Cell Biology and Immunology of Leukocyte Function - 1st Edition - ISBN: 9780125696500, 9780323141864

Cell Biology and Immunology of Leukocyte Function

1st Edition

Authors: Efraim Racker
eBook ISBN: 9780323141864
Imprint: Academic Press
Published Date: 1st January 1979
Page Count: 990
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Cell Biology and Immunology of Leukocyte Function is a collection of papers presented at the 12th International Leukocyte Culture Conference, held in Beersheba, Israel on June 1978. This book is organized into seven parts encompassing 111 chapters. The contributors cover the different aspects of cell biology and immunology and the unique leukocyte function. Part I describes the mechanism of lymphocyte activation, the structure and function of the plasma membrane, and the macromolecular synthesis during lymphocyte activation. This part also deals with the interaction of lymphocytes with mitogenic lectins, the comparison of the mitogenic and nonmitogenic lectin binding, and the role of macrophages in the response of lymphocytes to lectins. Part II explores the thymic factors and the development of characteristic markers, antigens, and receptors. This part particularly emphasizes lymphocyte differentiation. Parts III and IV examine the genetic control and intercellular interactions involved in leukocyte function and the parameters of the immune response under in vitro conditions. Chapters on cytotoxicity, the mechanisms of phagocytic killing, autoimmunity, and the responses of leukocytes to tumor cells are included in these parts. Part V discusses the interactions of viruses and leukocytes and provides data on the physical mapping and analysis of sarcoma and leukemia viruses, while Part VI considers the application of leukocyte culture to problems of clinical medicine. Part VII involves the study of radiation effects, with an emphasis on the application of total lymphoid irradiation to the induction of transplantation tolerance. This part also looks into the role of the DNA repair process. Cell biologists, immunologists, and biomedical scientists and researchers will greatly benefit from this book.

Table of Contents




Chapter I Lymphocyte Activation

Section 1 Plasma Membrane Structure and Function

The Lymphocyte Membrane and the Cytoskeleton

Triggering Signals for T-Cell Activation

Studies of Lymphocyte Activation

Functional Organization of the Lymphocyte Plasma Membrane Relating to Cell Activation

Investigations on the Role of Ca2+ as a Potential Second Messenger for T and B Lymphocyte Activation and Its Relevance in DNA Synthesis

A Model for the Control of Potassium Transport in PHA-Stimulated Human Blood Lymphocytes

Effect of Con A on the Cation Affinity of the Na+-K+- Pump in Lymphocytes

Activation of Lymphocytes without Mitogen by Increasing the Calcium Content in the Cell Culture Medium

Workshop Report: Membrane Mechanisms in Lymphocyte Activation

Section 2 Macromolecular Synthesis

Synthesis and Processing of RNA in Stimulated Fibroblasts and Lymphocytes

Regulation of Protein Synthesis during Lymphocyte Activation by Phytohaemagglutinin

Evidence for and against Unusual Species of DNA in Lymphocyte Activation

Studies on mRNA in Resting and Growing Lymphocytes

V- and C-Parts of Immunoglobulin a-Chain Genes Are Separate in Myeloma

Evidence of a Nonmessenger RNA which Is Rate Limiting for Protein Synthesis in Resting Lymphocytes

Adenylate Cyclase in Normal and Leukemic Human

Section 3 Action of Mitogens

On the Commitment of Lymphocytes to DNA Replication: A Possible Role for Transglutaminase

Cooperation Requirements of Mitogen-Stimulated Lymphocytes in Agarose- Gel Cultures

Lectin-Binding Surface Proteins of Human T-Lymphocytes: A Comparison between Mitogenic and Nonmitogenic Lectins

Parallel Induction of T-Cell Stimulation: Positive Control of T-Cell Response by Mitogen-Tested Macrophages

Chapter II Lymphocyte Differentiation

Section 1 Thymic Factors

Biological Activities and Site of Action of the Circulating Thymic Factor

Recent Developments in the Classification and Bioassay of Thymosin Polypeptides

Correlation between the Cellular Levels of cAMP Cell-Mediated Immunocompetence and the Thymic Humoral Factor (THF)

Immunoregulation by Thymopoietin and Bursopoietin (Abstract)

In Vitro Effect of Thymic Epithelial Culture Supernatant (TES) on T-Cell Markers and Functions

T-Thymus-Dependent Human Serum Factor Active on Precursors of Mature T Cells

Delineation of Separate Populations of Precursor T and B Cells in the Avian Embryo

Induction of B- and T-Cell Differentiation by Chicken Bursa and Thymus Reticular Epithelial Cells

