Chemical and Biochemical Applications

Chemical and Biochemical Applications

1st Edition - December 1, 1983

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  • Editor: Pierre Laszlo
  • eBook ISBN: 9780323156349

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NMR of Newly Accessible Nuclei, Volume 1: Chemical and Biochemical Applications is a 10-chapter text that explores the properties, advantages, developments, and chemical and biochemical applications of NMR technique. This book describes first the operation of an NMR spectrometer under its two aspects, namely, the instrumental and the computational aspects. The next chapters are devoted to some of the most important pulse sequences. The discussion then shifts to the various factors determining the position of the observed absorption and those responsible for the various relaxation processes. The last chapters deal with the specific applications of NMR, including in cation salvation, calcium-binding proteins, polyelectrolyte systems, halogens, and antibiotic ionophores. This book is of value to inorganic and analytical chemists, and biophysicists.

Table of Contents

  • Contributors

    General Preface

    Preface to Volume 1

    Contents of Volume 2

    A. General Features

    1. Multinuclear Instrumentation and Observation

    I. Introduction

    II. The Multinuclear NMR Spectrometer

    III. Multinuclear Observation


    2. Techniques That Can Enhance Sensitivity, Improve Resolution, Correlate NMR Spectral Parameters, and Lead to Structural Information

    I. Introduction

    II. Sensitivity Enhancement Techniques

    III. The Nuclear Overhauser Effect

    IV. Sensitivity Enhancement via Population Transfer

    V. How to Determine the Number of Protons Directly Coupled to Heteronucleus

    VI. How to Determine the Chemical Shifts of the Protons Directly Coupled to a Heteronucleus

    VII. How to Determine Whether a Heteronucleus Is Directly Coupled to a Like Heteronucleus

    VIII. How to Determine Whether Two Nuclei Belong to the Same Coupling Network

    IX. Resolution Enhancement Techniques

    X. Concluding Remarks


    3. Computational Considerations

    I. Data Acquisition

    II. Basic Data Reduction

    III. Extended Features of FT NMR Processing

    IV. Special Problems of Broad Line Spectra

    V. Current Trends in NMR Computation


    4. Factors Contributing to the Observed Chemical Shifts of Heavy Nuclei

    I. Introduction

    II. Intramolecular Factors

    III. Intermolecular Factors


    5. Quadrupolar and Other Types of Relaxation

    I. Introduction

    II. Relaxation in the Region of Motional Narrowing

    III. The Rotational Correlation of Time

    IV. Relaxation Interactions Modulated by Molecular Rotation

    V. Relaxation of Quadrupolar Nuclei

    VI. The Future


    B. Selected Features

    6. Cation Solvation

    I. Introduction

    II. Chemical Shift Measurements

    III. Nuclear Magnetic Relaxation


    7. Calcium-Binding Proteins

    I. Introduction

    II. An Overview of Calcium-Binding Proteins

    III. Structure of the Calcium-Binding Site

    IV. Nuclear Magnetic Resonance Studies of Calcium-Binding Proteins

    V. Future Studies


    8. Amphiphilic and Polyelectrolyte Systems

    I. Polyelectrolytes: Polycharged Macromolecules and Aggregates of Ionic Amphiphiles

    II. Counterion Binding: Methods and Theories

    III. Counterion Binding: Quadrupole Splittings

    IV. Counterion Binding: Quadrupole Relaxation

    V. Quadrupole Relaxation Studies on Counterion Binding to Polyelectrolytes

    VI. Quadrupole Relaxation and Chemical Shift Studies on Counterion Binding in Amphiphilic Systems

    VII. Quadrupole Splitting Studies on Counterion Binding in Amphiphilic Systems

    VIII. Hydration in Colloidal Systems: General Aspects and NMR Methods

    IX. Deuteron NMR for Phase Diagram Determination in Surfactant Systems

    X. 2H- and 17O-NMR Quadrupole Splittings and Hydration in Amphiphilic Mesophases

    XI. 17O-NMR Relaxation and the Hydration of Surfactant Micelles and Polyelectrolytes


    9. Chlorine, Bromine, and Iodine

    I. Introduction

    II. Halide Ions in Aqueous and Nonaqueous Solutions

    III. The ClO4- Ion

    IV. Surfactant Systems

    V. Macromolecular Systems

    VI. Covalently Bonded Halogens

    VII. Conclusions


    10. Antibiotic Ionophores

    I. Introduction

    II. Solution Conformation

    III. Nuclear Magnetic Resonance Studies of Ion-Ionophore Interactions in Solution

    IV. Nuclear Magnetic Resonance Studies in Membranal Systems



Product details

  • No. of pages: 316
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: December 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323156349

About the Editor

Pierre Laszlo

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