Cell Polarity in Development and Disease

1st Edition, Volume 154 - April 25, 2023
Editor: Ulrich Tepass
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 1 5 8 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 1 6 5 - 7

Cell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapte… Read more

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Cell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cell polarity in the protist-to-animal transition, Polarized actin networks in development: Case studies from Drosophila, Protein clustering and cell polarization, Polarity in the Drosophila female germline, Context Matters: Mechanisms governing epithelial polarization in C. elegans, Epithelial polarity in the fly: Principles and diversity, Polarizing epithelial expulsion and expulsion driven by mispolarization, The Role of Apical-Basal Polarization in the Mammalian First Cell Fate Decision, and much more.

Cover image
Title page
Table of Contents
Current Topics in DEVELOPMENTAL BIOLOGY
Series page
Current Topics in DEVELOPMENTAL BIOLOGY
Copyright
Contributors
Preface
Chapter One: Cell polarity in the protist-to-animal transition
Abstract
1 Introduction
2 The apico-basal polarity of animal epithelial cells and its molecular control
3 The first polarized elements from the LECA: flagella, microtubules, basal bodies
4 Elements of the basal lamina and of focal adhesions in the amoebozoan/opisthokont (amorphean) ancestor
5 Obazoan and filozoan ancestors: origin of Cdc42 and Par6: coordinating polarity and actin polymerization
6 Filozoan ancestor: MAGUK proteins, cadherins, filopodial contacts, and the ancestry of cell-cell adhesions
7 Choanozoan ancestors and the origin of apical microvilli
8 Metazoan ancestors: origin of epithelial architecture and the explosion of polarity proteins
9 Conclusion
Acknowledgments
References
Chapter Two: Context matters: Lessons in epithelial polarity from the Caenorhabditis elegans intestine and other tissues
Abstract
1 Introduction to epithelia and C. elegans
2 Defining the C. elegans polarity network
3 The intestine
4 Variations on a theme: polarity lessons from other C. elegans epithelia
5 Conclusions and outlook
Acknowledgments
References
Chapter Three: Polarity and axis formation in the Drosophila female germ line
Abstract
1 Overview of oogenesis
2 Asymmetric stem cell division
3 Oocyte determination
4 Oocyte polarisation
5 The posterior positioning of the oocyte
6 The polarising signal
7 Polarising the anterior-posterior axis
8 Polarising the dorsal ventral-axis
9 Concluding remarks
Acknowledgements
References
Chapter Four: Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions
Abstract
1 Introduction
2 Supracellular contractile networks
3 Interactions of Arp2/3 networks and actomyosin networks
4 Concluding remarks
Acknowledgments
References
Chapter Five: Cell polarity and extrusion: How to polarize extrusion and extrude misspolarized cells
Abstract
1 Introduction
2 Cell extrusion, a polarized remodeling process
3 Polarity perturbations as a driving force for cell extrusion and death induction
4 Conclusions and perspectives
References
Chapter Six: The role of polarization and early heterogeneities in the mammalian first cell fate decision
Abstract
1 Introduction
2 Establishment of apical-basal polarity
3 Linking polarity and cell fate
4 The first cell fate decision beyond apical-basal polarity
5 Summary and discussion
Acknowledgments
References
Chapter Seven: Polarity in immune cells
Abstract
1 Introduction
2 Cell polarity and immune cell migration
3 Polarity at the immune synapse
4 Asymmetric cell division in lymphocytes
5 Conclusions and perspectives
References
Chapter Eight: Fat and Dachsous cadherins in mammalian development
Abstract
1 Introduction
2 Drosophila Fat and Dachsous
3 Mammalian Fat and Dachsous
4 Conclusions and remaining questions
References
Chapter Nine: Polarity in breast development and cancer
Abstract
1 Introduction
2 Models to study cell polarity in breast epithelia
3 Mammary gland development
4 Roles for apical-basal polarity proteins in breast cancer initiation and progression
5 Breast cancer treatment and resistance
6 Perspectives
References
Chapter Ten: Polarity in respiratory development, homeostasis and disease
Abstract
1 Introduction
2 Polarity and respiratory development
3 Polarity and lung homeostasis
4 Respiratory epithelial polarity and disease
5 Conclusions and outlook
Acknowledgments
References
Chapter Eleven: Polarity in skin development and cancer
Abstract
1 Introduction to epidermal cell types and architecture
2 Development of the epidermis
3 Polarity in the epidermis
4 Core polarity machinery
5 Mechanical polarity across the epidermis
6 Planar cell polarity in the epidermis
7 Polarity and skin cancer
8 Concluding remarks
References

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Ulrich Tepass