Cell Physiology Source Book

Cell Physiology Source Book

Essentials of Membrane Biophysics

3rd Edition - August 2, 2001

Write a review

  • Editor: Nicholas Sperelakis
  • eBook ISBN: 9780080574554

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death.

Key Features

  • Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors
  • Includes broad coverage of both animal and plant cells
  • Appendixes review basics of the propagation of action potentials, electricity, and cable properties
  • Authored by leading experts in the field
  • Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics


Graduate students, postdoctoral fellows, and researchers in physiology, biophysics, cell biology, molecular biology, and biochemistry; upper-level undergraduates taking courses in cellular physiology

Table of Contents

  • Foreword to the First Edition

    Foreword to the Second Edition

    Foreword to the Third Edition

    Preface to the First Edition

    Preface to the Second Edition

    Preface to the Third Edition

    Section I Biophysical Chemistry, Metabolism, Second

    Messengers, and Ultrastructure

    1. Biophysical Chemistry of Physiological Solutions

    Appendix: Thermodynamics of Membrane Transport

    2. Physiological Structure and Function of Proteins

    3. Structural Organization and Properties of Appendix: Exponential Time Course Membrane Lipids

    4. Cell Membranes and Model Membranes

    5. Lipid Domains and Biological Membrane Function

    6. Ultrastructure of Cells

    7. Energy Production and Metabolism

    8. Physiology of Mitochondria

    9. Signal Transduction

    10. Calcium as an Intracellular Second Messenger: Mediation by Calcium-Binding Proteins

    11. Regulation of Cellular Functions by Extracellular Calcium

    12. Cellular Responses to Hormones

    Section II Membrane Potential, Transport Physiology, Pumps, and Exchangers

    13. Diffusion and Permeability

    Appendix: Exponential Time Course of Diffusion

    14. Origin of Resting Membrane Potentials


    15. Gibbs-Donnan Equilibrium Potentials

    16. Mechanisms of Carrier-Mediated Transport: Facilitated Diffusion, Cotransport, and Countertransport

    17. Sodium Pump Function

    18. Ca2 +-ATPases

    19. Na+-Ca2+ Exchange Currents

    20. Intracellular Chloride Regulation

    21. Osmosis and Regulation of Cell Volume

    22. Intracellular pH Regulation

    23. Membrane Transport in Red Blood Cells

    Section III Membrane Excitability and Ion Channels

    24. Cable Properties and Propagation of Action Potentials

    Appendix 1: Propagation in Cardiac Muscle and Smooth Muscles

    Appendix 2: Derivation of the Cable Equation and the AC Length Constant

    25. Electrogenesis of Membrane Excitability

    26. Patch-Clamp Techniques and Analysis

    27. Structure and Mechanism of Voltage-Gated Ion Channels

    28. Biology of Neurons

    29. Ion Channels in Nonexcitable Cells

    30. Ion Channels in Sperm

    31. Biology of Gap Junctions

    32. Biophysics of the Nuclear Envelope

    33. Regulation of Ion Channels by Phosphorylation

    34. Direct Regulation of Ion Channels by G Proteins

    35. Developmental Changes in Ion Channels

    36. Regulation of Ion Channels by Membrane Proteins and Cytoskeleton

    Section IV Ion Channels as Targets for Toxins, Drugs, and Genetic Diseases

    37. Ion Channels as Targets for Toxins

    38. Ion Channels as Targets for Drugs

    39. Ion Channels as Targets for Disease

    Section V Synaptic Transmission and Sensory Transduction

    40. Ligand-Gated Ion Channels

    41. Synaptic Transmission

    42. Excitation-Secretion Coupling

    43. Stimulus-Response Coupling in Metabolic Sensor Cells

    44. Mechanosensitive Ion Channels in Eukaryotic Cells

    45. Sensory Receptors and Mechanotransduction

    46. Acoustic Transduction

    Appendix: Self-Referencing Electrodes for the Measurement of Extracellular Potential and Chemical Gradients

    47. Cyclic Nucleotide-Gated Ion Channels

    48. Visual Transduction

    49. Gustatory and Olfactory Sensory Transduction

    50. Electroreceptors and Magnetoreceptors

    Appendix: The Biophysics of Electroreception in Ampullary Organs of Elasmobranch Fishes

    Section VI Muscle and Other Contractile Systems

    51. Skeletal Muscle Action Potentials

    52. Cardiac Action Potentials

    53. Smooth Muscle Action Potentials and Electrical Profiles

    54. Excitation-Contraction Coupling in Skeletal Muscle

    55. Ca2+ Release from Sarcoplasmic Reticulum in Muscle

    56. Contraction of Muscles

    57. Amoeboid Movement, Cilia, and Flagella

    58. Centrin-Based Contraction and Bacterial Flagella

    59. Effects of High Pressure on Cellular Processes

    60. Electrocytes of Electric Fish

    Section VII Protozoa and Bacteria

    61. Physiological Adaptations of Protists

    61. Physiology of Prokaryotic Cells

    Section VIII Plant Cells, Photosynthesis, and Bioluminescence

    63. Plant Cell Physiology

    64. Photosynthesis

    65. Bioluminescence

    Section IX Cell Division and Programmed Cell Death

    66. Regulation of Cell Division in Higher Eukaryotes

    67. Cancer Cell Properties

    68. Apoptosis

    69. Effects of Ionizing Radiation on Cells


    70. Review of Electricity and Cable Properties


Product details

  • No. of pages: 1235
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: August 2, 2001
  • Imprint: Academic Press
  • eBook ISBN: 9780080574554

About the Editor

Nicholas Sperelakis

Professor Sperelakis currently is Professor and Chairman Emeritus of Physiology and Biophysics at the College of Medicine at the University of Cincinnati. He is a cell physiologist specializing in cellular electrophysiology. Dr Sperelakis received a B.S. in Chemistry, M.S. in Physiology in 1955, and a Ph.D. in Physiology in 1957, all from the University of Illinois, Urbana. He was also trained in electronics, receiving a certificate from the U.S. Navy & Marine Corps Electronics School in Treasure Island, San Francisco. He served in the U.S. Marine Corps during the Korean War. Dr. Sperelakis is the author/co-author of over 550 scientific articles in journals and books. He has lectured at numerous universities worldwide and at international conferences/symposia. He has also trained many postdoctoral fellows and graduate students, and has been a visiting professor at several foreign universities. Professor Sperelakis has served on a number of journal editorial boards. He is a member of numerous professional societies and has served on the Council for several of them. He has served on the science program advisory committees for various international conferences and has organized several conferences. Dr. Sperelakis was an Established Investigator of the American Heart Association (AHA), Fellow at the Marine Biological Laboratory (Woods Hole), and elected Fellow of the American College of Cardiology (FACC). He received Awards for research excellence from Ohio AHA in 1995 and SW Ohio in 1996. His listings include Who's Who in the World, in America, in Science and Engineering, in Medicine and Healthcare, and in American Education.

Affiliations and Expertise

University of Cincinnati, Ohio, U.S.A.

Ratings and Reviews

Write a review

There are currently no reviews for "Cell Physiology Source Book"