
Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B
Description
Key Features
- Helps readers understand the wide array of topics surrounding anesthesia
- Includes sections on Pharmacophore QSAR, QM, ONIOM, and the kinetic modeling of electrophysiology data
- Broaches genetics, model organisms and general genetic strategies
Readership
Computational chemists, synthetic and medicinal chemists, biophysicists, physiologists, neuroscientists at all levels, neurologists, psychiatrists and, of course, anesthesiologists
Table of Contents
Computational approaches
1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics
Grace Brannigan
2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics
Vincenzo Carnevale
3. Anesthetic parameterization
Jerome Henin
4. Pharmacophore QSAR, QM, ONIOM
Edward Bertaccini
5. Kinetic modeling of electrophysiology data
Robert CantorGenetics and model organisms
6. General genetic strategies
Philip G. Morgan
7. Worms
Margaret Sedensky
8. Flies
Bruno van Swinderen
9. Tadpoles
Kellie Ann Woll
10. Zebrafish
Victoria Bedell and Julia Dallman
11. Mice
Max KelzPhotolabeling
12. Mass spect ID of adducts
Kellie Ann Woll
13. Photolabeling protection/competition
Jonathan CohenXenon
14. Xenon-protein interactions
Benjamin Roose and Ivan Dmochowski
15. Xenon gas delivery/recovery procedures
Mervyn Maze
16. Hyperpolarized Xe-129 MRI
Mitchell Albert
17. CT imaging
Andrew McKinstry-WuElectrophysiology
18. Native system electrophysiology (slices, cells, in vivo)
Boris Heifets
19. Voltage-gated ion channels (Kv, Nav)
Manuel Covarrubias
20. Ligand-gated ion channels
Stuart A. Forman
21. Other channels (HCN/K2P/TRP)
Paul M. Riegelhaupt and Peter A. GoldsteinStructural Approaches
22. Soluble proteins
Patrick J. Loll
23. Membrane proteins
Yan Xu and Pei Tang
24. NMR
Yan Xu and Pei Tang
25. Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels
John Kent BlasieEvolving Biophysical Technologies
26. Fluorescent Anesthetics
Daniel Emerson and Ivan Dmochowski
27. Investigation of anesthetic-protein interactions by a thermodynamic approach
Renyu Liu
28. Tissue/organism EPR
luca turin
29. Lipids, Membranes and Pressure reversal
Sarah VeatchIn vivo technologies; established and evolving
30. Optoanesthesia
Andrew McKinstry-Wu
31. Optogenetics, Chemogenetics
Kenneth Solt
32. Genetic reporters of neruonal activity: c-fos, genetically encoded calcium indicators
Andrew Hudson
33. Genomics and Proteomic Techniques
Jonathan Pan
34. Neurochemistry of Anesthetic States
Ralph Lydic
35. Electroencephalography
Alexander Proekt
36. PET
Harry Scheinin
37. Drug discovery and development
Douglas Raines
38. The use of glutamatergic anesthetics (ketamine, nitrous oxide and xenon) in depression
Peter Nagele
39. Brain Imaging Using Hyperpolarized 129Xe MRI
Francis Hane
Product details
- No. of pages: 336
- Language: English
- Copyright: © Academic Press 2018
- Published: April 16, 2018
- Imprint: Academic Press
- eBook ISBN: 9780128145753
- Hardcover ISBN: 9780128145746
About the Serial Volume Editors
Roderic Eckenhoff
Affiliations and Expertise
Ivan Dmochowski
Affiliations and Expertise
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