Cell Shape - 1st Edition - ISBN: 9780126646559, 9780323149990

Cell Shape

1st Edition

Determinants, Regulation, And Regulatory Role

Editors: Felix Bronner
eBook ISBN: 9780323149990
Imprint: Academic Press
Published Date: 28th June 1989
Page Count: 448
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Cell Shape: Determinants, Regulation, and Regulatory Role is written to help readers understand cell shape and its regulation. It provides insight into how the shape of a cell is determined at a molecular level. It also discusses how the shape of the cell, as a signal, controls gene expression and modulates intercellular interaction. Divided into four parts encompassing 13 chapters, this volume begins with an overview of the mechanism of shape determination. It then explores how the cytoskeleton, the extracellular matrix, and biochemical force transduction may affect or respond to cell shape control. Other chapters focus on the mechanical modeling of cell shape and the biochemical reactions underlying cell motility. The text also describes the results of the molecular studies that have provided important information on the composition of the cytoskeleton. The final chapter reviews the shape changes that happen during embryogenesis. It also considers how the polarity of the embryo is determined. This book is a valuable resource for biologists, embryologists, and cell biologists.

Table of Contents


I. Basic Determinants of Cell Shape

1. Tension and Compression as Basic Determinants of Cell Form and Function: Utilization of a Cellular Tensegrity Mechanism

I. Introduction

II. Cell Shape and Regulation of Cell Function

III. Determinants of Cell Shape

IV. Modeling Cell Behavior with Tensegrity Cell Models

V. How Physical Forces Provide Regulatory Information

VI. Conclusion


2. Cell Motility and Tissue Morphogenesis

I. Introduction

II. Cell Motility: Forces in the Leading Lamella

III. Mechanical Aspects of Morphogenesis

IV. Discussion


3. Ion Channels as Mechanical Transducers

I. Introduction

II. Stretch-Activated Ion Channels

III. Nonspecific Mechanosensors and Stretch-Activated Channels

IV. Evolution of Stretch-Activated Channels

V. Stretch-Activated Channels in Cell Size Regulation: A Speculation


II. Molecular Approaches to Cell Shape

4. Cell Shape and Cell Contacts: Molecular Approaches to Cytoskeleton Expression

I. Introduction

II. Cell Shape-Related Regulation of Cytoskeletal Protein Expression

III. Regulation of Cytoskeleton Organization and Expression during Differentiation

IV. Concluding Remarks


5. Fibronectin as a Transducer of Tension

I. Introduction

II. Structure and Properties of Fibronectin

III. Fibronectin Receptors

IV. Cytoskeleton Interactions

V. Fibronectin: Cell Adhesion, Shape, and Motility


6. Extracellular Matrix Interaction with the Cytoskeleton

I. Introduction

II. Cell Shape, Cytoskeleton, and Gene Expression

III. Regulation of Levels of Gene Expression by the Cytoskeleton

IV. Mechanisms of Cytochalasin Action

V. Interaction of the Extracellular Matrix with Actin via Cell Surface Receptors

VI. Concluding Remarks


7. Cell Shape and Growth Control: Role of Cytoskeleton-Extracellular Matrix Interactions

I. Introduction

II. Growth Factors and the Cell Cycle

III. Cell Adhesion and Growth Control

IV. Importance of Cell-Extracellular Matrix Interactions

V. Role of the Cytoskeleton


III. Shaping in Specialized Cells

8. Red Cell Shape

I. Introduction

II. Red Cell Morphology

III. Red Cell Volume

IV. The Red Cell Membrane

V. The Red Cell Membrane Skeleton

VI. Membrane Mechanics

VII. Bilayer Couple Effects

VIII. Membrane Elasticity

IX. Membrane Plasticity

X. Red Cell Deformability

XI. Membrane Durability

XII. Evolution of Red Cell Shape

XIII. Speculations on the Genesis of Red Cell Shape


9. Nerve Cell Shape

I. Introduction

II. Neuronal Morphology and Maintenance

III. Chemical Properties of Cytoskeletal Components

IV. Formation of Neuronal Processes

V. Changes of Mature Neuronal Shape

VI. Summary


10. Effect of Cell Shape on Cartilage Differentiation

I. Introduction

II. Effects of Cell Shape on Chondrogenic Differentiation

III. Effects of Cell Shape on Continued Expression of the Cartilage Phenotype

IV. Speculations: Mechanisms of Shape or of Cytoskeletal Influences on Differentiation

V. Concluding Remarks


11. Bone Cell Shape and Function

I. Bone Cell Shape, Motility, and Function

II. Response of Bone, Bone Cells, and Cytoplasm to Mechanical Perturbations

III. Summary


IV. The Shape of Organisms

12. Unicellular Morphogenesis

I. Introduction

II. Morphogenesis in Protozoa

III. Morphogenesis in Unicellular Algae

IV. Conclusions


13. Cell Shape and Vertebrate Embryogenesis

I. Introduction

II. Embryonic Polarity

III. Gastrulation and Notochord Formation

IV. Neurulation

V. Conclusions




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© Academic Press 1989
Academic Press
eBook ISBN:

About the Editor

Felix Bronner

Affiliations and Expertise

Department of Oral Biology, University of Connecticut Health Center

Ratings and Reviews