Cerebrospinal Fluid and Subarachnoid Space

Cerebrospinal Fluid and Subarachnoid Space

Volume 1: Clinical Anatomy and Physiology

1st Edition - August 19, 2022

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  • Editors: R. Shane Tubbs, Joe Iwanaga, Elias Rizk, Aaron Dumont, Anthony D'Antoni
  • Hardcover ISBN: 9780128195093

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Cerebrospinal Fluid and Subarachnoid  Space: Volume 1: Clinical Anatomy and Physiology is the first book devoted to the comprehensive clinical anatomy of the cerebrospinal fluid for neurosurgeons, neurologists, and neuroscientists. Knowledge of the cerebrospinal fluid (CSF) and the subarachnoid space is necessary for almost all fields of medicine. The book covers a wide swath of topics related to CSF with a focus on topics relevant to neuroscience specialists including researchers, neurologists, neurosurgeons, and neuroradiologists. Topics span from neuroanatomy, neurophysiology, CSF in different disease states and more. Various fresh and fixed cadaveric photographs helps readers obtain a better understanding of anatomy and complications related to CSF.

Key Features

  • First comprehensive book devoted to clinical anatomy of cerebrospinal fluid and subarachnoid space
  • Edited by neuro-anatomists and neurosurgeons, giving it a multimodal perspective
  • Nerves and vessels color-coded to differentiate from other tissues


Practitioners and researchers in neurology, neurosurgery and neuroanatomy Spine surgeons, anatomists, medical students, resident, fellows, nurses

Table of Contents

  • 1. Historical perspectives
    2. Development of the ventricles, choroid plexus and subarachnoid space
    3. Anatomy of the ventricles and subarachnoid spaces and cisterns
    4. Anatomy of choroid plexus, capillary endothelial cells, ependymal layer, pia and arachnoid granulations/villi, extracellular space
    5. Spinal punctures
    6. CSF in the animal kingdom
    7. Animal models for CSF testing
    8. CSF physiology: Production, circulation, absorption, function, extrachoroidal formation/absorption
    9. CSF and basal lymphatic system in mammals
    10. A new look at CSF circulation
    11. Virchow Robin spaces
    12. CSF and disposition of alpha synuclein
    13. CSF in pediatrics: prematurity, neonates, infants, and toddlers
    14. CSF imaging
    15. CSF in neurodegenerative disease processes
    16. CSF in trauma
    17. CSF in pregnancy
    18. CSF in space, high-altitude or deep sea diving
    19. CSF fluid replacement
    20. Glymphatic system and CSF
    21. Lymphatic system and CSF
    22. Blood brain barrier
    23. Intracranial/intraspinal pressure
    24. Intracranial pressure (ICP) in trauma and autoregulation
    25. ICP in slit ventricle syndrome
    26. ICP and over drainage
    27. Non invasive ICP monitoring
    28. NPH
    29. ICP in normal pressure hydrocephalus (NPH)
    30. Neuropsychological testing and NPH
    31. Shunt infections
    32. Shunt complications
    33. Drugs and CSF production and ICP
    34. Hydrocephalus treatment “historical perspective”
    35. Hydrocephalus and shunt valves
    36. Reasons for shunting and revision surgery: UK registry data
    37. Infections of CSF
    38. CSF and disease:
    a. Primary tumors vs brain metastases
    b. Carcinomatous meningitis
    c. Developmental disorders
    d. Neuromuscular disorders
    e. Neurodegenerative disorders
    f. Movement disorders
    g. Diseases of the spinal cord
    h. Epilepsy and seizures
    39. CSF and headaches
    40. CSF markers and exosomes
    41. CSF in Chiari I malformation
    42. CSF in Chiari II malformation
    43. Neurophysiological consequences of hydrocephalus
    44. Hemorrhage and hydrocephalus
    45. Arrested hydrocephalus
    46. Aqueductal stenosis
    47. Hydrocephalus and genetic disorders
    48. Biomarkers of hydrocephalus
    49. Long-term prognosis of fetal hydrocephalus
    50. Circumventricular organs
    51. Endoscopic third ventriculostomy and choroid plexus coagulation
    52. Failure of ETV
    53. Learning disabilities in hydrocephalus
    54. Hydrocephalus in craniosynostosis
    55. Syringomyelia
    56. Arachnoid cysts
    57. Neuro endoscopic anatomy
    58. Endoscopy technique
    59. Hydrocephalus in the developing world
    60. Economics of hydrocephalus
    61. Hydrocephalus and Fetal surgery for myelomeningocele
    62. Ventricular anatomy in Chiari II malformation
    63.Venous outflow obstruction and hydrocephalus
    64. CSF markers before and after shunting
    65. Spinal CSF compartments
    66. Ventricular access devices in neonatal hemorrhage
    67. Body position and lumbar CSF leak
    68. Spontaneous CSF leak
    69. Visual pathway and hydrocephalus
    70. Effect of decompressive craniectomy on CSF pulsatility
    71. Direct control of CSF pulsatility and its effect on cerebral blood Flow
    72. The pulsating brain
    73. Choroid plexus transport
    74. Amyloid, tau, alpha synuclein and CSF dynamics

