Cellular and Molecular Mechanisms of Inflammation - 1st Edition - ISBN: 9780121504014, 9781483191515

Cellular and Molecular Mechanisms of Inflammation

1st Edition

Receptors of Inflammatory Cells: Structure—Function Relationships

Editors: Charles G. Cochrane Michael A. Gimbrone
eBook ISBN: 9781483191515
Imprint: Academic Press
Published Date: 28th November 1990
Page Count: 266
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Description

Receptors of Inflammatory Cells: Structure-Function Relationships is the first in a new serial on Cellular and Molecular Mechanisms of Inflammation. The purpose of this serial is to bring together the latest knowledge in various areas of research in this actively developing field around a topical focus. These volumes are not intended to present comprehensive reviews. Rather, each contribution is meant to be a status report from laboratories actively working in an area.

This volume presents an analysis of the structure-function relationships of receptors. It is clear that the structure of receptors provides the initial guidance for numerous functions of each cell in the organism. Through an analysis of the submolecular features of the receptors that are responsible for the initiation of activity of diverse biochemical pathways within the cells, a molecular understanding of the all important initial, guiding events of cell functions will emerge. In the broad sense of cells involved in inflammation, this includes mitogenesis, gene transcription, generation of lipid metabolites and oxidants, clearance of molecules from the surrounding medium, and release of granular constituents from cytoplasmic vesicles into the external medium, among others.

The contents of this first volume will serve as a foundation for the subject of the second volume, which is signal transduction. Four additional volumes are in preparation, including Endothelial Leukocyte-Adhesion Molecules, Leukocyte Adhesive Mechanisms in Inflammation and Immunity, a second volume on Signal Transduction, and Stimulation of Inflammatory Cells.

Table of Contents


Preface


Chapter 1 FCγ Receptors: A Diverse and Multifunctional Gene Family


Introduction


Nomenclature


huFcγRI


huFcγRII


huFcγRIII


moFcγRI


moFcγRII


FcγR Cycling


FcγR Signaling


Soluble FcγRs


Autoimmunity


References


Chapter 2 Genetic Analysis of β-Adrenergic Receptor Structure and Function


Introduction


Receptor Structure


Ligand-Binding Domain


G Protein Coupling


Conclusions and Future Directions


References


Chapter 3 CR1 and CR2: Receptors Mediating Cellular Recognition in the Complement System


Overview


CR1


CR2


References


Chapter 4 N-Formyl Peptide Receptor Structure-Function Relationships


Introduction


Receptor Purification and Reconstitution


Physicochemical Properties of the Receptor


Receptor Structure


Receptor Heterogeneity


Control of Cell Surface Receptor Numbers


Cellular Processing of Receptor and Ligand


Molecular Interactions of the Receptor


Summary


References


Chapter 5 Influenza A Virus Activation of the Human Neutrophil: A Case of Promiscuous Binding?


Introduction


Hemagglutinin Structure


Hemagglutinin and Its Receptor


Effect of Competing Sugars on Neutrophil Activation by IAV and Other Stimuli


Effects of Preincubation with Neuraminidase on Neutrophil Activation by IAV and WGA


Viral Binding


Discussion


References


Chapter 6 Structure and Function of Murine and Human IL-1 Receptors


Introduction


Structure of Murine and Human IL-1 Recepto

Details

No. of pages:
266
Language:
English
Copyright:
© Academic Press 1990
Published:
Imprint:
Academic Press
eBook ISBN:
9781483191515

About the Editor

Charles G. Cochrane

Michael A. Gimbrone

Ratings and Reviews