Cellular Migration and Formation of Neuronal Connections - 2nd Edition - ISBN: 9780128144077

Cellular Migration and Formation of Neuronal Connections

2nd Edition

Comprehensive Developmental Neuroscience

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Editor-in-Chiefs: John Rubenstein Pasko Rakic
Editors: Bin Chen Kenneth Kwan
Hardcover ISBN: 9780128144077
Imprint: Academic Press
Published Date: 1st June 2020
Page Count: 1100
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Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites, migration, synaptogenesis, and developmental sequences in the maturation of intrinsic and synapse-driven patterns.

Key Features

  • Features leading experts in various subfields as section editors and article authors
  • Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship
  • Includes coverage of mechanisms which regulate the formation of axons and dendrites, cell migration, synapse formation and maintenance during development
  • Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity


Neuroscience, developmental biology researchers, including stem cells, aging, and diseases. Translational neuroscience researchers

Table of Contents

I: Formation of Axons and Dendrites
1. Development of Neuronal Polarity In Vivo
F. Polleux
2. Role of the Cytoskeleton and Membrane Trafficking in Axon–Dendrite Morphogenesis
K.C. Flynn, M. Stiess, F. Bradke
3. Axon Growth and Branching
L. Ma, D.A. Gibson
4. Axon Guidance: Semaphorin/Neuropilin/Plexin Signaling
J. Falk, V. Castellani
5. Roles of Eph–Ephrin Signaling in Axon Guidance
A.D. Chisholm, D.A. Feldheim
6. Axon Guidance: Slit–Robo Signaling
F. Beaubien, J.E.A. Prince, J.-F. Cloutier
7. Nonconventional Axon Guidance Cues
L. Izzi, F. Charron
8. Axon Regeneration
T.L. Dickendesher, Y. Duan, R.J. Giger
9. Axon Maintenance and Degeneration
F. Wang, Z. He
10. Dendrite Development: Invertebrates
W.B. Grueber
11. Dendritic Development: Vertebrates
C. Lohmann

II: Migration
12. Cell Polarity and Initiation of Migration
13. Leading Process Dynamics During Neuronal Migration
M. Valdeolmillos, F. Moya
14. Nucleokinesis
O. Reiner, G. Gerlitz
15. Migration in the Cerebellum
Y. Komuro, T. Kumada, N. Ohno, K.D. Foote, H. Komuro
16. Radial Migration in the Developing Cerebral Cortex
S.C. Noctor, C.L. Cunningham, A.R. Kriegstein
17. Radial Migration of Neurons in the Cerebral Cortex
A. Stanco, E.S. Anton
18. Migration in the Hippocampus
G. Li, S.J. Pleasure
19. Hindbrain Tangential Migration
C. Sotelo, A. Chedotal
20. Tangential Migration: The Forebrain
T.J. Petros, S.A. Anderson
21. Transcriptional Regulation of Tangential Neuronal Migration in the Vertebrate Hindbrain
T. Di Meglio, F.M. Rijli
22. Postnatal Neurogenesis of the Forebrain
R. Belvindrah, P.-M. Lledo
23. Migration of Myelin-Forming Cells in the CNS
F. de Castro, B. Zalc
24. Neuronal Migration and Brain Patterning
A. Griveau, U. Borello, A. Pierani
25. Neuronal Migration of Guidepost Cells
F. Bielle, S. Garel
26. Neuronal Migration Disorders
J.J. LoTurco, A.B. Booker

