Inhibitors and Stimulators of Protein Synthesis on the Cerebral Actions of L-Dopa

I. Introduction

II. Materials and Methods

III. Observations

IV. Summary

References

The Catecholamines and Aggressive Behavior

I. Introduction

II. The Peripheral Nervous System, Catecholamines, and Aggression

III. The Central Nervous System, Catecholamines, and Aggression

IV. Clinical Associations

V. Conclusions

References

Amino Acids as Central Nervous Transmitters: Biochemical Studies

I. Introduction

II. Uptake Studies

III. Unique Synaptosomes Storing Certain Amino Acids

IV. New Directions

References

Interdisciplinary Approach to the Study of Behavior in Related Mice Types

I. Introduction

II. Evolution, Behavior, and Neurotransmitters in Different Strains and Species of Mice

III. The Effects of Drastic Changes in Afferent Input on Behavior and Neurochemistry in Mice

IV. The Effects of Environmental Stress on Behavior and Neurotransmitters in Mice

V. Drug Effects on Behavior and Mouse Brain Chemistry

VI. Speculations and Conclusions

References

Author Index

Subject Index