Chemical Approaches to Brain Function - 1st Edition - ISBN: 9780125125055, 9780323158206

Chemical Approaches to Brain Function

1st Edition

Editors: S Ehrenpreis
eBook ISBN: 9780323158206
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 276
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Neurosciences Research, Volume 5: Chemical Approaches to Brain Function is an eight-chapter text that discusses the advances in the techniques used to examine the development, control, and function of neurotransmitters in the central nervous system.
The opening chapter deals with the use of organ culture to investigate the processes of axonal growth of adrenergic neurons, the control of synthesis of norepinephrine, and its release on new axonal sprouts. These topics are followed by a presentation of the development of adrenergic neurons in the central nervous system. The next three chapters consider the function of central adrenergic neurons; the use of 6-hydroxydopamine and catecholamine fluorescence; and the effects of L-dopa on protein synthesis. The discussion then shifts to the catecholamines in the central nervous system to aggressive behavior and the amino acids as neurotransmitters. The concluding chapter focuses on the cholinergic transmission in describing some neurophysiological and neurochemical correlates of behavior. Neuroscientists and neuroresearchers will find this book invaluable.

Table of Contents

List of Contributors


Contents of Previous Volumes

Sympathetic Ganglia in Organ Culture

I. Introduction

II. Development of the Peripheral Nervous System and the Role of Nerve Growth Factor ( NGF )

III. Organ Culture of Adult Sympathetic Ganglia

IV. Regulation of Enzyme Levels in Sympathetic Ganglia

V. Conclusion


The Development of Catecholaminergic Neurons of the Central Nervous System

I. Introduction

II. Histogenesis of the Catecholaminergic Neurons

III. Endogenous Dopamine and Norepinephrine

IV. Enzymes Involved in the Biosynthesis and Inactivation of Catecholamines

V. Uptake and Storage Mechanisms for Catecholamines

VI. Functional Aspects of Developing Catecholaminergic Neurons

VII. Summary


Studies on the Function of Central Noradrenergic Neurons

I. Introduction

II. Localizing Norepinephrine-Containing Central Synapses

III. Effects of Norepinephrine on Central Neurons

IV. Actions of Norepinephrine on Defined Postsynaptic Neurons

V. The Noradrenergic Synaptic Projection to Cerebellar Purkinje Cells

VI. Discharge Patterns of Norepinephrine-Containing Neurons in Unrestrained, Unanesthetized Cats

VII. Conclusions


Selective Lesions of Central Catecholamine Pathways: Application in Functional Studies

I. Introduction

II. Materials and Methods

III. Principal Organization of the Monoamine Pathways

IV. Selective Lesions of the Monoamine Pathways on the Basis of Their Anatomy

V. Stereotaxic Lesions with 6-Hydroxydopamine

VI. Interpretation of Lesion Studies

VII. Functional Studies on the Nigrostriatal DA System after 6-Hydroxydopamine Lesions

VIII. Conclusions


Effects of Inhibitors and Stimulators of Protein Synthesis on the Cerebral Actions of L-Dopa

I. Introduction

II. Materials and Methods

III. Observations

IV. Summary


The Catecholamines and Aggressive Behavior

I. Introduction

II. The Peripheral Nervous System, Catecholamines, and Aggression

III. The Central Nervous System, Catecholamines, and Aggression

IV. Clinical Associations

V. Conclusions


Amino Acids as Central Nervous Transmitters: Biochemical Studies

I. Introduction

II. Uptake Studies

III. Unique Synaptosomes Storing Certain Amino Acids

IV. New Directions


Interdisciplinary Approach to the Study of Behavior in Related Mice Types

I. Introduction

II. Evolution, Behavior, and Neurotransmitters in Different Strains and Species of Mice

III. The Effects of Drastic Changes in Afferent Input on Behavior and Neurochemistry in Mice

IV. The Effects of Environmental Stress on Behavior and Neurotransmitters in Mice

V. Drug Effects on Behavior and Mouse Brain Chemistry

VI. Speculations and Conclusions


Author Index

Subject Index


No. of pages:
© Academic Press 1973
Academic Press
eBook ISBN:

About the Editor

S Ehrenpreis

Ratings and Reviews