Cell Press Reviews: Stem Cells to Model and Treat Disease

Cell Press Reviews: Stem Cells to Model and Treat Disease

1st Edition - December 3, 2013

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  • Editor: Cell Press
  • eBook ISBN: 9780127999166
  • Paperback ISBN: 9780124201910

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Description

Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including: Safety and efficacy of stem cell treatments Stem-cell-based organ regeneration Integrating stem cells into personalized drug discovery Using pluripotent stem cells for treating neurological disease Engineering hematopoietic stem cells for innovative therapies Contributions come from leading voices in the field, including:- Shinya Yamanaka, Recipient of the 2012 Nobel Prize for Physiology or Medicine, Recipient of the 2012 Millennium Technology Prize, Professor and Director of the Center for iPS Cell Research and Application at Kyoto University, Senior Investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology and Professor at the University of California, San Francisco- George Q. Daley, Samuel E. Lux IV Professor of Hematology/Oncology at Harvard Medical School and Director for the Stem Cell Transplantation Program at Boston Children’s Hospital- Irving Weissman, Member of National Academy of Sciences, Virgina & D.K Ludwig Professor for Clinical Investigation in Cancer Research, and Director for Institute of Stem Cell Biology and Regenerative Medicine at Stanford University of Medicine Cell Press Reviews: Stem Cells to Model and Treat Disease is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

Key Features

  • Provides timely overviews on a wide range of stem cell applications
  • Offers insight from experts on the key opportunities and challenges facing the field
  • Features reviews on genetic, cellular, and molecular aspects of stem-cell-based applications
  • Includes articles originally published in Cell, Cell Stem Cell, Neuron, Trends in Molecular Medicine, and Trends in Biotechnology

Readership

Academic and medical researchers, clinicians and students in stem cell biology, regenerative medicine, bioengineering, tissue engineering, molecular biology, evolutionary and developmental biology and individuals interested in or working in stem cell policy

Table of Contents

  • About Cell Press

    Contributors

    Preface

    Chapter 1. Stem Cell Therapies Could Change Medicine… If They Get the Chance

    Summary

    Introduction

    Doing Harm

    The Therapeutic Entity is the Stem Cell Itself

    In Vivo Veritas

    An Unexpected but Potent Barrier: Business Development

    In Closing....

    References

    Chapter 2. Why Is It Taking So Long to Develop Clinically Competitive Stem Cell Therapies for CNS Disorders?

    Summary

    Introduction

    The Problem of Generating the Right Cells and Understanding Their Mechanisms of Action

    The Problem of Using the Right Animal Model and Behavioral Tests

    The Problem of Distribution and Progression of Pathology

    The Problem of Translating Basic Research Findings to Patients

    The Problem of Competing Therapeutic Approaches

    The Problem of Costs

    Conclusions

    References

    Chapter 3. Assessing the Safety of Stem Cell Therapeutics

    Acknowledgments

    Summary

    Introduction

    Current Status of Stem Cell Therapeutics and the Safety Challenge

    The Safety Issues: Preclinical Assessment

    The Safety Issues: Clinical Assessment

    Current Assays for Stem Cell Therapy Safety Assessment

    Regulation of Stem Cell Therapeutics

    Proposals

    References

    Chapter 4. The Promise and Perils of Stem Cell Therapeutics

    Acknowledgments

    Summary

    Cell Therapeutics: The Current Standard of Care

    Lessons from the Historical Development of HSC Transplantation

    Stem Cell Therapeutics: Frontline Clinical Trials and Medical Innovations

    Conclusions

    References

    Chapter 5. Reprogramming Cellular Identity for Regenerative Medicine

    Acknowledgments

    Summary

    Introduction

    Manipulating Cellular Identity In Vitro

    Reprogramming-Based Disease Models Provide a New Platform for Disease Research

    Reprogramming Imperfectly Resets the Epigenome to an ES Cell-Like State

    Sources of Epigenetic Variation In Vivo: Environment and Stochasticity

    Genetic, Environmental, and Epigenetic Contributions to Complex Diseases

    Value of Stem Cell-Based Disease Modeling

    Conclusions

    References

    Chapter 6. Cardiac Stem Cell Therapy and the Promise of Heart Regeneration

    Acknowledgments

    Summary

    Introduction

    Established Principles

    Unresolved Questions

    Conclusions

    References

    Chapter 7. Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

    Summary

    Introduction: Key Roles for Noncentralized Patterning Mechanisms in Organogenesis

    Self-Organization of Neuroectodermal Structures

    Endodermal Tissues

    Control of Epithelial-Mesenchymal Interactions

    Perspectives for Future Medical Applications

    References

    Chapter 8. Induced Pluripotent Stem Cells: Past, Present, and Future

    Acknowledgments

    Summary

    Introduction

    The Merging of Three Scientific Streams Led to the Production of iPSCs

    Maturation and Understanding of iPSC Technology

    New Scientific Streams have Emerged from iPSC Technology

    The Big Question: are iPSCs Different from ESCs?

