Cell Surface GRP78, a New Paradigm in Signal Transduction Biology - 1st Edition - ISBN: 9780128123515

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

1st Edition

Editors: Salvatore V. Pizzo
Paperback ISBN: 9780128123515
Imprint: Academic Press
Published Date: 1st March 2018
Page Count: 150
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.

Key Features

  • Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies
  • Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease
  • Provides four-color illustrations that facilitate the narrative

Readership

Cell biology researchers, teachers and graduate students specializing in the areas of medical oncology, lipidology, pharmacology and drug development, protein chemistry/biochemistry, infectious diseases, neurology and hematology. The book may be of interest also to members of pharmaceutical companies

Table of Contents

1. Introduction to the Discovery of the Endoplasmic Reticulum Chaperone GRP78 on the Cell Surface
2. The Endoplasmic Reticulum Chaperone GRP78 also Functions as a Cell Surface Signaling Receptor
3. Cell surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in Cancer
4. Cell Surface GRP78: A Targetable Marker of Cancer Stem-like Cells
5. Cell Surface GRP78 Regulates the Pro-Coagulant Activity of Tissue Factor
6. GRP78 Modulates the Plasminogen Activating System in the Brain: Implications for Human Disease
7. Escherichia coli Subtilase Cleaves Cell Surface GRP78 preventing COOH-terminal Signaling

Details

No. of pages:
150
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128123515

About the Editor

Salvatore V. Pizzo

Studies from Pizzo’s laboratory identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies. Cell surface GRP78 functions as a signaling receptor promoting tumor proliferation and suppressing apoptosis. Patients with a number of malignancies mount an autoimmune response to GRP78 and these antibodies, which bind to the NH2 terminal domains of GRP78, are receptor agonists whose appearance is a marker of poor prognosis. More recently, his lab has shown that antibodies directed against the COOH-terminal domain of GRP78 are receptor antagonists which may have therapeutic potential for treating patients whose tumors express GRP78 on the cell surface.

Affiliations and Expertise

Distinguished Professor, Department of Pathology, Duke University Medical Center, Durham, NC, USA

Ratings and Reviews