Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research
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Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research

1st Edition - October 4, 2012

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  • Editor: Mark I. Rees
  • eBook ISBN: 9780123982735

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Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research.

Key Features

  • Covers reviews of methodology and research in all aspects of protein chemistry
  • Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of Contents

    • Preface
    • Chapter One Next Generation Sequencing Methodologies - An Overview
      • 1 Introduction/NGS
      • 2 Sample Submission Strategies
      • 3 Phenotyping Challenges and Strategies
      • 4 Development of NGS Technologies
      • 5 Application of NGS
      • 6 Bioinformatics
    • Chapter Two Next Generation Sequencing in the Clinical Domain: Clinical Advantages, Practical, and Ethical Challenges
      • 1 Introduction
      • 2 What is NGS?
      • 3 Explosion of Exome Sequencing Papers
      • 4 The Successes of Exome Sequencing
      • 5 The Successes of Genome Sequencing
      • 6 Ethics of WES
      • 7 NGS in Routine Clinical Practice?
    • Chapter Three Opportunities and Challenges for Genome Sequencing in the Clinic
      • 1 Introduction
      • 2 Milestones in the Development of Genetic Mapping
      • 3 Strategies for the Application of Next-Generation Sequencing in Genetic Mapping
      • 4 Consequence of Gene Discovery in Research Programs
      • 5 Challenges Around Incorporating Sequencing to the Clinic
    • Chapter Four Polymorphisms in Neuropsychiatric and Neuroinflammatory Disorders and the Role of Next Generation Sequencing in Early Diagnosis and Treatment
      • 1 Polymorphisms in Major Depressive Disorders
      • 2 Polymorphisms in ADHD
      • 3 Polymorphisms in Neuroinflammatory Diseases
      • 4 Multiple Sclerosis
      • 5 Alzheimer’s Disease
      • 6 Parkinson’s Disease
      • 7 Role of the NGS in Early Diagnostic and Treatment
      • 8 Conclusions
    • Chapter Five Structural Modelling Pipelines in Next Generation Sequencing Projects
      • 1 Introduction
      • 2 Protein Structure and Function
      • 3 Structural Modeling Methods
      • 4 Assessing Functional Impact of nsSNPs
      • 5 Protein–Protein Interaction Networks
    • Author Index
    • Subject Index

Product details

  • No. of pages: 208
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: October 4, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123982735

About the Serial Volume Editor

Mark I. Rees

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