Central Adrenaline Neurons

Central Adrenaline Neurons

Basic Aspects and Their Role in Cardiovascular Functions

1st Edition - January 1, 1980

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  • Editors: Kjell Fuxe, Menek Goldstein, Bernt Hökfelt
  • eBook ISBN: 9781483154695

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Central Adrenaline Neurons: Basic Aspects and their Role in Cardiovascular Functions contains the proceedings of an international symposium held at The Wenner-Oren Center, Stockholm on August 27-28, 1979. The purpose of the meeting is to summarize the knowledge of central adrenaline neurons and their role in cardiovascular functions. Organized into four sections, this book begins with a discussion on the morphology, biochemistry, and pharmacology of central adrenaline neurons. Subsequent sections detail the cardiovascular functions of central catecholamine neurons and the effects of centrally acting drugs on sympathetic function in normotensive and hypertensive patients. An overview lecture of the concept of α- and β-adrenergic receptors is also shown.

Table of Contents

  • List of Participants


    Opening Address

    Section I The Morphology and Biochemistry of Central Adrenaline Neurons

    The Anatomy of Central Cardiovascular Neurons

    Histochemical Identification of Adrenaline Containing Cells with Special Reference to Neurons

    Distribution and Characterization of PNMT and Epinephrine in the CNS

    Section II The Pharmacology of Central Adrenaline Neurons

    The Use of Liquid Chromatography with Electrochemical Detection for the Determination of Adrenaline and Other Biogenic Monoamines in the CNS

    The Discovery of Potent Inhibitors of Phenylethanolamine N-Nethyltransferase (PNMT)

    Pharmacologic Modification of Adrenaline Neurons in Rat Brain

    Effect of DBH- and PNMT-Inhibition on Brain Adrenaline and Noradrenaline in Animals Exposed to Stress

    Putative Regulation of Brain Norepinephrine Neurons by Epinephrine: Electrophysiological Studies

    Section III Cardiovascular Functions of Central Catecholamine Neurons

    Central Control of the Sympathetic Nervous System in Experimental Hypertension

    Cardiovascular Effects of Piperoxan: A Putative Adrenaline Receptor Blocker

    α -Adrenoreceptors and the Action of Clinidine-like Drugs

    Catecholamines of the Nucleus tractus Solitarii and Blood Pressure Regulation

    On the Role of Central Adrenaline Neurons in Central Cardiovascular Regulation

    Effects of Antihypertensives and Other Drugs on Central Adrenaline Utilization

    Adrenergic Receptor Mechanisms in the Central Nervous System in Relation to Catecholamine Neurons

    Catecholamine-Stimulated Cyclic AMP Formation in Brainstem Nuclei of Normal Rats and Rats with Genetic Hypertension

    The Hypotensive Actions of Centrally Administered Adrenaline

    Brain Stem Adrenergic Neurons Participate in the Regulation of the Stress Response and in Genetic and Experimental Hypertension

    Changes in Hypothalamic Adrenaline during Hyper- and Hypotensive States

    The Role of Central Catecholamine Pathways in Spontaneous and Renal Hypertension in Rats

    Central Effect of Adrenergic Compounds on Cat Respiratory Mechanisms

    Overview Lecture

    Radioligand Binding Studies of Adrenergic Receptors

    Section IV Effects of Centrally Acting Drugs on Sympathetic Function in Normotensive and Hypertensive Patients

    Elevated Plasma Adrenaline, Age-Related Decrease in Beta-Adrenoceptor-Mediated Cardiovascular Functions and Increase in Alpha-Receptor-Mediated Vasoconstriction in Essential Hypertension

    The Contribution of Central and Peripheral Adrenoceptors to the Actions of Clonidine and Alpha Methyldopa in Man

    Effect of Clonidine, Metoprolol and Penbutolol on Plasma Catecholamines and Renin Activity in Response to Sympathetic Stimulation in Hypertensive Patients

    Subject Index

Product details

  • No. of pages: 362
  • Language: English
  • Copyright: © Pergamon 1980
  • Published: January 1, 1980
  • Imprint: Pergamon
  • eBook ISBN: 9781483154695

About the Editors

Kjell Fuxe

Affiliations and Expertise

Department of Histology, Karolinska Institutet

Menek Goldstein

Bernt Hökfelt

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