Cellular Signalling in Cancer Metastasis

Cellular Signalling in Cancer Metastasis

1st Edition - December 1, 2019

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  • Editor: Haseeb Zubair
  • Paperback ISBN: 9780128141939

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Cellular Signalling in Cancer Metastasis provides the reader with in-depth information on the cellular signaling mechanisms responsible for cancer metastasis. While significant progress has been made in understanding the mechanisms responsible for metastasis, the lack of a comprehensive book compiling these aspects was necessary, hence the development of this timely resource. This book is intended to help entry level researchers, from graduate students, postdocs and early career scientists, but is detailed enough to be considered by seasoned scientists. It provides the reader with the current knowledge available on the subject and stimulates others to take up investigations on understanding cancer metastasis.

Key Features

  • Provides readers with in-depth information on the cellular signaling mechanisms responsible for cancer metastasis
  • Explains the signaling pathways associated with metastasis, ranging from clinical management of metastatic disease, to a systems biology approach
  • Brings together the current knowledge on signaling pathways and the mechanisms responsible for the induction and progression of metastasis, along with present therapeutic options and challenges


Cancer researchers, oncologists, graduate students

Table of Contents

  • 1. Clinical standpoint of cancer metastasis
    2. Motility and tumor invasion in metastasis
    3. Epithelial and mesenchymal states and their role in cancer metastasis signalling
    4. Hypoxia-induced cancer metastasis signalling
    5. Integrins in cancer metastases
    6. miRNA mediated regulation of cancer metastasis
    7. The Role of Myeloid-Derived Suppressor Cells in Cancer Progression
    8. Modulation of endothelial cells for cancer metastasis
    9. Vascular endothelial growth factor signalling in cancer metastasis
    10. Wnt signalling in cancer metastasis
    11. Notch signalling in cancer metastasis
    12. GLI signalling in cancer metastasis
    13. Mutant TP53 in cancer metastasis
    14. CXCR4/CXCL12 in cancer metastasis
    15. Role of tumor microenvironment in melanoma metastasis
    16. Cancer secretome in cancer metastasis
    17. Systems biology of cancer metastasis
    18. Systems biology of metabolism in cancer metastasis

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2029
  • Published: December 1, 2019
  • Imprint: Academic Press
  • Paperback ISBN: 9780128141939

About the Series Volume Editor

Haseeb Zubair

Dr. Hasseb Zubair’s research interest is focused on the signalling pathways that control cancer development and progression. Recently, using a combination of RNA-sequencing and bioinformatics tools he has demonstrated the potential cellular networks perturbed by c-MYB in pancreatic cancer. c-MYB has been identified to exert oncogenic properties to different types of cancer, however the molecular pathways underlying these phenotypes are not completely understood. Dr Zubair’s research team are now underway to investigate the role of the c-MYB-modulated signalling pathways in progression and metastasis. In a much recent accomplishment, his research article has been accepted in the journal Cancer Research in which he has demonstrated a novel signalling axis responsible for the stabilization and up regulation of c-MYC transcription factor in pancreatic cancer. In addition, Dr. Zubair has been studying the cancer therapeutic and preventive properties of natural products. He has demonstrated that mobilization of endogenous cellular copper ions by these plant derived antioxidant leads to the generation of reactive oxygen species which act as proximal DNA damaging agents inducing cell death.

Affiliations and Expertise

Research Scientist, University of South Alabama Mitchell Cancer Institute, USA

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