Table of Contents


In Memoriam


Foreword to the First Edition

Foreword to the Second Edition

Foreword to the Third Edition

Foreword to the Fourth Edition


Section I Biophysical Chemistry, Metabolism, Second Messengers, and Ultrastructure

Chapter 1. Biophysical Chemistry of Physiological Solutions

I Summary

II Introduction

III Structure and Properties of Water

IV Interactions Between Water and Ions

V Protons in Solution

VI Interactions Between Ions

VII Solute Transport: Basic Definitions

VIII Measurement of Electrolytes and Membrane Potential

Appendix: Thermodynamics of Membrane Transport

AII Nernst Equilibrium


Chapter 2. Physiological Structure and Function of Proteins

I Summary

II Molecular Structure of Proteins

III Techniques for the Determination of the Structures of Proteins

IV Bulk Properties of Proteins: Proteins as Polyelectrolytes

V Relationship of Protein Structure to Function


Chapter 3. Cell Membranes

I Summary

II The Bimolecular Lipid Membrane

III Membrane Lipids and Proteins

IV The Fluid Mosaic Model of Cell Membranes


Chapter 4. Ionophores in Planar Lipid Bilayers

I Summary

II Ionophores

III Planar Lipid Bilayers

IV Ion Channel Properties in Planar Lipid Bilayers

V Gramicidin


Chapter 5. Cell Structure

I Introduction

II Techniques

III Cell Theory

IV The Plasma Membrane as the Basis of Cellularity

V Nucleus

VI Endoplasmic Reticulum

VII Golgi Apparatus

VIII Lysosomes

IX Mitochondria

X Cytoskeleton

XI Cell Junctions

XII Special Tissues, Specialized Ultrastructure



No. of pages:
© 2011
Academic Press
Print ISBN:
Electronic ISBN:

About the author

Edna Kaneshiro

Edna Kaneshiro is a distinguished research professor in the department of biology at the University of Cincinnati where she has been for 43 years. Dr. Kaneshiro’s research is on the lipids of eukaryote protists, including free living, parasitic, and opportunistic pathogens. Although work on a number of different protozoa is being performed, Kaneshiro’s current focus is on the AIDS-associated opportunistic infection caused by Pneumocystis carinii. This organism causes a type of pneumonia that can lead to the death of immunocompromised individuals. Pneumocystis proliferates extracellularly in the lung alveolus where lipids constitute a major part of lung surfactant. Thus, lipids are thought to be important to the nutrition, physiology and metabolism of the organism. The biosynthesis of pathogen-specific lipids represents potential targets for drug development. She also has an interest in the cell biology and life history of this poorly understood opportunistic infectious agent. Dr. Kaneshiro is an elected fellow of the American Association for the Advancement of Science and the American Academy of Microbiology


Reviews of previous edition:

"...a core textbook in cell physiology...The need for such a book is well justified and it fulfills its objectives admirably. It is especially strong on the subjects of signal transduction, membrane biology, ion channels, and neuronal and muscle cell physiology... It is a solid textbook in its field..."--DOODY'S PUBLISHING REVIEWS
"Cell Physiology Source Book 2e will be useful for advanced undergraduate and graduate students studying cell physiology, cell biophysics, electrophysiology, and biological scientists in many fields. The book is particularly suitable for introducing cell physiology to students with training in the physical sciences and for introducing cell biophysics to students with backgrounds in biology."--BIOPHYSICAL JOURNAL
"In his preface Sperelakis (emeritus, biophysics, U. of Cincinnati)describes himself as an 80-year-old retired professor living a quiet life when it came to his attention from multiple sources that his third edition text, published in 2001, had become quite rare and yet continued as the text of choice for many courses. At his request his editor surveyed instructors around the country for feedback, and their suggestions have been incorporated in this fourth edition. Chapters are more uniformly structured, the pitch is slightly lower to accommodate beginning graduate and senior-undergraduate students, and topics have been selected so as not to duplicate material readily available elsewhere. Material is arranged in sections on biophysical chemistry, metabolism, second messengers, and ultrastructure; membrane potential, transport physiology, pumps, and exchangers; membrane excitability and ion channels; synaptic transmission and sensory transduction; and muscle and other contractile systems. Academic Press is an imprint of Elsevier."--Reference and Research Book News, October 2012