Chagas Disease, Volume 75

1st Edition

Part A

Print ISBN: 9780123858634
eBook ISBN: 9780123858641
Imprint: Academic Press
Published Date: 18th August 2011
Page Count: 390
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This thematic volume provides authoritative, up-to-date reviews addressing recent advances as well as an overview for the research and clinical communities on the endemic infection of Chagas disease. Lead researchers discuss epidemiology and control measures as well as various diagnosis techniques, treatments, and therapies currently being used. The text includes a history of Chagas disease and an outlook for the next century.


Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Researchers in parasitology, tropical medicine and entomology.

Table of Contents

Series Editors



Epidemiology of American Trypanosomiasis (Chagas Disease)

1.1. Historical Background

1.2. Mechanisms of Transmission of Trypanosoma cruzi

1.3. Epizootiology of Trypanosoma cruzi

1.4. Epidemiology of Human Trypanosoma cruzi Infection in the Endemic Countries

1.5. Epidemiology of Trypanosoma cruzi Infection in the United States

1.6. Trypanosoma cruzi Infection in Non-Endemic Countries Other than the United States

1.7. Perspectives on the Control of Chagas Disease

Acute and Congenital Chagas Disease

2.1. Introduction

2.2. Acute Phase

2.3. Clinical and Diagnostic Aspects of Congenital Trypanosoma cruzi Infection

2.4. Antitrypanosomal Drug Treatment

2.5. Epidemiology of Congenital Chagas Disease

2.6. Approaches to the Control of Congenital Chagas Disease

2.7. Conclusions

Cell-Based Therapy in Chagas Disease

3.1. Introduction

3.2. Cell Therapy in Cardiac Diseases

3.3. Cell Therapy in Chagas Disease

3.4. Clinical Trials

3.5. Future Perspectives for Cell-Based Therapies in Chagas Disease

Targeting Trypanosoma cruzi Sterol 14α-Demethylase (CYP51)

4.1. Introduction

4.2. Sterol Biosynthesis

4.3. Potential Drug Targets in the Pathway

4.4. Trypanosoma cruzi Sterol 14α-Demethylase (CYP51)

4.5. Inhibitors of Trypanosoma cruzi CYP51

4.6. Structural Basis for CYP51 Druggability

4.7. Anti-Parasitic Effects of CYP51 Inhibition in Trypanosoma cruzi


Experimental Chemotherapy and Approaches to Drug Discovery for Trypanosoma cruzi Infection

5.1. Introduction

5.2. Compound Selection

5.3. In Vitro Efficacy Testing

5.4. Toxicity Testing

5.5. In Vivo Efficacy Testing

5.6. Testing for Drug-Like Propertie


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© Academic Press 2011
Academic Press
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"One is struck by the quality and scholarship of the various chapters and the obviously efficient editing."
"The policy of the editors of Advances in Parasitology to include reviews from any aspect of parasitology and the high standard of individual papers have resulted in this series of volumes becoming an indispensable source for students, teachers, and research workers."