Cellular Endocrinology in Health and Disease

1st Edition

Editors: Alfredo Ulloa-Aguirre P. Michael Conn
Hardcover ISBN: 9780124081345
eBook ISBN: 9780124167124
Imprint: Academic Press
Published Date: 3rd April 2014
Page Count: 414
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Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue.

Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and P. Michael Conn, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts. 

Key Features

  • Covers systemic endocrine action at the cellular level in both health and disease
  • Delivers information on the integration of cell identity and endocrinology
  • Incorporates recent developments in endocrinology to provide an up-to-date reference to researchers


Researchers in cell biology, biochemistry, endocrinology, graduate students and researchers across basic sciences and biomedicine

Table of Contents

List of Contributors


Chapter 1. Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer

Thyroid Hormone Action

TRs and Cancer

Inhibition of Tumor Cell Proliferation by the Thyroid Hormone Receptors

The Thyroid Hormone Receptor Antagonizes Ras-Induced Proliferation

The Thyroid Hormone Receptors Antagonize Transformation and Tumorigenesis by Oncogenic Ras

Functional Domains Involved in TR Antagonism of Ras Responses

TRβ1 Suppresses Tumor Invasion and Metastasis

Hypothyroidism Retards Tumor Growth but Increases Metastasis Development

Divergent Effects of TRs on Normal and Transformed Cell Proliferation



Chapter 2. The Molecular Cell Biology of Anterior Pituitary Cells


Anterior Pituitary: Organization, Cell Types, Hormones and Functions

Diseases of the Anterior Pituitary

Phenotypic Profile of Anterior Pituitary Cell Types: Different, Yet Somewhat Similar

Heterogeneity within Anterior Pituitary Cell Types: Similar, Yet Somewhat Different

Patterns of Anterior Pituitary Cell Signaling and Secretion

Paracrine (Local) Regulation and Intercellular Signaling within the Anterior Pituitary

Plasticity of Anterior Pituitary Cell Network Organization and Function

Concluding Remarks



Chapter 3. Sensing Calcium Levels: The Biology of the Parathyroid Cell


Biosynthesis and Metabolism of PTH

Regulation of PTH Secretion and Transcription

Main Mechanisms of Parathyroid Gland Hyperplasia in SHPT



Chapter 4. The Biology of Pituitary Stem Cells


Location of Proliferating and Differentiating Cells During Pituitary Development

Strategies for Identifying Pituitary Pr


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About the Editor

Alfredo Ulloa-Aguirre

Alfredo Ulloa-Aguirre, M.D., D.Sc. is senior scientist in the Research Center for Population Health at the National Institute of Public Health and Professor of the National University of Mexico (UNAM), where he heads the Research Support Network of the National Institutes of Health in Mexico City. He received his graduate training in internal medicine and reproductive endocrinology at the National Institute of Medical Sciences and Nutrition SZ and earned the Doctoral degree in Medical Sciences from the UNAM. He received postdoctoral training at the University of Pennsylvania, Philadelphia PA, and has been visiting scientist at the Oregon National Primate Resarch Center, OHSU, Beaverton OR, and the Institut National de la Recherche Agronomique, in Tours, France (Le Studium Scientist). He is currently a member of the Studium Consortium for Research and Training in Reproductive Sciences (sCORTS, Le Studium, Orléans, France). An internationally recognized physician-scientist, Dr Ulloa-Aguirre has developed programmes in both clinical and basic research. His laboratory focuses on the structure-function relationship of gonadotropins and gonadotropin receptors as well as on the gonadotropin-releasing hormone receptor, with particular emphasis on the factors and mechanisms that control intracellular trafficking of these receptors. He is the author or co-author of over 165 research publications and several book chapters.

Affiliations and Expertise

Research Center for Population Health, National Institute of Public Health; National University of Mexico (UNAM), Mexico City, Mexico

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA