Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system.
Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS).
- Presents all the current findings on the potential for chelation as a therapy for metal intoxication
- Presents practical guidelines for selecting the most appropriate chelating agent
- Includes coverage on radionuclide exposure and metal storage diseases
- Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
Professional toxicologists, pharmacologists, medical chemists, chemists and clinicians
List of Abbreviations
1. General chemistry of metals and chelating agents
2. Chelating agents as therapeutic compounds
3. Diagnosis and evaluation of metal poisonings
4. Chelation Treatment during acute and chronic Metal Poisonings
5. Decorpoation of Radionuclides
6. Therapy of metal storage diseases (genetic diseases)
7. Guidance and precautions for clinicians
8. Concluding remarks
- No. of pages:
- © Academic Press 2016
- 15th April 2016
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Jan Aaseth was born in 1943 in Norway. He graduated in medicine in 1968 from University of Oslo. After the internship period he became authorized physician in 1970. In the period 1970-77 he worked at department of clinical chemistry and Institute of clinical biochemistry, Oslo University Hospital, with a grant from the National Research Council. He completed his doctoral thesis on metal chelation in 1976, and became an authorized specialist in medical biochemistry. In the period 1977-83 he continued his research on biochemical toxicology at the National Institute of Occupation Health of Norway. During this time he specialized in occupational medicine, and he chaired the Department of Experimental Toxicology for two years. After a subsequent period of specialization also in internal medicine, he was appointed as chair and professor of the Department of Occupational Medicine, University of Tromsø, Norway. Later, he has been head of department of clinical chemistry and section on endocrinology at Innlandet Hospital, and in recent years professor at Hedmark University College.
Professor Aaseth is an enthusiastic teacher. During his carrier he has lectured on medical biochemistry, toxicology, occupational and environmental medicine, internal medicine, nutrition and endocrinology, and he has been supervisor to numerous undergraduate, graduate and postgraduate students during their research projects. He has published some 200 papers.
Professor Aaseth is chair of the Nordic Trace Element Society and vice chair of the Committee for Geomedicine of The Norwegian Academy of Science. He has served on the organizing or scientific committees of several international conferences, including as chair of the First International Symposium on ‘Trace Elements in Human Health and Disease’ in Loen, Norway, 1985, and also of the subsequent Nordic symposia on this topic in 1993 and in 2013. He served in the scientific committee of the International Conference on Chelation, Paphos, Cyprus 2012, and in the organizing committee of the Conference of the International Society of Trace Element Research in Humans, Dubrovnik, October 2015.
Professor, Deptatment of Public Health, Hedmark University College, Elverum, Hedmark, Norway; Kongsvinger Hospital, Innlandet, Hedmark, Norway
Guido Crisponi is full professor of Analytical Chemistry om tjeDepartment of Chemical and Geological Sciences at University of Cagliari, Monserrato in Cagliari, Italy. Born in 1945, he took his degree in Chemistry in 1968 at the University of Cagliari. Since this date, he has worked uninterruptedly at University of Cagliari. Previously, Professor Crisponi has served in the following capacities:
- President of "Società Chimica Italiana - Sezione Sardegna" (2000-2001)
- Dean of the Department of "Scienze Chimiche" at Cagliari University (2004-2007)
- President of the European Group of Thermodynamic of Metal Complexes (2010-2013)
- Chair of two ISMEC meetings in Cagliari (1997 and 2007), and of two International Summer Schools, the first on Inorganic Biochemistry (2013) and the second on Bioinorganic Medicinal Chemistry (2015)
- Guest Editor of four issues of Coordination Chemistry Reviews published (1999, 2008, 2012 and 2015), and of two issues of Current Medicinal Chemistry, the first on “The State of Art in the Treatment of Metal Toxicity” (2014) and the second on “Applications of Bioinorganic Chemistry in Medicinal Chemistry”, to be published
- Author of the chapter “Metal Ion Toxicity” on Encyclopedia of Inorganic and Bioinorganic Chemistry (John Wiley & Sons, Ltd)
- Coauthor of seven books
- Author of more than 120 papers on international Journals
The majority of Professor Crisponi works deal with analytical studies on the distribution of toxic elements in various human tissues, solution equilibria studies on the interaction between metal ions and bio-molecules by potentiometric, spectrophotometric and NMR techniques, and design, synthesis and characterization of metal chelators for clinical applications to remove toxic metal ions from humans. He is member of the Editorial Board of Mini-Reviews in Medicinal Chemistry, Journal of Inorganic Chemistry and Journal of Analytical Methods in Chemistry.
Professor, Department of Chemical and Geological Sciences, University of Cagliari, Monserrato - Cagliari, Italy
Ole Andersen is a Professor Emeritus in the Department of Science, Systems and Models at Roskilde University in Denmark, and is also a member of the International Commission on Occupational Health; executive secretary for the Scientific Committee on the Toxicology of Metals; titular member of the steering committee for the Division of Chemistry and Human Health; a member of the Subcommittee on Toxicology and Risk Assessment, International Union of Pure and Applied Chemistry; a member of the task group on terminology in ecotoxicology, International Union of Pure and Applied Chemistry; secretary for the International Society for Trace Element Research in Humans; the chairman of the external review committee at Hahn Meitner Research Institute, Berlin, Germany in the program on environment and health, expert consultant on chelation treatment of metal intoxication for International Program on Chemical Safety, consultant to the Ontario Ministry of Labor on health effects of nickel, member of the Advisory Coordination Council for the Danish Ministry of Health's Center for Environmental Health Research, founding chairman for the Academy of the Technical Sciences’ Environmental Risk Council, referee for the Ontario Ministry of Labor on document on health effects of cadmium, referee for various national research councils. Editor, guest editor and referee for numerous peer review journals. Chairman or secretary for organizing committees for several international conferences. Dr. Andersen is the author of more than 200 peer reviewed publications.
Professor, Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
"It surpasses its goal of showcasing the recent developments in the use of chelating agents for metal overexposure and metal storage diseases…This is a valuable addition to the field of metal toxicity and a handy resource for clinicians to gain an understanding of metal toxicity, diagnosis, and treatment. Score: 95 - 4 Stars" --Doody's, Chelation Therapy in the Treatment of Metal Intoxication