III: Synaptogenesis
27. Molecular Composition of Developing Glutamatergic Synapses
S.L. Barrow, A.K. McAllister
28. In Vivo Imaging of Synaptogenesis
M. Munz, E.S. Ruthazer
29. Genetic Analysis of Synaptogenesis
C.S. Lu, D. Van Vactor
30. Activity-Regulated Genes and Synaptic Plasticity
J.H. Leslie, E. Nedivi
31. New Imaging Tools to Study Synaptogenesis
S.J. Le Marchand, M.B. Dalva
32. Wnt Signaling
P.C. Salinas
33. Neurotrophins and Synaptogenesis
F. Jeanneteau, M.V. Chao
34. Ephrins and Eph Receptors – Synaptogenesis and Synaptic Function
A. Filosa, R. lein
35. Neuroligins and Neurexins
D. Schreiner, P. Scheiffele
36. Circuit Assembly in the Developing Vertebrate Retina
T. Yoshimatsu, S.C. Suzuki, R.O.L. Wong
37. Synaptogenesis in the Adult CNS – Neocortical Plasticity
R. Eavri, E. Nedivi
38. Synaptogenesis in the Adult CNS – Hippocampus
C. Zhao, N. Toni, F.H. Gage
39. Synaptogenesis in the Adult CNS–Olfactory System
A. Mizrahi
40. Synaptogenesis and Recovery from Cortical Trauma
R.J. Nudo, D. McNeal
41. Local translation in synaptogenesis
Christine Holt
42. Cadherin Code
Joshua Sanes/Xin Duan
43. Microglia and synapse pruning
Beth Stevens
44. Astrocytes and synaptogenesis
Cagla Eroglu

IV: Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns
45. GABA: A Multifacet Device that Exerts a Crucial Role in Brain Development
Y. Ben-Ari
46. Lessons from Zebrafish: Ion Channels Guide Neuronal Developmen
T.C. Martin, A.B. Ribera
47. Regulation of AMPA-Type Glutamate Receptor Trafficking
Boekhoorn, C.C. Hoogenraad
48. Pre- and Postsynaptic Assembly and Maturation: Principal Mechanisms and Coordination
S.J. Sigrist, C. Wichmann
49. Cajal–Retzius and Subplate Cells: Transient Cortical Neurons and Circuits
H.J. Luhmann
50. Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions
A. Fukuda
51. GABAergic Signaling at Newborn Mossy Fiber–CA3 Synapses: Short- and Long-Term Activity-Dependent Plasticity Processes
E. Cherubini
52. BDNF and the Plasticity of Brain Networks During Maturation
J.-L. Gaiarsa
53. Retinal Waves: Underlying Cellular Mechanisms and Theoretical Considerations
E. Sernagor, M.H. Hennig
54. Multimodal GABAA Receptor Functions on Cell Development
A. Fukuda, Y. Nakanishi, T. umada, T. Furukawa
55. Retinal Waves and their Role in Visual System Development
M.B. Feller, D. erschensteiner
56. The Maturation of Firing Properties of Forebrain GABAergic Interneurons
B.W. Okaty, S.B. Nelson
57. Multiple Roles of CC2 in the Developing Brain
P. Uvarov, O. Llano, A. Ludwig, M.S. Airaksinen, C. Rivera
58. NKCC1 and Brain Maturation
C.K. Pfeffer, C.A. Hübner
59. Maturation of Inhibitory Synaptic Transmission in the Spinal Cord: Role of the Brain Stem and Contribution to the Development of Motor Patterns
L. Vinay
60. Calcium Signals Regulate Neurotransmitter Phenotype
M. Demarque, N.C. Spitzer
61. Compensation mechanisms
Gina Turrigiano


No. of pages:
© Academic Press 2020
1st June 2020
Academic Press
Hardcover ISBN:

About the Editor-in-Chief

John Rubenstein

Dr. Rubenstein is a Professor in the Department of Psychiatry at the University of California, San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain. Dr. Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.

Affiliations and Expertise

University of California, San Francisco, USA

Pasko Rakic

Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations. He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.

Affiliations and Expertise

Yale University, USA

About the Editor

Bin Chen

Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.

Affiliations and Expertise

University of California, Santa Cruz, USA

Kenneth Kwan

Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.

Affiliations and Expertise

University of Michigan, USA

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