Cell Biology, A Comprehensive Treatise, Volume 4: Gene Expression: Translation and the Behavior of Proteins discusses the translation of genetic information into proteins. It also explains the activities and behaviors of proteins, which is the final stage of gene expression. This book opens with a discussion of the components and mechanism of the translational machinery – their structures, biogenesis, and cellular levels. It then explains the protein synthesis, wherein each chapter focuses on one aspect of the detailed process. Other topics covered in this book are the structure and function of cytoplasmic ribonucleoprotein complexes and the proteolytic cleavage in the posttranslational processing of proteins. This text also covers the regulation of enzyme activity and the movement of material between nucleus and cytoplasm. The last three chapters are more in-depth discussions on protein synthesis, intracellular transport, regulation, and secretion. As with the other volumes of this book series, readers will definitely benefit from the vast information provided in this book regarding protein, its activities, behaviors, and synthesis.
List of Contributors Preface Contents of Other Volumes 1 The Translational Machinery: Components and Mechanism I. Introduction II. Macromolecular Components III. Biosynthesis of Translational Components IV. Pathway and Mechanism V. Perspectives References 2 Regulation of Eukaryotic Protein Synthesis I. Introduction II. Regulation at the Step of Met-tRNAf Binding to 40 S Ribosomal Subunits III. Regulation at the Step of mRNA Binding to the Ribosomal Initiation Complex IV. Factors with Receptor Sites on the Cell Membrane V. Conclusion References 3 Masked Messenger RNA and the Regulation of Protein Synthesis in Eggs and Embryos I. Introduction II. Maternal Effects and the Existence of Stored mRNA in Eggs III. Protein Synthesis Following Fertilization of Sea Urchin Eggs IV. Masking and the Control of Protein Synthesis in Eggs and Embryos V. Concluding Remarks References 4 Structure and Function of Nuclear and Cytoplasmic Ribonucleoprotein Complexes I. Introduction II. Nuclear RNP III. Cytoplasmic RNP Containing mRNA References 5 Proteolytic Cleavage in the Posttranslational Processing of Proteins I. Introduction II. Early Cleavages—The Presecretory Proteins III. Posttranslational Cleavages—Intracellular (The Proproteins) References 6 Principles of the Regulation of Enzyme Activity I. Introduction II. Some Basic Concepts of Biochemical Regulation III. Mechanisms of Controlling Enzyme Activity IV. Integration of Metabolic Controls V. Conclusion References 7 The Movement of Material between Nucleus and Cytoplasm I. Introduction II. Determinants of Nucleocytoplasmic Movements III. Thermodynamic Equilibrium IV. Kinetics V. Nucleocytoplasmic Interrelations References 8 Regulation of Location of Intracellul
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- © Academic Press 1980
- 28th August 1980
- Academic Press
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DEPARTMENT OF MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY UNIVERSITY OF COLORADO BOULDER, COLORADO