Cell Surface Proteases

Cell Surface Proteases

1st Edition - April 2, 2003

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  • Editor: Wen-Tien Chen
  • eBook ISBN: 9780080490885

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Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource.

Key Features

* Provides an overview of the entire field of cell surface proteases in a single volume
* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine
* A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage


Developmental biologists, cell biologists, genetics researchers, and molecular biologists.

Table of Contents

  • Membrane Type - Matrix Metalloproteinases
    Surface Association of Secreted Matrix Metalloproteinases
    Biochemical Properties and Functions of Membrane-anchored Metalloprotease-Disintegrin Proteins (ADAMs)
    Shedding of plasma membrane proteins
    Expression of Meprins in Health and Disease
    Type II Transmembrane Serine Proteases
    DPPIV, Seprase and Related Serine Peptidases in Multiple Cellular Functions
    The Secretases of Alzheimer's Disease
    Plasminogen Activation at the Cell Surface
    Cell Surface Cathepsin B: Understanding its Functional Significance
    Protease activated receptors
    EMMPRIN (CD147), a cell surface regulator of Matrix Metalloproteinase Production and Function
    The evolving roles of Cell Surface Proteases in Health and Disease: Implications for Developmental, Adaptive, Inflammatory and Neoplastic Processes
    Shed Membrane Vesicles and Clustering of Membrane-bound Proteolytic Enzymes

Product details

  • No. of pages: 452
  • Language: English
  • Copyright: © Academic Press 2003
  • Published: April 2, 2003
  • Imprint: Academic Press
  • eBook ISBN: 9780080490885

About the Series Volume Editor

Wen-Tien Chen

Affiliations and Expertise

State University of New York at Stony Brooks, New York, U.S.A.

About the Serial Volume Editor

Stanley Zucker

Affiliations and Expertise

VA Medical Center, Northport, New York, U.S.A.

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