The Role of Prothymocytes and the Thymic Microenvironment in the Pathogenesis of Thymic Lymphomas

Workshop Report: Thymic Hormones

Section 2 Surface Antigen Receptors and Markers

The Differences in Structure between Secreted and Cell Surface Membrane Immunoglobulins

Isolation and Chemical Characterization of the Active Site of A Lymphocyte Fc Receptor

Membrane Locking and the Tolerant B Cell

Biological Function and Migratory Behavior of T-Lymphocytes Mediating Delayed Type Hypersensitivity Depend on the Oxidation/Reduction State of Membrane Carbohydrates

Is Serological Polymorphism of Human DR Antigens Determined by Structural Differences in the Small (B) Chain?

Reduced Binding of Ouabain by Chronic Lymphocytic Leukemia Lymphocytes

Heterogeneity of T-Cell Surface Markers and Terminal Transferase of AKR Lymphomas: A Clue to Functional Heterogeneity

Workshop Report: Leukocyte Markers and Receptors

Chapter III Genetic Control and Intercellular Interactions

Section 1 Genetics

Alloactivation of T Lymphocytes: Alternative Pathways

Why Associative Recognition?

Role of the Light Chain in Studies of Linkage of Genes Controlling Idiotype and Heavy Chain Allotype

A Molecular Interaction Model for Ir Gene Complementation

I-Region Control of the Activity of Allogeneic Effect Factor

Section 2 Intercellular Cooperation

The Influence of Macrophage IR Gene Function on T and B Lymphocyte

The Interaction between Initiator and Recruited T-Lymphocytes

Cell-Mediated Cytotoxicity to Trinitrophenyl-Modified Autologous Cells in Mice and Men

Ia Antigens on Suppressor, Amplifier, and Helper T Cells

The Role of the I-Region in the Control of Macrophage T Cell and T Cell-B Cell Interaction

The Monogamous T Helper Cell

Human B-Cell Activation In Vitro: Antigen-Specific Helper and Suppressor Effects Are Mediated by Distinct T-Cell Subpopulations

Differentiation of Helper T Cells Operative in Antibody Synthesis and Cell-Mediated Lympholysis (CML)

Viruses and Alloantigens Can Act as Helper Determinants for Antibody Responses to Another Surface Antigen, THY-1

Workshop Report: Intercellular Cooperation

Section 3 Suppressor Cells

Immune Surveillance and Fetomaternal Relationships: Suppression of Immune Functions by Mouse Amniotic Fluid

Active Cell-Mediated Suppression for Histocompatibility Determinants Produced by T Cells from Normal or Tolerant Mice

Characterization of Suppressive T Cell Fc Receptor, Its Relation with the Major Histocompatibility Complex

Suppressor Cells Regulating the in Vivo Induction of Cytotoxic T Lymphocytes and of Memory Cells for a Secondary in Vitro CMC Response

Multiple Subpopulations of Lymphoid Cells Regulating Human B-Cell Function

Workshop Report: Suppressor Cells

Section 4 Soluble Immunoregulatory Molecules (Lymphokines)

In Vivo Release of Lymphokines

Immunological Role of Macrophage- and Lymphocyte-Derived Amplification Factors

Biochemical Characterization of MIF Maf Macrophage Interactions: A Putative Glycolipid Receptor for MIF, the Existence of Two Distinct MIFs, and Their

Regulation by Macrophage- Associated Esterases

Different Cellular Sources for the Production of Immunue Interferon and Macrophage Migration Inhibitory Factor

Biological Activities of a Macrophage Chemotaxis Inhibitor (MCI) Produced by Neoplasma

Characterization of Radiolabeled Guinea Pig Lymphocyte Activation Products and Their Correlation to Macrophage Migration Inhibitory Activity

Control of Growth and Differentiation in Normal and Malignant Leukocytes: The Protein Regulators MGI and TCI

Cellular Interactions in Generation of Granuloid Colony-Stimulating Factor (CSF) by Lipopolysaccharide (LPS)- Stimulated Lymphoid Cells

Source and Functional Characteristics of the Mitogenic Factor Inducing Continued Proliferation of Human T Cells

Characterization of Immune Interferon Induced in Nude Mice Spleen Cells

T-Cell Hybridomas Secreting Suppressor Factor

Chapter IV Parameters of Immune Reactivity In Vitro

Section 1 Cytotoxicity

HLA-Restricted Killing of Male Targets by Multitransfused Females in the Cell-Mediated Lympholysis Test

