Cell Biology

Cell Biology

First published on October 3, 2016

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  • Authors: Thomas Pollard, William Earnshaw, Jennifer Lippincott-Schwartz, Graham Johnson
  • eBook ISBN: 9780323400022
  • Hardcover ISBN: 9780323341264

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Description

The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today’s students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time.

Key Features

  • Clearly written format incorporates rich illustrations, diagrams, and charts.
  • Uses real examples to illustrate key cell biology concepts.
  • Includes beneficial cell physiology coverage.
  • Clinically oriented text relates cell biology to pathophysiology and medicine.
  • Takes a mechanistic approach to molecular processes.

Table of Contents

  • Section 1: Introduction to Cell Biology

    1 Introduction to Cells

    2 Evolution of Life on Earth

    Section 2: Chemical and Physical Background

    3 Molecules: Structures and Dynamics

    4 Biophysical Principles

    5 Macromolecular Assembly

    6 Research Strategies

    Section 3: Chromatin, Chromosomes, and the Cell Nucleus

    7 Chromosome Organization

    8 DNA Packaging in Chromatin and Chromosomes

    9 Nuclear Structure and Dynamics

    Section 4: Central Dogma: From Gene to Protein

    10 Gene Expression

    11 Eukaryotic RNA Processing

    12 Protein Synthesis and Folding

    Section 5: Membrane Structure and Function

    13 Membrane Structure and Dynamics

    14 Membrane Pumps

    15  Membrane Carriers

    16 Membrane Channels

    17 Membrane Physiology

    Section 6: Cellular Organelles and Membrane Trafficking

    18 Posttranslational Targeting of Proteins

    19 Mitochondria, Chloroplasts, Peroxisomes

    20 Endoplasmic Reticulum

    21 Secretory Membrane System and Golgi Apparatus

    22 Endocytosis and the Endosomal Membrane

    23 Processing and Degradation of Cellular Components

    Section 7: Signaling Mechanisms

    24 Plasma Membrane Receptors

    25 Protein Hardware for Signaling

    26 Second Messengers

    27 Integration of Signals

    Section 8: Cellular Adhesion and the Extracellular Matrix

    28 Cells of the Extracellular Matrix and Immune System

    29 Extracellular Matrix Molecules

    30 Cellular Adhesion

    31 Intercellular Junctions

    32 Connective Tissues

    Section 9: Cytoskeleton and Cellular Motility

    33 Actin and Actin-Binding Proteins

    34 Microtubules and Centrosomes

    35 Intermediate Filaments

    36 Motor Proteins

    37 Intracellular Motility

    38 Cellular Motility

    39 Muscles

    Section 10: Cell Cycle

    40 Introduction to the Cell Cycle

    41 G1 Phase and Regulation of Cell Proliferation

    42 S Phase and DNA Replication

    43 G2 Phase and Control of Entry into Mitosis

    44 Mitosis and Cytokinesis

    45 Meiosis

    46 Programmed Cell Death

    Glossary

    Appendix

Product details

  • No. of pages: 908
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: October 3, 2016
  • Imprint: Elsevier
  • eBook ISBN: 9780323400022
  • Hardcover ISBN: 9780323341264

About the Authors

Thomas Pollard

Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society

Affiliations and Expertise

Sterling Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT

William Earnshaw

William Charles Earnshaw is Professor of Chromosome Dynamics at the University of Edinburgh where he has been a Wellcome Trust Principal Research Fellow since 1996. Earnshaw is an elected Fellow of the Royal Society since 2013 for his studies of mitotic chromosome structure and segregation. Before Edinburgh, he was Professor of Cell Biology and Anatomy at Johns Hopkins School of Medicine.

Affiliations and Expertise

Professor and Wellcome Trust Principal Research Fellow, Wellcome Trust Centre for Cell Biology, ICB, University of Edinburgh, Scotland, United Kingdom

Jennifer Lippincott-Schwartz

Jennifer Lippincott-Swartz is Group Leader at the Howard Hughes Medical Institute Janelia Research Campus. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Before Janelia, Lippincott-Swartz was a primary investigator and chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Her work there included a collaboration with physicists Eric Betzig and Harald Hess (now group leaders at Janelia), who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the 2014 Nobel Prize in Chemistry.

Affiliations and Expertise

Group Leader, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, United States

Graham Johnson

Graham Johnson is a computational biologist and Certified Medical Illustrator (CMI) with approx. 20 years of professional experience. He is Director of the Animated Cell at the Allen Institute. Before the Allen Institute, Johnson’s lab in the California Institute for Quantitative Biosciences at the University of California, San Francisco worked to generate, simulate and visualize molecular models of cells. His lab’s Mesoscope project and his team at Allen Institute continue this mission by uniting biologists, programmers and artists to interoperate the computational tools of science and art.

Affiliations and Expertise

Director, Animated Cell, Allen Institute for Cell Biology, Seattle, Washington;, QB3 Faculty Fellow, University of California, San Francisco, San Francisco, California

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