Cellular and Molecular Immunology

Cellular and Molecular Immunology

10th Edition - February 19, 2021

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  • Authors: Abul Abbas, Andrew Lichtman, Shiv Pillai
  • eBook ISBN: 9780323757508
  • Paperback ISBN: 9780323757485

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Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists.

Table of Contents

  • Instructions for online access
  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Preface
  • Online Resources for Instructors and Students
  • Chapter 1. Properties and Overview of Immune Responses
  • Innate and Adaptive Immunity
  • Innate Immunity
  • Adaptive Immunity
  • Summary
  • Chapter 2. Cells and Tissues of the Immune System
  • Cells of the Immune System
  • Anatomy and Functions of Lymphoid Tissues
  • Summary
  • Chapter 3. Leukocyte Circulation and Migration Into Tissues
  • Overview of Leukocyte Migration
  • Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
  • Chemokines and Chemokine Receptors
  • Leukocyte-Endothelial Interactions and Leukocyte Recruitment into Tissues
  • Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
  • Migration and Recirculation of T Lymphocytes
  • Migration of B Lymphocytes
  • Summary
  • Chapter 4. Innate Immunity
  • Overview of Innate Immunity
  • Recognition of Microbes and Damaged Tissue by the Innate Immune System
  • Cellular Pattern Recognition Receptors
  • Cellular Components of the Innate Immune System
  • Soluble Effector Molecules of Innate Immunity
  • The Inflammatory Response
  • The Antiviral Response
  • Stimulation of Adaptive Immunity
  • Mechanisms that Limit Innate Immune Responses
  • Summary
  • Chapter 5. Antibodies and Antigens
  • Antibody Structure
  • Synthesis, Assembly, and Expression of Immunoglobulin Molecules
  • Antibody Binding of Antigens
  • Structure-Function Relationships in Antibody Molecules
  • Summary
  • Chapter 6. Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules
  • Properties of Antigens Recognized by T Lymphocytes
  • Antigen Capture and the Functions of Antigen-Presenting Cells
  • The Major Histocompatibility Complex
  • Processing of Protein Antigens
  • Presentation of Nonprotein Antigens to T Cells
  • Summary
  • Chapter 7. Immune Receptors and Signal Transduction
  • Overview of Signal Transduction
  • The Immune Receptor Family
  • The T Cell Receptor Complex and T Cell Signaling
  • The B Lymphocyte Antigen Receptor Complex
  • The Attenuation of Immune Receptor Signaling
  • Cytokine Receptors and Signaling
  • Summary
  • Chapter 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement
  • Overview of Lymphocyte Development
  • Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
  • B Lymphocyte Development
  • T Lymphocyte Development
  • Summary
  • Chapter 9. Activation of T Lymphocytes
  • Overview of T Lymphocyte Activation
  • Signals for T Lymphocyte Activation
  • Functional Responses of T Lymphocytes
  • Decline of T Cell Responses
  • Summary
  • Chapter 10. Differentiation and Functions of CD4+ Effector T Cells
  • Overview of CD4+ T Cell–Mediated Immune Responses
  • Subsets of CD4+ Effector T Cells
  • The Th1 Subset
  • The Th2 Subset
  • The Th17 Subset
  • Functions of Other HELPER T Cell Subsets
  • Summary
  • Chapter 11. Differentiation and Functions of CD8+ Effector T Cells
  • Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes
  • Effector Functions of CD8+ Cytotoxic T Lymphocytes
  • Cytokine Production by CD8+ Effector T Cells
  • Roles of CD8+ Cytotoxic T Lymphocytes in Host Defense
  • Summary
  • Chapter 12. B Cell Activation and Antibody Production
  • Overview of Humoral Immune Responses
  • Antigen Recognition and Antigen-Induced B Cell Activation
  • Helper T Cell–Dependent Antibody Responses to Protein Antigens
  • Antibody Responses to T-Independent Antigens
  • Antibody Feedback: Regulation of Humoral Immune Responses By Fc Receptors
  • Summary
  • Chapter 13. Effector Mechanisms of Humoral Immunity
  • Overview of Humoral Immunity
  • Neutralization of Microbes and Microbial Toxins
  • Antibody-Mediated Opsonization and Phagocytosis
  • The Complement System
  • Summary
  • Chapter 14. Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
  • General Features of Immunity at Epithelial Barriers
  • Immunity in the Gastrointestinal System
  • Immunity in Other Mucosal Tissues
  • The Cutaneous Immune System
  • Immune-Privileged Tissues
  • Immunity in the Mammalian Fetus and Newborn
  • Summary
  • Chapter 15. Immunologic Tolerance and Autoimmunity
  • Overview of Immunologic Tolerance
  • T Lymphocyte Tolerance
  • B Lymphocyte Tolerance
  • Tolerance to Commensal Microbes and Other Foreign Antigens
  • Mechanisms of Autoimmunity
  • Summary
  • Chapter 16. Immunity to Microbes
  • Overview of Immune Responses to Microbes
  • Immunity to Extracellular Bacteria
  • Immunity to Intracellular Bacteria
  • Immunity to Fungi
  • Immunity to Viruses
  • Immunity to Parasites
  • Strategies for Vaccine Development
  • Summary
  • Chapter 17. Transplantation Immunology
  • General Principles of Transplantation Immunology
  • Immune Responses to Allografts
  • Patterns and Mechanisms of Allograft Rejection
  • Prevention and Treatment of Allograft Rejection
  • Xenogeneic Transplantation
  • Blood Transfusion and the Abo and Rh Blood Group Antigens
  • Hematopoietic Stem Cell (HSC) Transplantation
  • Summary
  • Chapter 18. Tumor Immunology
  • Overview of Tumor Immunity
  • Tumor Antigens
  • Immune Responses To Tumors
  • Evasion of Immune Responses by Tumors
  • Immunotherapy For Tumors
  • Summary
  • Chapter 19. Hypersensitivity Disorders
  • Causes of Hypersensitivity Diseases
  • Mechanisms and Classification of Hypersensitivity Reactions
  • Diseases Caused by Antibodies and Antigen-Antibody Complexes
  • Diseases Caused by T Lymphocytes
  • Therapeutic Approaches for Immunologic Diseases
  • Selected Immunologic Diseases: Pathogenesis and Therapeutic Strategies
  • Summary
  • Chapter 20. Allergy
  • Overview of IgE-Dependent Allergic Reactions
  • Production of IgE
  • Cells Involved in Allergic Reactions
  • Reactions Dependent on IgE and Mast Cells
  • Genetic Susceptibility to Allergic Disease
  • Allergic Diseases in Humans: Pathogenesis and Therapy
  • The Protective Roles of Immune Reactions Mediated by IgE and Mast Cells
  • Summary
  • Chapter 21. Primary and Acquired Immunodeficiencies
  • Overview of Immunodeficiency Diseases
  • Primary (Congenital) Immunodeficiencies
  • Secondary (Acquired) Immunodeficiencies
  • Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
  • Summary
  • Glossary
  • Appendix I. Principal Features of Selected CD Molecules
  • Appendix II. Cytokines
  • Appendix III. Laboratory Techniques Commonly Used in Immunology
  • Index

Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: February 19, 2021
  • Imprint: Elsevier
  • eBook ISBN: 9780323757508
  • Paperback ISBN: 9780323757485

About the Authors

Abul Abbas

Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Affiliations and Expertise

Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Andrew Lichtman

Affiliations and Expertise

Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Shiv Pillai

Affiliations and Expertise

Massachusetts General Hospital Cancer Center, Boston, MA, USA

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