Cell Press Reviews: Core Concepts in Cell Biology - 1st Edition - ISBN: 9780124201934, 9780127999180

Cell Press Reviews: Core Concepts in Cell Biology

1st Edition

Paperback ISBN: 9780124201934
eBook ISBN: 9780127999180
Imprint: AP Cell
Published Date: 9th December 2013
Page Count: 484
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Table of Contents

About Cell Press

Contributors

Preface

Chapter 1. The Cell Biology of Genomes: Bringing the Double Helix to Life

Acknowledgments

Summary

Introduction

The Stochastic Genome

Epigenetics—and When Epigenetics is not Epigenetics

Genome Organization as a Modulator of Genome Function

Facing the Complexity

References

Chapter 2. Condensin, Chromatin Crossbarring and Chromosome Condensation

Acknowledgements

Summary

Introduction

Molecular Architecture of Condensin

Differential Contributions of Condensin I and II to Chromosome Structure

Cell-Cycle Regulation of Chromosome Condensation

Towards a Mechanistic Understanding of Chromosome Condensation

A Model for Mitotic Chromosome Condensation

References

Chapter 3. Nuclear Positioning

Acknowledgments

Summary

Introduction

The Nuclear Positioning Toolbox

Initiation of Nuclear Movement

Characteristics of Nuclear Movements

MT-Mediated Nuclear Movement

Actin-Mediated Nuclear Movement

Nuclear Positioning and Disease

Cellular Significance of Nuclear Positioning: Hypotheses and Perspectives

Conclusions

References

Chapter 4. Evolution and Function of the Mitotic Checkpoint

Acknowledgments

Summary

Mitosis, Kinetochores, and the Mitotic Checkpoint

Evolution of the MC and its Auxiliary Proteins

The Inhibitor and its Target: MCC and Cdc20

Evolution, Function, and Regulation of Cdc20

Feedback Control of the MC: Ubiquitination of Cdc20 by the APC/C

Catalyzing MCC Production

The APC/C Pseudosubstrate Inhibitor within the MCC

The Fate of a Paralog: Evolution and Function of Bub1

Kinetochore Scaffolds for the Mitotic Checkpoint

Regulating the MCC: Essential and Conserved C


Description

Written by leading cell biologists and curated by Cell Press editors, reviews in the Cell Press Reviews: Core Concepts in Cell Biology publication informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field including:

  • Signaling mechanisms and membrane biology
  • Cytoskeletal self-organization and cell polarity
  • Organelle dynamics and biogenesis
  • Morphogenesis and cell motility
  • Chromatin and genome organization in nuclear function

Contributions come from leading voices in cell biology, who are defining the future of their field, including:
- Tom Misteli, National Cancer Institute
- Galit Lahav, Harvard Medical School
- Scott D. Emr, Cornell University
- David G. Drubin, University of California, Berkeley
- Tom Rapoport, Harvard Medical School
- Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden

This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

Key Features

  • Provides timely, comprehensive coverage across a broad range of cell biological topics
  • Offers foundational knowledge and expert insights to students and others new to the field
  • Features reviews from leaders in cell biology research and discussion of future directions for the field
  • Includes articles originally published in Cell, Current Biology, Developmental Cell, and Trends in Cell Biology

Readership

Academic, medical researchers and students across cell biology, molecular biology, developmental biology, stem cells


Details

No. of pages:
484
Language:
English
Copyright:
© AP Cell 2014
Published:
Imprint:
AP Cell
eBook ISBN:
9780127999180
Paperback ISBN:
9780124201934

Reviews

"…collates topical review articles recently published in Cell Press journals…informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field…" --Anticancer Research 34, 2014