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 19, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128195093

About the Editors

R. Shane Tubbs

R. Shane Tubbs
R. Shane Tubbs, MS, PA-C, PhD is a native of Birmingham, Alabama, USA and a is a clinical anatomist, author, editor, educator, and researcher. He is Professor of Neurosurgery, Neurology, Surgery, and Structural & Cellular Biology, Director of Surgical Anatomy at Tulane School of Medicine and Program Director of Anatomical Research in the Clinical Neuroscience Research Center at Tulane University School of Medicine, New Orleans, Louisiana and Department of Neurosurgery and Ochsner Neuroscience Institute Ochsner Health System, New Orleans, LA. He has multiple honorary professorships/faculty positions both in the US and abroad. Dr. Tubbs is President-elect of the American Association of Clinical Anatomists (AACA) and serves as its Journal’s (Clinical Anatomy) Editor-in-Chief. Dr. Tubbs’ research interests are centered around what has been termed “reverse translational anatomy research” where clinical/surgical problems are identified and solved/explained with anatomical studies. This investigative paradigm in anatomy has resulted in over 1,800 peer reviewed publications from his laboratory. Dr. Tubbs’ laboratory has made novel discoveries in human anatomy and in 2018, he was listed as a “hyperprolific author” in the journal Nature. Dr. Tubbs sits on the editorial board of over 10 anatomical journals and over 30 clinical journals and has reviewed for over 150 various scientific journals. He has authored/edited over 50 books and over 80 book chapters primarily in anatomical and neurosurgical textbooks. Lastly, Dr. Tubbs is Chair of the Federative International Programme on Anatomical Terminologies (FIPAT) and oversees six working groups dedicated to this topic. Under his leadership, the second edition of Terminologia Anatomica was just published.

Affiliations and Expertise

Professor and Program Director, Tulane University School of Medicine, New Orleans, Louisiana and Department of Neurosurgery and Ochsner Neuroscience Institute Ochsner Health System, New Orleans, LA

Joe Iwanaga

Joe Iwanaga, DDS, PhD, is a clinical anatomist and an oral and maxillofacial surgeon. He is the author of more than 400 articles in peer-reviewed journals. Dr. Iwanaga is a Councilor-at-Large of the American Association of Clinical Anatomists, and Coordinator of the FIPAT Oral Anatomy Working Group of the International Federation of Associations of Anatomists. He is a Dental, Oral and Maxillofacial Section editor of the journal Clinical Anatomy.

Affiliations and Expertise

Associate Professor of Neurosurgery and Neurology at Tulane University School of Medicine, New Orleans, Louisiana, USA. Associate Professor of Anatomy and Dental and Oral Medical Center at Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Elias Rizk

Dr. Rizk is a neurosurgeon at the Penn State Hershey Medical Center with a clinical specialty in pediatric peripheral nerve surgery. He has multiple publications on the PNS and is active in basic science research regarding peripheral nerve regeneration.

Affiliations and Expertise

Neurosurgeon, Pennsylvania State University, Hershey, PA, USA

Aaron Dumont

Aaron S. Dumont works at Tulane University in New Orleans, Louisiana, USA.

Affiliations and Expertise

Tulane University, New Orleans, Louisiana, USA

Anthony D'Antoni

Anthony V. D'Antoni works in the Department of Radiology at Weill Cornell Medicine, New York, NY, USA.

Affiliations and Expertise

Department of Radiology, Weill Cornell Medicine, New York, NY, USA

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