Cell-Derived Matrices Part B

Cell-Derived Matrices Part B

1st Edition - April 23, 2020

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  • Editors: David Caballero, Subhas Kundu, Rui Reis
  • Hardcover ISBN: 9780128201749
  • eBook ISBN: 9780128201756

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Cell-Derived Matrices Part B, Volume 157 provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Chapters in this new release include Glaucomatous cell-derived matrices, Cardiac tissue explants decellularization, Decellularization of skin matrices for wound healing applications, Guiding axonal growth by aligned cell-derived matrices for spinal cord injury regeneration, Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration, Amniotic decellularized matrices, Three-Dimensional (3-D) Tissue Reconstruction without Scaffold, Tubular cell-derived matrices for TERM applications, and more.

Key Features

  • Contains contributions from leading experts in the field from across the globe
  • Covers a wide array of topics surrounding the use of cell-derived matrices for tissue engineering and regenerative medicine applications
  • Includes relevant, analysis-based topics, such as the quantification of mechanical properties, decellularization protocols, and innovative matrix engineering methods


Postgraduates and researchers in the area of tissue engineering, biophysics and cellular biology, and other related scientific areas

Table of Contents

  • Preface
    David Caballero, Subhas C. Kundu and Rui L. Reis

    Section 1: Tissue decellularization and characterization methods
    1. Decellularization of porcine heart tissue to obtain extracellular matrix based hydrogels
    Rabeil Sakina, Aida Llucià-Valldeperas, Ana Henriques Lourenço, Abhishek Harichandan, Sandro Gelsomino, Paul Wieringa, Carlos Mota and Lorenzo Moroni
    2. Method to decellularize the human chorion membrane
    Laura P. Frazão, Joana Vieira-de-Castro, Cristina Nogueira-Silva and Nuno M. Neves
    3. Protocols for decellularization of human amniotic membrane
    Sadjad Khosravimelal, Maryam Momeni, Mahdieh Gholipur, Subhas C. Kundu and Mazaher Gholipourmalekabadi
    4. Use of supercritical CO2 in soft tissue decellularization
    Bengisu Topuz, Gülçin Günal, Selcan Guler and Halil Murat Aydin
    5. Corneal extracellular matrix decellularization
    Mark Ahearne

    Section 2: Decellularized tissues for tissue engineering and disease modelling
    6. Implementation of a basement membrane invasion assay using mesenteric tissue
    Ritobrata Ghose, Alistair J. Rice, Ernesto Cortes, Upamanyu Ghose, Dariusz Lachowski and Armando del Rio Hernandez
    7. Decellularized human bone as a 3D model to study skeletal progenitor cells in a natural environment
    Ana Rita Pereira, Maximilian Rudert and Marietta Herrmann
    8. Cell sheet tissue engineering for scaffold-free three-dimensional (3D) tissue reconstruction
    Kyungsook Kim, Sophia Bou-Ghannam and Teruo Okano
    9. Decellularized matrices for tumor cell modeling
    Virginia Brancato, Maurizio Ventre, Rui L. Reis and Paolo Antonio Netti
    10. Tissue-derived decellularized extracellular matrices toward cartilage repair and regeneration
    Piyali Das, Yogendra Pratap Singh, Biman B. Mandal and Samit Kumar Nandi

    Section 3: Hybrid systems
    11.The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture
    Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon and Dimitrios I. Zeugolis

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: April 23, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128201749
  • eBook ISBN: 9780128201756

About the Serial Volume Editors

David Caballero

Dr. David Caballero is a senior Research Associate at the 3B’s Research Group, I3Bs – Institute for Biomaterials, Biodegradables and Biomimetics at University of Minho (Portugal). Dr. Caballero has broad experience in the fields of biophysics, bioengineering, microfluidics, and nanotechnology. His main research interests include the development of novel bioengineered in vitro models to study the mechanistic determinants of cancer cell invasion. Currently, Dr. Caballero work focuses in the development of innovative multi-organ-on-chip tumor models using engineered native-like 3D biomaterials for drug screening applications.

Affiliations and Expertise

Senior Research Associate, 3B’s Research Group, I3Bs – Institute for Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal

Subhas Kundu

Subhas C. Kundu, PhD, is a Research Coordinator and former European Research Area Chair at the 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of the University of Minho, Portugal. He was a former Full Professor and founder Head of the Department of Biotechnology at the Indian Institute of Technology Kharagpur, India. His research interests include natural-based biomaterials matrices, particularly silk, for biomedical applications, including 3D in vitro cancer models for investigating tumour growth and progression.

Affiliations and Expertise

Research Coordinator and former European Research Area Chair, 3B´s Research Group, I3Bs, Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal.

Rui Reis

Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.

Affiliations and Expertise

President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal

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