Description

Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including:

  • Safety and efficacy of stem cell treatments
  • Stem-cell-based organ regeneration
  • Integrating stem cells into personalized drug discovery
  • Using pluripotent stem cells for treating neurological disease
  • Engineering hematopoietic stem cells for innovative therapies

Contributions come from leading voices in the field, including:
- Shinya Yamanaka, Recipient of the 2012 Nobel Prize for Physiology or Medicine, Recipient of the 2012 Millennium Technology Prize, Professor and Director of the Center for iPS Cell Research and Application at Kyoto University, Senior Investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology and Professor at the University of California, San Francisco
- George Q. Daley, Samuel E. Lux IV Professor of Hematology/Oncology at Harvard Medical School and Director for the Stem Cell Transplantation Program at Boston Children’s Hospital
- Irving Weissman, Member of National Academy of Sciences, Virgina & D.K Ludwig Professor for Clinical Investigation in Cancer Research, and Director for Institute of Stem Cell Biology and Regenerative Medicine at Stanford University of Medicine

Cell Press Reviews: Stem Cells to Model and Treat Disease is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

Key Features

  • Provides timely overviews on a wide range of stem cell applications
  • Offers insight from experts on the key opportunities and challenges facing the field
  • Features reviews on genetic, cellular, and molecular aspects of stem-cell-based applications
  • Includes articles originally published in Cell, Cell Stem Cell, Neuron, Trends in Molecular Medicine, and Trends in Biotechnology

Readership

Academic and medical researchers, clinicians and students in stem cell biology, regenerative medicine, bioengineering, tissue engineering, molecular biology, evolutionary and developmental biology and individuals interested in or working in stem cell policy

Table of Contents

About Cell Press

Contributors

Preface

Chapter 1. Stem Cell Therapies Could Change Medicine… If They Get the Chance

Summary

Introduction

Doing Harm

The Therapeutic Entity is the Stem Cell Itself

In Vivo Veritas

An Unexpected but Potent Barrier: Business Development

In Closing....

References

Chapter 2. Why Is It Taking So Long to Develop Clinically Competitive Stem Cell Therapies for CNS Disorders?

Summary

Introduction

The Problem of Generating the Right Cells and Understanding Their Mechanisms of Action

The Problem of Using the Right Animal Model and Behavioral Tests

The Problem of Distribution and Progression of Pathology

The Problem of Translating Basic Research Findings to Patients

The Problem of Competing Therapeutic Approaches

The Problem of Costs

Conclusions

References

Chapter 3. Assessing the Safety of Stem Cell Therapeutics

Acknowledgments

Summary

Introduction

Current Status of Stem Cell Therapeutics and the Safety Challenge

The Safety Issues: Preclinical Assessment

The Safety Issues: Clinical Assessment

Current Assays for Stem Cell Therapy Safety Assessment

Regulation of Stem Cell Therapeutics

Proposals

References

Chapter 4. The Promise and Perils of Stem Cell Therapeutics

Acknowledgments

Summary

Cell Therapeutics: The Current Standard of Care

Lessons from the Historical Development of HSC Transplantation

Stem Cell Therapeutics: Frontline Clinical Trials and Medical Innovations

Conclusions

References

Chapter 5. Reprogramming Cellular Identity for Regenerative Medicine

Acknowledgments

Summary

Introduction

Manipulating Cellular Identity In Vitro

Reprogramming-Based Disease Models Pr

Details

No. of pages:
374
Language:
English
Copyright:
© 2014
Published:
Imprint:
AP Cell
Print ISBN:
9780124201910
Electronic ISBN:
9780127999166