Cellular and Molecular Immunology

Cellular and Molecular Immunology

9th Edition - December 26, 2016

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  • Authors: Abul Abbas, Andrew Lichtman, Shiv Pillai
  • eBook ISBN: 9780323523233
  • Paperback ISBN: 9780323479783

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The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The 9th Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.

Key Features

  • Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout.
  • Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program.
  • Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
  • Includes summary boxes that assist with rapid review and mastery of key material.
  • Student Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references and animations, designed to produce a more rounded learning experience.

Table of Contents

  • Cover image
  • Title Page
  • Table of Contents
  • Copyright
  • Dedication
  • Preface
  • Online Resources for Instructors and Students
  • Resources for Instructors
  • Resources for Students
  • 1 Properties and Overview of Immune Responses
  • Innate and Adaptive Immunity
  • Innate Immunity: the Early Defense
  • Adaptive Immunity
  • Summary
  • Selected Readings
  • 2 Cells and Tissues of the Immune System
  • Cells of the Immune System
  • Anatomy and Functions of Lymphoid Tissues
  • Summary
  • Selected Readings
  • 3 Leukocyte Circulation and Migration into Tissues
  • Overview of Leukocyte Migration
  • Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
  • Chemokines and Chemokine Receptors
  • Leukocyte-Endothelial Interactions and Leukocyte Recruitment Into Tissues
  • Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
  • Migration and Recirculation of T Lymphocytes
  • Migration of B Lymphocytes
  • Summary
  • Selected Readings
  • 4 Innate Immunity
  • Overview of Innate Immunity
  • Recognition of Microbes and Damaged Self by the Innate Immune System
  • Cell-Associated Pattern Recognition Receptors and Sensors of Innate Immunity
  • Cellular Components of the Innate Immune System
  • Soluble Effector Molecules of Innate Immunity
  • The Inflammatory Response
  • The Antiviral Response
  • Stimulation of Adaptive Immunity
  • Mechanisms That Limit Innate Immune Responses
  • Summary
  • Suggested Readings
  • 5 Antibodies and Antigens
  • Antibody Structure
  • Synthesis, Assembly, and Expression of Immunoglobulin Molecules
  • Antibody Binding of Antigens
  • Structure-Function Relationships in Antibody Molecules
  • Summary
  • Suggested Readings
  • 6 Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules
  • Properties of Antigens Recognized by T Lymphocytes
  • Antigen Capture and the Functions of Antigen-Presenting Cells
  • The Major Histocompatibility Complex
  • Processing of Protein Antigens
  • Presentation of Nonprotein Antigens to T Cells
  • Summary
  • Suggested Readings
  • 7 Immune Receptors and Signal Transduction
  • Overview of Signal Transduction
  • The Immune Receptor Family
  • The T Cell Receptor Complex and T Cell Signaling
  • The B Lymphocyte Antigen Receptor Complex
  • The Attenuation of Immune Receptor Signaling
  • Cytokine Receptors and Signaling
  • Summary
  • Suggested Readings
  • 8 Lymphocyte Development and Antigen Receptor Gene Rearrangement
  • Overview of Lymphocyte Development
  • Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
  • B Lymphocyte Development
  • T Lymphocyte Development
  • Summary
  • Suggested Readings
  • 9 Activation of T Lymphocytes
  • Overview of T Lymphocyte Activation
  • Signals for T Lymphocyte Activation
  • Functional Responses of T Lymphocytes
  • Decline of T Cell Responses
  • Summary
  • Selected Readings
  • 10 Differentiation and Functions of CD4+ Effector T Cells
  • Overview of CD4+ T Cell-Mediated Immune Responses
  • Subsets of CD4+ Effector T Cells
  • The Th1 Subset
  • The Th2 Subset
  • The Th17 Subset
  • Functions of Other T Cell Subsets
  • Summary
  • Suggested Readings
  • 11 Differentiation and Functions of CD8+ Effector T Cells
  • Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes
  • Effector Functions of CD8+ Cytotoxic T Lymphocytes
  • Roles of CD8+ CTLs in Host Defense
