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Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration.
- Features leading experts in various subfields as section editors and article authors
- Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship
- Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration
- Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Neuroscience, developmental biology researchers, including stem cells, aging, and diseases. Translational neuroscience researchers
I: FORMATION OF AXONS AND DENDRITES
1. Development of Neuronal Polarity In Vivo
2. Role of the Cytoskeleton and Membrane Trafficking in Axon–Dendrite Morphogenesis
Kevin C. Flynn and Frank Bradke
3. Axon Growth and Branching
4. Netrins and guidance
5. Axon Guidance: Semaphorin/Neuropilin/Plexin Signaling
M.G.Verhagen & R.J. Pasterkamp
6. Ephrin/Eph Signaling in Axon Guidance
7. Axon Guidance: Slit–Robo Signaling
8. Nonconventional Axon Guidance Cues
Patricia T. Yam and Frederic Charron
9. Axon Regeneration
10. Axon Maintenance and Degeneration
Zhigang He and Fan Wang
11. Dendrite Development: Invertebrates
12. Dendritic Development: Vertebrates
Julie L. Lefebvre
13. Cell Polarity and Initiation of Neuronal Migration
Kanehiro Hayashi and Kazunori Nakajima
Orly Reiner and Eyal Karzburn
15. Radial Migration in the Developing Cerebral Cortex
16. Tangential Migration in the Forebrain
Carla G. Silva, Fanny Lepiemme and Laurent Nguyen
17. Migration in the Hippocampus
18. Hindbrain Tangential Migration
Constantino Sotelo and Alain Chedotal
19. Neuronal Migration in the Cerebellum
20. Neuronal Migration of Guidepost Cells and Brain Patterning
21. Adult Neuronal Migration
22. Transcriptional and Post Transcriptional Mechanisms of Neuronal Migration
23. Migration of Myelin-Forming Cells in the CNS
24. Coordination of Different Modes of Neuronal Migration and Functional Organization of the Cerebral Cortex
Holden R. Higginbotham
25. The Impact of Different Modes of Neuronal Migration on Brain Evolution
Fernando Garcia-Moreno and Zoltan Molnar
26. Neuronal Migration Disorders
Joseph LoTurco and Jean-Bernard Manent
- No. of pages:
- © Academic Press 2020
- 30th May 2020
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Dr. Rubenstein is a Professor in the Department of Psychiatry at the University of California, San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain. Dr. Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.
Professor, Department of Psychiatry, University of California, San Francisco, USA
Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations. He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.
Department of Neuroscience, Yale School of Medicine, USA
Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.
Professor of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, USA
Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.
Assistant Professor of Human Genetics and Research Assistant Professor, Molecular and Behavioral Neuroscience Institute, University of Michigan, USA
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