T-Cell Mediated Cytolysis: From the Lysis of H-2 Negative Target Cells to the Inductive Effect of Xenogeneic Serum

Polar Events in T-Lymphocyte Mediated Lysis: Unidirectional Killing during Bidirectional Interaction of Cytoxic T Lymphocytes

Transfer of Protein-Labeled Material to Target Cells by Cytotoxic Lymphocytes

Effect of Membrane Lipid Composition on Immune Cell Function

Workshop Report: Cytotoxicity

Section 2 Mechanisms in Phagocyte Killing

Phagocyte-Produced Free Radicals: Roles in Cytotoxicity and Inflammation

The Role of Hydrogen Peroxide in the Cytotoxicity of Neutrophils to Trypanosoma dionissi

A Comparative Study of Killing Mechanisms in Guinea Pig Alveolar Macrophages and Polymorphonuclear Leukocytes

Stimulation of Polymorphonuclear Leukocyte Bactericidal Activity by Supernatants of Activated Mononuclear Cells and Long-Term Lymphoid Cell Lines

Development and Preliminary Application of Radiometric Assays for Measuring Opsonization, Phagocytosis and Intracellular Killing

Section 3 Autoimmunity

Autoimmunity in Acquired Dysgammaglobulinemia of Chickens

Vx Anti-Parent Cell-Mediated Lympholysis: Autoreactive Effectors and Requirement of Parental T Cells for Stimulation

Suppressor Cell Regulation of Self-Tolerance

Blocking of Sensitization to Encephalitogenic Basic Protein in Vitro by Synthetic Basic Copolymer (COP1)

Cytotoxic Effect of Macrophages from Nyasthenic Animals on Muscle Cells in Culture

Suppressor Cells Directed against Self-Receptors in Experimental Autologous Glomerulonephritis Detected by MIF Assays

Section 4 Leukocytes and Tumor Cells

Tumor-Induced Dualistic Suppressor Cell Regulation: Macrophages and Suppressor T Cells

Opposing Tumorogenic and Immunogenic Properties of the in Vitro and the In Vivo Sublines of Moloney-Induced Tumor

Antigenic Differences Exist between Cell Surface Antigens of the Local Tumor and Its Metastases

Tumor Metastases and Cell-Mediated Immunity in a Model System in DBA/2 Mice. Induction and Specificity of Syngeneic Cytotoxic T Cells

Iriimunosuppressor Cells in the Regulation of the Antitumor Response

The Active T Rosette Test: Its Significance and Its Use

Workshop Summary: Rosetting

Cloning of Human T-Lymphocytes

Workshop Summary: Continuous Culture of Lymphocytes

Idiotype and Lymphocytes

Workshop Summary: Lymphocytes and Idiotypes

Chapter V Viruses and Lymphocytes

Interaction of Viruses with Lymphoid Cells

Biological Effects of an Antiserum Directed against Endogenous Zenotropic C-Type Virus

Cell Surface Antigen Expression on Thymocytes, Thymoblasts, and Thymic Leukemia (GRSL) Cells: Relation to Differentiation and Growth

Genome Organization of Retroviruses Physical Mapping of Murine Sarcoma Virus and Heteroduplex Analysis of Recombinant Murine Leukemia Viruses

Analysis of Requirements for Cell-Mediated Lysis Interaction between Viral Glycoproteins and Cell Plasma Membranes

Workshop Summary: Viruses and Lymphocytes

Chapter VI Leukocyte Culture And Clinical Medicine

B-Cell Differentiation in Multiple Myeloma

Circulating T Cell Subset with a Reversible E-Rosetting Capacity in Breast Cancer and Its Role in Cell-Mediated Immunity

Locomotor Activity of Leukemic Blasts from Patients with Acute Myeloid Leukemia and Its Relationship with Receptors for IgG-Fc

Severe Combined Immunodeficiency Disease: A Disorder of both Immune Function and Blood Coagulation

Defective T Cell-Macrophage Interaction in Leprosy

Restoration of Neutrophil Chemotactic Responsiveness by Levamisole Treatment in Patients with the Hyper-IgE Syndrome

Chapter VII Radiation Effects And Leukocyte Malignancy

The Response of the Immune System to Ionizing Radiation Points to Radiosensitive Cellular Processes Other than Division

Immunosuppression and Permanent Transplantation Tolerance across Major Histocompatibility Barriers Following Total Lymphoid Irradiation

Problems Involving DNA Repair in Lymphocytes as Biological Dosimeters

Author Index

Subject Index


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Efraim Racker

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