  • Summary
  • Selected Readings
  • 12 B Cell Activation and Antibody Production
  • Overview of Humoral Immune Responses
  • Antigen Recognition and Antigen-Induced B Cell Activation
  • Helper T Cell-Dependent Antibody Responses to Protein Antigens
  • Antibody Responses to T-Independent Antigens
  • Antibody Feedback: Regulation of Humoral Immune Responses by Fc Receptors
  • Summary
  • Selected Readings
  • 13 Effector Mechanisms of Humoral Immunity
  • Overview of Humoral Immunity
  • Neutralization of Microbes and Microbial Toxins
  • Antibody-Mediated Opsonization and Phagocytosis
  • The Complement System
  • Neonatal Immunity
  • Summary
  • Selected Readings
  • 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
  • General Features of Immunity at Epithelial Barriers
  • Immunity in the Gastrointestinal System
  • Immunity in Other Mucosal Tissues
  • The Cutaneous Immune System
  • Immune-Privileged Tissues
  • Summary
  • Selected Readings
  • 15 Immunologic Tolerance and Autoimmunity
  • Overview of Immunologic Tolerance
  • T Lymphocyte Tolerance
  • B Lymphocyte Tolerance
  • Tolerance to Commensal Microbes and Other Foreign Antigens
  • Mechanisms of Autoimmunity
  • Summary
  • Selected Readings
  • 16 Immunity to Microbes
  • Overview of Immune Responses to Microbes
  • Immunity to Extracellular Bacteria
  • Immunity to Intracellular Bacteria
  • Immunity to Fungi
  • Immunity to Viruses
  • Immunity to Parasites
  • Strategies for Vaccine Development
  • Summary
  • Selected Readings
  • 17 Transplantation Immunology
  • General Principles of Transplantation Immunology
  • Adaptive Immune Responses to Allografts
  • Patterns and Mechanisms of Allograft Rejection
  • Prevention and Treatment of Allograft Rejection
  • Xenogeneic Transplantation
  • Blood Transfusion and the ABO and Rh Blood Group Antigens
  • Hematopoietic Stem Cell (HSC) Transplantation
  • Summary
  • Selected Readings
  • 18 Immunity to Tumors
  • Overview of Tumor Immunity
  • Tumor Antigens
  • Immune Responses to Tumors
  • Evasion of Immune Responses by Tumors
  • Immunotherapy for Tumors
  • Summary
  • Selected Readings
  • 19 Hypersensitivity Disorders
  • Causes of Hypersensitivity Diseases
  • Mechanisms and Classification of Hypersensitivity Reactions
  • Diseases Caused by Antibodies
  • Diseases Caused by T Lymphocytes
  • Therapeutic Approaches for Immunologic Diseases
  • Selected Immunologic Diseases: Pathogenesis and Therapeutic Strategies
  • Summary
  • Selected Readings
  • 20 Allergy
  • Overview of IgE-Dependent Allergic Reactions
  • Production of IgE
  • Cells Involved in Allergic Reactions
  • IgE- and Mast Cell–Dependent Reactions
  • Genetic Susceptibility to Allergic Disease
  • Allergic Diseases in Humans: Pathogenesis and Therapy
  • The Protective Roles of IgE- and Mast Cell–Mediated Immune Reactions
  • Summary
  • Selected Readings
  • 21 Congenital and Acquired Immunodeficiencies
  • Overview of Immunodeficiency Diseases
  • Primary (Congenital) Immunodeficiencies
  • Secondary (Acquired) Immunodeficiencies
  • Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome
  • Summary
  • Selected Readings
  • Glossary
  • Appendices
  • Appendix I Cytokines
  • Appendix II Principal Features of Selected CD Molecules
  • Appendix III Laboratory Techniques Commonly Used in Immunology
  • Laboratory Methods Using Antibodies
  • Transgenic Mice and Gene Targeting
  • Methods for Studying T Lymphocyte Responses
  • Methods for Studying B Lymphocyte Responses
  • Clinical Diagnostic Applications of Immunologic Assays
  • Index

Product details

  • No. of pages: 608
  • Language: English
  • Copyright: © Elsevier 2017
  • Published: December 26, 2016
  • Imprint: Elsevier
  • eBook ISBN: 9780323523233
  • Paperback ISBN: 9780323479783

About the Authors

Abul Abbas

Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Affiliations and Expertise

Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Andrew Lichtman

Affiliations and Expertise

Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Shiv Pillai

Affiliations and Expertise

Massachusetts General Hospital Cancer Center, Boston, MA, USA

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