Cellular and Molecular Mechanisms of Inflammation

Cellular and Molecular Mechanisms of Inflammation

Signal Transduction in Inflammatory Cells, Part A

1st Edition - June 10, 1992

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  • Editors: Charles G. Cochrane, Michael A. Gimbrone
  • eBook ISBN: 9781483191539

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Cellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A is a collection of papers that discusses the mechanisms of the transduction of signals linking stimulated receptors and cellular function. This book describes the pathways of signal transduction involved in stimulating functions of inflammatory cells connected with host defense and development of inflammatory injury. One paper notes the potential of using fluorescence methodology in analyzing ligand-receptor interactions in living systems during the natural abundance of cell surface receptors. Another paper discusses the structure and function of GTP-binding proteins in neutrophil signal transduction, particularly the role of oligomeric G proteins in signal transduction. One concern in signal transduction research is the physiological significance of the presence of multiple forms of proteins that can have identical functions. One paper reviews phosphatidylcholine breakdown and hormone action in the rat liver, focusing on G proteins and on inositol phospholipid breakdown. This book also discusses calcium translocation in signal transduction, as well as, a novel signal transduction pathway involving phosphatidylinositol 3-kinase. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

Table of Contents

  • Preface

    Chapter 1 Real-Time Analysis of Ligand-Receptor Dynamics and Binding Pocket Structure of the Formyl Peptide Receptor 1


    Birth of Real-Time Assays for Neutrophil Receptor Dynamics

    Early Methods 1980-1985

    Receptor-G Protein Interactions

    Intact Cell


    Ligand-Receptor Dynamics for Unlabeled Ligands

    Receptor Binding Pocket Topography

    Prospects for Generalizing Real-Time Methods for Kinetic and Structural Analyses


    Chapter 2 Structure and Function of GTP-Binding Proteins in Neutrophil Signal Transduction


    Oligomeric G Proteins

    Neutrophil G Proteins

    Low-Molecular-Weight G Proteins

    LMWGs in Neutrophils

    G Protein Regulation of Oxidant Production in Neutrophils

    Summary and Conclusions


    Chapter 3 Regulation of Phospholipase C Isozymes

    Activation of PLC by G Protein-Dependent and -Independent Pathways

    Heterogeneity in the PI Response to Specific Ligands

    Multiple Forms of PLC

    G Protein-Dependent Activation of PLC

    G Protein-Dependent Inhibition of PLC

    Activation of PLC by Growth Factor Receptor Tyrosine Kinases

    Activation of PLC-γ1 Through Tyrosine Phosphorylation by Nonreceptor PTK



    Chapter 4 Phosphatidylcholine Metabolism in Signal



    Liver as an Experimental System

    Diacylglycerol Accumulation

    Phosphatidate Accumulation

    In Vivo Measurements of DAG and PA in the Regenerating Liver

    Role of DAG and PA in Liver Function

    Future Directions


    Chapter 5 Calcium Translocation in Signal Transduction


    Ca2+ Signal; Studies in Cell Populations and Single Neutrophils

    Neutrophil Plasma Membrane: Ion Channels, Membrane Potential, and Ca2+ Influx

    Intracellular Ca2+ Stores in Myeloid Cells

    Phosphatidylinositol Turnover

    Role of [Ca2+]i in the Regulation of Neutrophil Functions

    Concluding Remarks


    Chapter 6 Inositol Phosphate Metabolism

    Introduction to Phosphatidylinositol Turnover

    Discovering the Biological Role of Inositol Phosphates

    Interconversion of the Phosphatidylinositols

    Ptdlns 3-Kinase

    Production of Inositol Phosphates

    Ptdlns-Specific PLC

    Cyclic Inositol Phosphate Pathway

    Cyclic Hydrolase

    Ins(1,4,5)P3/Ins(1,3,4,5)P4 Pathway

    Possible Functions of Ins(1,3,4,5)P4

    Ins(1,4,5)P3 3-Kinase

    Inositol Polyphosphate 5-Phosphatase

    Other Pathways of Inositol Phosphate Metabolism

    Inositol Polyphosphate 1-Phosphatase

    Inositol Polyphosphate 4-Phosphatase

    Inositol Polyphosphate 3-Phosphatase

    Phosphorylation of Ins(1,3,4)P3


    Closing Comments


    Chapter 7 Phosphatidylinositol 3-Kinase: A Novel Signal Transduction Pathway?


    Pathway and Structures for the Conventional Polyphosphoinositides

    A Distinct Phosphatidylinositol Kinase Associates with Activated Protein Tyrosine Kinases

    Phosphatidylinositol 3-Kinase Is Linked to Cell Proliferation and Transformation

    Discovery of Other Novel Polyphosphoinositides

    Critical Determinants for Association of Phosphatidylinositol 3-Kinase and Protein Tyrosine Kinases




Product details

  • No. of pages: 218
  • Language: English
  • Copyright: © Academic Press 1992
  • Published: June 10, 1992
  • Imprint: Academic Press
  • eBook ISBN: 9781483191539

About the Editors

Charles G. Cochrane

Michael A. Gimbrone

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