Cell Polarity in Development and Disease

Cell Polarity in Development and Disease

1st Edition - November 2, 2017

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  • Editor: Douglas Houston
  • Paperback ISBN: 9780128024386
  • eBook ISBN: 9780128125915

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Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research.

Key Features

  • Provides basic science understanding of cell polarity disease and development
  • Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer
  • Includes historical context of cell polarity research for potential future breakthroughs


Early researchers, professors, graduate students, and undergraduate students studying cell biology, developmental biology, genetics and across the biological and biomedical sciences

Table of Contents

  • 1. Overview of cell polarity: insights from model organisms and cellular systems
    2. Cell polarity in the egg and early embyro- mammal
    3. Pluripotency and cell polarity
    4. The role of cell polarity in adult stem cell maintenance
    5. Integration of cell polarity and growth factor signaling
    6. Cell polarity and the onset and progression of cancer
    7. Cell division and cell polarity
    8. Polarized membrane/vesicle trafficking and disease
    9. Polarized microtubule transport and disease
    10. Regulation of cell polarity in cell/neuronal migration
    11. Apical and planar cell polarity in ciliated epithelia
    12. Renal epithelial cell polarity and disease
    13. Hepatic cell polarity and disease
    14. Epidermal cell polarity and disease
    15. Cell polarity and sensory cell defects

Product details

  • No. of pages: 236
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: November 2, 2017
  • Imprint: Academic Press
  • Paperback ISBN: 9780128024386
  • eBook ISBN: 9780128125915

About the Editor

Douglas Houston

Douglas Houston is a Professor at the University of Iowa. His research is focused on a central problem in developmental biology: how a single-celled egg differentiates into an organism containing many different cell and tissue types. Using frog embryos as a model organism, he and his lab have isolated numerous novel genes with potential roles in key pathways of ovum functions, including genes involved in PGC formation, morphogenesis, and TGF-beta and Wnt growth factor signaling.

Affiliations and Expertise

Professor, Department of Biology, University of Iowa, IA, USA

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