    Is there a “Dark Side” to Induced Pluripotency?

    Why are ESCs and iPSCs So Remarkably Similar?

    Concluding Thoughts

    References

    Chapter 9. Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders

    Acknowledgments

    Summary

    Introduction

    Cell-Fate Plasticity and iPSC Reprogramming

    Directed Reprogramming: A Shortcut

    Cell Reprogramming-Based Models of Adult Neurological Disorders

    AD: Cell-Type-Specific In Vitro Correlates of Human Brain Pathology

    PD and the Role of Environmental Stressors

    ALS and Nonautonomous Mechanisms of Disease

    Therapeutics: the Endgame

    Epigenetic Reprogramming and the Etiology of Neurological Disorders: Nature Versus Nurture

    Conclusion

    References

    Chapter 10. Therapeutic Translation of iPSCs for Treating Neurological Disease

    Summary

    Introduction

    Modeling Neurological and Psychiatric Diseases In Vitro with Pluripotent Stem Cells

    Translational and Clinical Opportunities for Pluripotent Stem Cells

    Conclusion/Future Directions

    References

    Chapter 11. Modeling Human Disease with Pluripotent Stem Cells: From Genome Association to Function

    Acknowledgments

    Summary

    Resolving the Taxonomy of Human Disease

    hPSCs as a Powerful Tool for Modeling Human Disease

    Challenges and Approaches to Disease Modeling with hPSCs

    Illuminating Disease Mechanisms with hPSC-Based Disease-Modeling Data

    Identification of Shared Molecular Disease Mechanisms between Disease Subtypes

    hPSCs as a Tool to Sort and Curate Genomics Data

    Modeling Non-Cell-Autonomous Contributions to Human Disease with hPSCs

    Concluding Remarks

    References

    Chapter 12. How Can Human Pluripotent Stem Cells Help Decipher and Cure Huntington’s Disease?

    Summary

    Introduction

    PSC-Based Therapy for HD

    Human PSCs for Gene Therapy Validations

    Exploring Molecular Mechanisms of HD Using Human PSC Lines

    So, What can PSC Neural Derivatives Tell Us about HD?

    Using Human PSC Lines for Drug Discovery in HD

    Conclusion

    References

    Chapter 13. Integrating Human Pluripotent Stem Cells into Drug Development

    Acknowledgments

    Summary

    Introduction

    Shifting Paradigms in Drug Discovery

    Building More Physiologically Relevant In Vitro Assays

    IVD hPSC-Derived Cells for Drug Discovery

    Challenges to Implementing IVD hPSC-Derived Cell Models in Drug Discovery

    Introduction of New Technology

    Licensing, Intellectual Property, and Legal Issues

    Cell-Based Issues

    Assay-Based Issues

    Future Use of IVD hPSC-Derived Cells in Drug Discovery

    References

    Chapter 14. Process Engineering of Human Pluripotent Stem Cells for Clinical Application

    Acknowledgments

    Summary

    The Potential for hPSC-Based Therapies

    Transferring hPSCs to the Clinic: Crucial Needs in Process Engineering

    Process Engineering of hPSCs

    Final Remarks and Future Perspectives

    References

    Chapter 15. Mesenchymal Stem Cells: Therapeutic Outlook for Stroke

    Summary

    Current Therapies for Stroke

    Bone Marrow-Derived Mesenchymal Stem Cells (MSCs)

    MSC Transplantation in Experimental Stroke Models

    Clinical Studies on Intravenously Delivered Human MSCs

    Concluding Remarks and Future Prospects

    References

    Chapter 16. The Potential of Stem Cells as an In Vitro Source of Red Blood Cells for Transfusion

    Summary

    Unmet Transfusion Needs

    The Search for the Optimal Stem Cell Source

    Economic and Logistical Challenges

    Intermediate Therapeutic Goals

    Safety Concerns

    Concluding Remarks

    Web Resources

    References

    Chapter 17. Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease

    Acknowledgments

    Summary

    Background

    Identification and Expansion of HSCS

    Introduction of De Novo Gene Functions into HSCs

    Selection of Gene Functions to Confer Resistance to HIV

    In Vivo Engraftment of Transduced HSCs

    Pretransplant Conditioning Regimens

    Design of HSC-Based Gene Therapy Clinical Trials in Humans

    Concluding Remarks

    References

    Chapter 18. Stem Cells in Translation

    iPSCs in Clinics

    Transplantation

    Brain in a Dish

    Cardiac Transdifferentiation

    Stem Cell and Diabetes

    Cancer Stem Cells

    Secrets in the Egg

    Power of Tissue Culture

    Challenges Ahead

    Index

Product details

  • No. of pages: 374
  • Language: English
  • Copyright: © AP Cell 2013
  • Published: December 3, 2013
  • Imprint: AP Cell
  • eBook ISBN: 9780127999166
  • Paperback ISBN: 9780124201910

About the Editor

Cell Press

Affiliations and Expertise

Cell, Cell Stem Cell, Trends in Molecular Medicine, Neuron, Trends in Biotechnology

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