Cell Signaling Pathways in Development

1st Edition, Volume 149 - May 18, 2022
Editor: Philippe M. Soriano
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 0 9 7 - 7
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 0 9 8 - 4

Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting in… Read more

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Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Ephrin signaling, Cell signaling to the extracellular matrix, Signaling by TGF-b superfamily members, Hedgehog signaling, Parallels in signaling during development and regeneration, Hippo signaling, Wnt/PCP signaling, Signaling oscillations in presomitic mesoderm, FGFs/RTKs subcellular signaling compartments, and Signaling dynamics.

Cover image
Table of Contents
Title Page
Copyright
Contributors
Preface
Chapter One: Hedgehog signaling
Abstract
1: Introduction
2: The developmental genetics of Hh signaling in Drosophila
3: The developmental genetics of Hh signaling in vertebrates
4: Multiple protein interactions mediate reception of the Hh signal
5: Structure and biosynthesis of Hh proteins
6: Release and movement of Hh proteins from producing cells
7: Reception of HH at the membrane: the role of Patched and Smoothened
8: The intracellular response to Hh
9: Concluding comments
Acknowledgments
References
Chapter Two: Different strategies by distinct Wnt-signaling pathways in activating a nuclear transcriptional response
Abstract
1: Overview of Wnt-signaling pathways
2: Induction of nuclear responses downstream of Wnt-signaling
3: How does β-catenin get transported into the nucleus
4: Concluding remarks
Acknowledgments
References
Chapter Three: Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis
Abstract
1: Introduction
2: Components of the Hippo pathway and their regulation
3: The contribution of resident CFs to cardiac fibrosis
4: Outstanding questions and future directions
5: Conclusion
Acknowledgments
References
Chapter Four: Pulling back the curtain: The hidden functions of receptor tyrosine kinases in development
Abstract
1: Introduction
2: Receptor tyrosine kinase signaling
3: Dismantling RTK signaling one pathway at a time
4: Without canonical signaling, what novel functions are revealed?
5: Conclusion
Acknowledgments
References
Chapter Five: Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development
Abstract
1: Introduction
2: EPH/EPHRIN function through an evolutionary lens
3: Cellular mechanisms underlying EPH/EPHRIN-mediated cell sorting and boundary formation
4: Nervous system development
5: Craniofacial and musculoskeletal development
6: Conclusions and perspectives
Acknowledgments
References
Chapter Six: Integrins, anchors and signal transducers of hematopoietic stem cells during development and in adulthood
Abstract
1: Integrins
2: A common origin of vascular and hematopoietic cells
3: Involvement of integrins in the establishment of the hematopoietic system
4: Contribution of integrin-mediated adhesion to life-long hematopoiesis
5: Integrin-mediated mechanosensing in the HSPC niche
6: Integrin-mediated support of leukemic stem cells
7: Conclusions
Acknowledgments
References
Chapter Seven: Putting in the Erk: Growth factor signaling and mesoderm morphogenesis
Abstract
1: Introduction
2: The fates of vertebrate mesodermal populations marked by brachyury
3: FGF expression in the mesoderm: An upstream cue for Erk-dependent gene induction
4: Generation and interpretation of transient Erk signaling in vertebrate mesoderm
5: The role of Erk signaling in initiating and sustaining brachyury expression
6: A role for Erk and a brachyury homology in Drosophila mesoderm specification
7: Moving mesoderm: Erk-dependent control of convergence and extension
8: Erk regulation of epithelial-to-mesenchymal transition in the primitive streak
9: A potential role for Erk signaling in mesodermal directed cell migration
10: Open questions and new tools for Erk control over mesoderm specification and movement
Acknowledgments
References
Chapter Eight: Establishment and interpretation of NODAL and BMP signaling gradients in early vertebrate development
Abstract
1: Introduction
2: NODAL signaling
3: BMP signaling
4: Interactions between NODAL and BMP signaling
5: Outlook
Acknowledgments
References
Chapter Nine: Signaling oscillations in embryonic development
Abstract
1: Introduction
2: Single-cell oscillation dynamics
3: Tissue-wide oscillation dynamics
4: Perspective
Acknowledgments
References
Chapter Ten: Parallels in signaling between development and regeneration in ectodermal organs
Abstract
1: Introduction
2: From signaling centers during development to stem cell regulated morphogenesis in the adult
3: Shh
4: Wnt
5: Notch
6: Yap/Taz
7: Conclusion—The regenerative properties of the ectoderm
Acknowledgments
References

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Philippe M. Soriano