1. Clinical standpoint of cancer metastasis
2. Motility and tumor invasion in metastasis
3. Epithelial and mesenchymal states and their role in cancer metastasis signalling
4. Hypoxia-induced cancer metastasis signalling
5. Integrins in cancer metastases
6. miRNA mediated regulation of cancer metastasis
7. The Role of Myeloid-Derived Suppressor Cells in Cancer Progression
8. Modulation of endothelial cells for cancer metastasis
9. Vascular endothelial growth factor signalling in cancer metastasis
10. Wnt signalling in cancer metastasis
11. Notch signalling in cancer metastasis
12. GLI signalling in cancer metastasis
13. Mutant TP53 in cancer metastasis
14. CXCR4/CXCL12 in cancer metastasis
15. Role of tumor microenvironment in melanoma metastasis
16. Cancer secretome in cancer metastasis
17. Systems biology of cancer metastasis
18. Systems biology of metabolism in cancer metastasis
Cellular Signalling in Cancer Metastasis provides the reader with in-depth information on the cellular signalling mechanisms responsible for cancer metastasis. Cancer metastasis is the major cause of cancer-associated mortality. Understanding the cellular signalling mechanisms and molecules involved in cancer metastasis help devise better therapeutic interventions.
Cancer-associated deaths are mainly attributed to the dislodging of cells from the primary site of origin and establishment of colonies at distal secondary sites, termed metastasis. While there has been made significant progress in understanding the mechanisms responsible for metastasis, there is a lack of a comprehensive book compiling these aspects between one cover. This book fills that gap and provides vital information that could be exploited for the development of better therapeutics.
The book is intended to help any entry level researchers from graduation students, postdocs and early career scientists and is detailed enough to be considered by seasoned scientists. It provides the reader with the current knowledge available on the subject and stimulates others to take up investigations on understanding of cancer metastasis, as it is the cause of cancer-associated mortality and morbidity.
- Provides the reader with in-depth information on the cellular signalling mechanisms responsible for cancer metastasis
- Explains signalling pathways associated with metastasis ranging from clinical management of metastatic disease to systems biology approach
- Brings together the current knowledge on the signalling pathways and mechanisms responsible for the induction and progression of metastasis as well as compile of present therapeutic options and challenges
Cancer researchers, oncologists, graduate students
- No. of pages:
- © Academic Press 2019
- 1st August 2019
- Academic Press
- Paperback ISBN:
Dr. Hasseb Zubair’s research interest is focused on the signalling pathways that control cancer development and progression. Recently, using a combination of RNA-sequencing and bioinformatics tools he has demonstrated the potential cellular networks perturbed by c-MYB in pancreatic cancer. c-MYB has been identified to exert oncogenic properties to different types of cancer, however the molecular pathways underlying these phenotypes are not completely understood. Dr Zubair’s research team are now underway to investigate the role of the c-MYB-modulated signalling pathways in progression and metastasis. In a much recent accomplishment, his research article has been accepted in the journal Cancer Research in which he has demonstrated a novel signalling axis responsible for the stabilization and up regulation of c-MYC transcription factor in pancreatic cancer. In addition, Dr. Zubair has been studying the cancer therapeutic and preventive properties of natural products. He has demonstrated that mobilization of endogenous cellular copper ions by these plant derived antioxidant leads to the generation of reactive oxygen species which act as proximal DNA damaging agents inducing cell death.
Research Scientist, University of South Alabama Mitchell Cancer Institute, USA