Cellular and Animal Models in Human Genomics Research - 1st Edition - ISBN: 9780128165737

Cellular and Animal Models in Human Genomics Research

1st Edition

Series Volume Editors: Katherina Walz Juan I. Young
Paperback ISBN: 9780128165737
Imprint: Academic Press
Published Date: 1st September 2019
Page Count: 312
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

1. Introduction to human genetics
2. Disease in a dish: Cellular models to understand human conditions
3. Tiny models to answer big questions: The worm and the yeast as tools in human genetics research
4. Understanding human genetic disease with the fly
5. Studying human genetic variation in zebrafish
6. The mouse, a model organism for biomedical research
7. CRISPR-Cas technology as a tool to create animal models for biomedical research
8. Integrative modeling and novel technologies in human genomics
9. Models to understand human genomics, final considerations


Description

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals.

Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth.

Key Features

  • Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies
  • Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health
  • Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Readership

Active researchers, basic and translational scientists, clinicians, postgraduates, and students in the areas of genetics, human genomics, pathology, cellular biology, organismal biology, molecular biology, biochemistry, and bioinformatics


Details

No. of pages:
312
Language:
English
Copyright:
© Academic Press 2020
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128165737

Ratings and Reviews


About the Series Volume Editors

Katherina Walz Series Volume Editor

Katherina Walz, Ph.D., Director for the Division for Models of Human Disease at the John P. Hussman Institute for Human Genomics, is a biologist interested in the molecular basis of human genetic conditions, with special emphasis in those that are related to brain function and altered behavioral outcomes. Her research is focused in the validation of the genetic cause, the definition of the phenotypic outcomes, and the elucidation of the molecular and physiological pathways related to human diseases. Dr. Walz is also an Research Associate Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics, at the University of Miami Health System, University of Miami, Florida.

Affiliations and Expertise

Research Associate Professor, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Health System, University of Miami, Miami, FL, USA

Juan I. Young Series Volume Editor

Juan I. Young, Ph.D., is an Associate Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics and Co-Director of the Center for Molecular Genetics at the John P. Hussman Institute for Human Genomics, University of Miami Health System, University of Miami, Florida. Young is a neurobiologist interested in identifying epigenetic signatures of human genetic diseases and in establishing animal models of neurological diseases. He has a longstanding interest in neurodevelopmental disorders in general and in understanding the pathogenesis of Rett Syndrome. His work includes the identification of RNA-related functions of MeCP2, mutated in Rett Syndrome and the characterization of cellular and mouse models for this disease.

Affiliations and Expertise

Research Associate Professor, Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami Health System, University of Miami, Miami, FL, USA