Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research.

Key Features

Covers reviews of methodology and research in all aspects of protein chemistry.
Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of Contents

  • Preface
  • Chapter One Next Generation Sequencing Methodologies - An Overview
    • 1 Introduction/NGS
    • 2 Sample Submission Strategies
    • 3 Phenotyping Challenges and Strategies
    • 4 Development of NGS Technologies
    • 5 Application of NGS
    • 6 Bioinformatics
  • Chapter Two Next Generation Sequencing in the Clinical Domain: Clinical Advantages, Practical, and Ethical Challenges
    • 1 Introduction
    • 2 What is NGS?
    • 3 Explosion of Exome Sequencing Papers
    • 4 The Successes of Exome Sequencing
    • 5 The Successes of Genome Sequencing
    • 6 Ethics of WES
    • 7 NGS in Routine Clinical Practice?
  • Chapter Three Opportunities and Challenges for Genome Sequencing in the Clinic
    • 1 Introduction
    • 2 Milestones in the Development of Genetic Mapping
    • 3 Strategies for the Application of Next-Generation Sequencing in Genetic Mapping
    • 4 Consequence of Gene Discovery in Research Programs
    • 5 Challenges Around Incorporating Sequencing to the Clinic
  • Chapter Four Polymorphisms in Neuropsychiatric and Neuroinflammatory Disorders and the Role of Next Generation Sequencing in Early Diagnosis and Treatment
    • 1 Polymorphisms in Major Depressive Disorders
    • 2 Polymorphisms in ADHD
    • 3 Polymorphisms in Neuroinflammatory Diseases
    • 4 Multiple Sclerosis
    • 5 Alzheimer’s Disease
    • 6 Parkinson’s Disease
    • 7 Role of the NGS in Early Diagnostic and Treatment
    • 8 Conclusions
  • Chapter Five Structural Modelling Pipelines in Next Generation Sequencing Projects
    • 1 Introduction
    • 2 Protein Structure and Function
    • 3 Structural Modeling Methods
    • 4 Assessing Functional Impact of nsSNPs
    • 5 Protein–Protein Interaction Networks
  • Author Index
  • Subject Inde

Details

No. of pages:
208
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123942876
Electronic ISBN:
9780123982735

Reviews

"The authority, originality, and editing of the reviews are first class." -- NATURE