Description

Biomaterials and medical devices must be rigorously tested in the laboratory before they can be implanted. Testing requires the right analytical techniques. Characterization of biomaterials reviews the latest methods for analyzing the structure, properties and behaviour of biomaterials.

Beginning with an introduction to microscopy techniques for analyzing the phase nature and morphology of biomaterials, Characterization of biomaterials goes on to discuss scattering techniques for structural analysis, quantitative assays for measuring cell adhesion, motility and differentiation, and the evaluation of cell infiltration and tissue formation using bioreactors. Further topics considered include studying molecular-scale protein-surface interactions in biomaterials, analysis of the cellular genome and abnormalities, and the use of microarrays to measure cellular changes induced by biomaterials. Finally, the book concludes by outlining standards and methods for assessing the safety and biocompatibility of biomaterials.

With its distinguished editors and international team of expert contributors, Characterization of biomaterials is an authoritative reference tool for all those involved in the development, production and application of biomaterials.

Key Features

  • Reviews the latest methods for analyzing the structure, properties and behaviour of biomaterials
  • Discusses scattering techniques for structural analysis, quantitative assays for measuring cell adhesion, and motility and differentiation
  • Examines the evaluation of cell infiltration and tissue formation using bioreactors

Readership

Industrial and academic researchers in the biomedical sector

Table of Contents

Contributor contact details

Woodhead Publishing Series in Textiles

Chapter 1: Microscopy techniques for analyzing the phase nature and morphology of biomaterials

Abstract:

1 Introduction: basic imaging concepts

1.2 Image perception and interpretation

1.3 Light microscopy

1.4 Laser scanning confocal microscopy (LSCM)

1.5 Scanning electron microscopy (SEM)

1.6 Atomic force microscopy (AFM)

Chapter 2: Scattering techniques for structural analysis of biomaterials

Abstract:

2.1 Introduction

2.2 Light scattering

2.3 Wide-angle X-ray diffraction

2.4 Measuring orientation using X-ray diffraction

2.5 Small-angle scattering techniques

2.6 Small-angle X-ray scattering (SAXS)

2.7 Small-angle neutron scattering (SANS)

2.8 Acknowledgment

Chapter 3: Quantitative assays for measuring cell adhesion and motility in biomaterials

Abstract:

3.1 Introduction

3.2 Cell attachment assays

3.3 Cell adhesion strength

3.4 Collective motility of cell populations

3.5 Individual cell motility

3.6 Conclusion and future trends

Chapter 4: Assays for determining cell differentiation in biomaterials

Abstract:

4.1 Introduction

4.2 Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) assays

4.3 Protein and chemical assays

4.4 Imaging assays

4.5 Future trends

Chapter 5: Bioreactors for evaluating cell infiltration and tissue formation in biomaterials

Abstract:

5.1 Introduction

5.2 Bioreactor designs

5.3 Evaluation of cell infiltration and cell seeding

5.4 Evaluation of tissue formation

5.5 Importance of computational fluid mechanics in modeling, imaging, and simulation of the bioreactors

5.6 Failure of bioreactors

5.7 Future trends

5.8 Conclusion

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Details

No. of pages:
334
Language:
English
Copyright:
© 2013
Published:
Imprint:
Woodhead Publishing
Print ISBN:
9781845698102
Electronic ISBN:
9780857093684

About the editors

M Jaffe

Professor Michael Jaffe was with Celanese and Hoechst Celanese Research in the USA before leaving for the Biomedical Engineering Department at New Jersey Institute of Technology.

Affiliations and Expertise

New Jersey Institute of Technology, USA

W. Hammond

Willis B. Hammond is a Research Professor in the Department of Biomedical Engineering at NJIT.

Affiliations and Expertise

Major and Chief MLSO, Royal Army Medical College, Millbank, London, UK

P Tolias

Peter Tolias is Director of the Bio-innovation Program and a Research Professor in the Schaefer School of Engineering and Science at the Stevens Institute of Technology, USA.

Affiliations and Expertise

University of Medicine and Dentistry New Jersey

T Arinzeh

Treena Arinzeh is Professor of Biomedical Engineering at NJIT.

Affiliations and Expertise

New Jersey Institute of Technology, USA

Reviews

"...a collection of topics fundamental for the characterization of biomaterials, contributed by the experts in the respective fields...very well-written and useful overview, suitable for specialists as well as researchers new to the field."--Biomat.net, March 2013

A brief, yet very well-written and useful overview, suitable for specialists as well as researchers new to the field., Dr. Aleksandr Ovsianikov, The Biomaterials Network.