Cell Biology A Comprehensive Treatise V4

Cell Biology A Comprehensive Treatise V4

Gene Expression: Translation and the Behavior of Proteins

1st Edition - August 28, 1980

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  • Editor: David Prescott
  • eBook ISBN: 9780323147620

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Cell Biology, A Comprehensive Treatise, Volume 4: Gene Expression: Translation and the Behavior of Proteins discusses the translation of genetic information into proteins. It also explains the activities and behaviors of proteins, which is the final stage of gene expression. This book opens with a discussion of the components and mechanism of the translational machinery – their structures, biogenesis, and cellular levels. It then explains the protein synthesis, wherein each chapter focuses on one aspect of the detailed process. Other topics covered in this book are the structure and function of cytoplasmic ribonucleoprotein complexes and the proteolytic cleavage in the posttranslational processing of proteins. This text also covers the regulation of enzyme activity and the movement of material between nucleus and cytoplasm. The last three chapters are more in-depth discussions on protein synthesis, intracellular transport, regulation, and secretion. As with the other volumes of this book series, readers will definitely benefit from the vast information provided in this book regarding protein, its activities, behaviors, and synthesis.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    1 The Translational Machinery: Components and Mechanism

    I. Introduction

    II. Macromolecular Components

    III. Biosynthesis of Translational Components

    IV. Pathway and Mechanism

    V. Perspectives


    2 Regulation of Eukaryotic Protein Synthesis

    I. Introduction

    II. Regulation at the Step of Met-tRNAf Binding to 40 S Ribosomal Subunits

    III. Regulation at the Step of mRNA Binding to the Ribosomal Initiation Complex

    IV. Factors with Receptor Sites on the Cell Membrane

    V. Conclusion


    3 Masked Messenger RNA and the Regulation of Protein Synthesis in Eggs and Embryos

    I. Introduction

    II. Maternal Effects and the Existence of Stored mRNA in Eggs

    III. Protein Synthesis Following Fertilization of Sea Urchin Eggs

    IV. Masking and the Control of Protein Synthesis in Eggs and Embryos

    V. Concluding Remarks


    4 Structure and Function of Nuclear and Cytoplasmic Ribonucleoprotein Complexes

    I. Introduction

    II. Nuclear RNP

    III. Cytoplasmic RNP Containing mRNA


    5 Proteolytic Cleavage in the Posttranslational Processing of Proteins

    I. Introduction

    II. Early Cleavages—The Presecretory Proteins

    III. Posttranslational Cleavages—Intracellular (The Proproteins)


    6 Principles of the Regulation of Enzyme Activity

    I. Introduction

    II. Some Basic Concepts of Biochemical Regulation

    III. Mechanisms of Controlling Enzyme Activity

    IV. Integration of Metabolic Controls

    V. Conclusion


    7 The Movement of Material between Nucleus and Cytoplasm

    I. Introduction

    II. Determinants of Nucleocytoplasmic Movements

    III. Thermodynamic Equilibrium

    IV. Kinetics

    V. Nucleocytoplasmic Interrelations


    8 Regulation of Location of Intracellular Proteins

    I. Introduction and Overview

    II. General Mechanisms

    III. Role of Membranes: Protein-Membrane Interactions

    IV. Organelle Biogenesis and Localization Pathways

    V. Reconstitution Systems

    VI. Genetic Systems

    VII. Summary


    9 The Biogenesis of Supramolecular Structures

    I. Introduction

    II. Molecular Interactions during Assembly

    III. The Assembly Reactions

    IV. Conclusion


    10 Protein Secretion and Transport

    I. Introduction

    II. General Morphology of Secretory Cells

    III. Methodology

    IV. Synthesis and Segregation of Secondary Proteins

    V. Intracellular Protein Migration

    VI. Storage and Discharge

    VII. Processing of Secretory Proteins during Intracellular Transport

    VIII. Membrane Redistribution during Secretion

    IX. Variations in the Secretory Pathway of Different Types of Cells

    X. Concluding Remarks



Product details

  • No. of pages: 510
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: August 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323147620

About the Editor

David Prescott

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