In the past approximately quarter of a century, science has made significant progress in elucidating the skeletal elements of the cell, the extracellular matrix, cytoskeleton and nuclear matrix (i.e. the tissue matrix). While we currently know a great deal about some of the elements that comprise these structural systems, we still do not fully understand cellular structures and their relationship to cellular function. The cell is a highly ordered machine in which the skeleton provides the framework on which cellular functions take place. It is now becoming apparent that what were typically considered "soluble reactions" are rare, if existent at all. The structural systems contribute more to the cell than a framework for shape, although this is an important function. Cellular shape is reflecting what a cell is, does and will be. One can not inextricably separate cell structure and function, they go hand-in-hand.
Numerous laboratories have contributed to our current understanding of the role of cell structure in cell signaling and we are now at an exciting time in this field. This volume summerizes where investigations into the role of the tissue matrix system in cellular signaling have come and to propose new directions that this research will take in the next several years. This is not meant to be complete, but hopefully will provide the reader with an overview on our current understanding of this field.
Contents. List of Contributors. Preface (R.H. Getzenberg). Extracellular Matrix and Nuclear Matrix Interactions may Regulate Apoptosis and Tissue-Specific Gene Expression: A Concept whose Time has come. (S. Lelievre, V.M. Weaver, C.A. Lavabell, and M.J. Bissel). Role of the Extracellular Matrix and Cytoskeleton in the Regulation of Cyclins, Cyclin-Dependent Kinase Inhibitors, and Anchorage-Dependent Growth (R.K. Assoian, X. Zhu, G.E. Davey, and M.E. Bottazzi). Aptamer Adaptability: Utilizing Tumor Cell Surface Heterogeneity to Self-Select Appropriate Diagnostic and Therapeutic Agents (M.G. Schurmann and D.S. Coffey). Cytoskeleton-Mediated Aspects of Signal Transduction (R.M. Holmes, M.J. Carabatsos, and D.F. Albertini). The Role of the Cytoskeleton in Adhesion-Mediated Signaling and Gene Expression (a. BenZe'ev and A.D. Bershadsky). Subnuclear Trafficking of Steroid Receptors (D.B. DeFranco, J. Liu, Y. Tang, and J. Yang). The Role of Nuclear Matrix in Tissue-Specific Gene Expression (M.J. Horton and R.H. Getzenberg). Explaining Aberrations of Cell Structure and Cell Signaling in Cancer Using Complex Adaptive Systems (E.D. Schwab and K.J. Pienta). Index.
- © Elsevier Science 1997
- 19th October 1997
- Elsevier Science
- eBook ISBN:
- Hardcover ISBN:
Departments of Pathology, Surgery, Medicine and Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
@from:Denys Wheatley @qu:Book Review
Cell Structure and Signalling
Edited by R.H. Getzenberg
The following several chapters reveal one of the interesting things about this collection of papers drawn together by Bob Getzenberg, which is refreshingly different approaches taken by various authors in relation to the overall theme, although Schurmann and Coffey do least to place their article in direct alignment with the idea of the relationship between cell structure and signalling. Ben-Ze'ev and Bershadsky have produced an exceptionally good and very clear exposition of adhesion-mediated signalling, which is one of the main strengths of this volume, making it a very useful book to have at hand in this increasingly studied field. @source:Cell Biology International